CD56

TAIPEI, Dec. 4, 2023 /PRNewswire/ -- Supercell Biotechnology Corporation commemorates the first anniversary of rebranding from previously-called SinoCell Technologies, due to the company's capital increase by RMT Holding Group. Demonstrating the strategic move at the Healthcare+ Expo Taiwan, their theme "Hope Begins from Now", encapsulates their global expansion and transformation in healthcare. Supercell, through partnerships in regenerative medicine, has secured an exclusive license for a Japanese-developed natural killer (NK) cell culture technique. The technique, pivotal in cancer cell elimination and immune system enhancement, will be showcased at the expo, highlighting their latest experimental advancements[1]. The majority of NK cells administered on day 14 are CD56brightCD16 -NK cells, which primarily enhance immune function but show reduced expression of the CD16 membrane protein, crucial for tumor cell destruction. Dr. Hiroshi Terunuma's methodology indicates that by day 21, CD56brightCD16 +NK cells become the dominant cell type. These cells demonstrate increased expression of both CD56 and CD16 membrane proteins, enabling both cytotoxic and immunomodulatory effects. The results showed both qualitative and quantitative enhancements, as evidenced by the presence of more than 60 x 108 NK cells, a purity level greater than 80%, and an amplification rate exceeding 1,500-fold. Dr. Hiroshi Terunuma, a distinguished international authority in cancer treatment based in Japan and a long-standing partner of Supercell, has successfully administered NK cell therapy in over 40,000 cases. In a clinical study, 63 patients diagnosed with terminal malignant pancreatic cancer received conventional cancer therapy supplemented by NK cell infusion. Results showed a significant improvement in survival rates, with 41 patients doubling their expected lifespan from 6 to 13 months[2]. Moreover, a British patient with terminal colon cancer achieved a complete remission, showcasing the effectiveness and progressive potential of NK cell therapy.[3] If adopted as a standard practice in future healthcare, this approach could enhance cellular immunity, potentially leading to increased resilience in the face of a progressively complex disease environment. Sean Ishihara, Chairman of RMT Group, parent company of Supercell Biotechnology Corporation, emphasizes, "medical care is a universal right." Unlike typical biotech companies focused on going public, Supercell prioritizes researching and developing safe, effective biotech applications. The company actively collaborates with international experts to realize this mission. Through these partnerships, Supercell aims to deliver top-quality solutions worldwide. SOURCE SUPERCELL BIOTECHNOLOGY CORPORATION

Japanese Ministry of Health, Labor and Welfare grants Orphan Drug Designation to tagraxofusp for blastic plasmacytoid dendritic cell neoplasm (BPDCN) FLORENCE, Italy & NEW YORK--(BUSINESS WIRE)-- The Menarini Group (“Menarini”), a leading international pharmaceutical and diagnostics company, and Stemline Therapeutics, Inc. (“Stemline”), a wholly-owned subsidiary of the Menarini Group, today announced that Nippon Shinyaku Co., Ltd. (Nippon Shinyaku), Stemline’s development partner in Japan, received Orphan Drug Designation for tagraxofusp, from the Japanese Ministry of Health, Labor and Welfare (MHLW) for the expected indication of blastic plasmacytoid dendritic cell neoplasm (BPDCN). This press release features multimedia. View the full release here: BPDCN is an aggressive orphan hematologic malignancy with historically poor clinical outcomes. Stemline’s ELZONRIS® (tagraxofusp) is the only approved treatment for patients with BPDCN, and the first and only approved CD123-targeted therapy, in both the United States and Europe. Orphan drugs are designated by Japan’s MHLW for treatments that are intended for use in fewer than 50,000 patients, where there is also a particularly high medical need. Orphan drug designation can potentially shorten the period required to obtain regulatory approval in Japan by several months, thereby enabling faster patient access. In Japan, tagraxofusp is being developed by Nippon Shinyaku, which is currently conducting a Phase 1/2 clinical trial. In March 2021, Stemline and Nippon Shinyaku entered into an exclusive licensing agreement for the development and commercialization of tagraxofusp in Japan, including the possibility of co-promotion. “The MHLW’s decision to grant Orphan Drug Designation recognizes the potential positive impact tagraxofusp could have on BPDCN patients in Japan, a patient population that currently has limited treatment options,” said Elcin Barker Ergun, CEO of the Menarini Group. “This achievement by our partner, Nippon Shinyaku, advances our commitment to bring transformative new therapeutic options to patients with difficult-to-treat cancers, and to deliver innovative medicines to people around the globe.” About BPDCN BPDCN, formerly blastic NK-cell lymphoma, is an aggressive hematologic malignancy, often with cutaneous manifestations, with historically poor outcomes. BPDCN typically presents in the bone marrow and/or skin and may also involve lymph nodes and viscera. The BPDCN cell of origin is the plasmacytoid dendritic cell (pDC) precursor. The diagnosis of BPDCN is based on the immunophenotypic diagnostic triad of CD123, CD4, and CD56, as well as other markers. The World Health Organization (WHO) termed this disease “BPDCN” in 2008; previous names included blastic NK cell lymphoma and agranular CD4+/CD56+ hematodermic neoplasm. For more information, please visit the BPDCN disease awareness website at . About The Menarini Group The Menarini Group is a leading international pharmaceutical and diagnostics company, with a turnover of over $4.4 billion and over 17,000 employees. Menarini is focused on therapeutic areas with high unmet needs with products for cardiology, oncology, pneumology, gastroenterology, infectious diseases, diabetology, inflammation, and analgesia. With 18 production sites and 9 Research and Development centers, Menarini’s products are available in 140 countries worldwide. For further information, please visit . About Stemline Therapeutics Inc. Stemline Therapeutics, Inc. (“Stemline”) a wholly-owned subsidiary of the Menarini Group, is a commercial-stage biopharmaceutical company focused on the development and commercialization of novel oncology therapeutics. Stemline commercializes ORSERDU® (elacestrant) in the United States, an oral endocrine therapy indicated for the treatment of postmenopausal women or adult men with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy. Stemline also commercializes ELZONRIS® (tagraxofusp-erzs), a novel targeted treatment directed to CD123 for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN), an aggressive hematologic cancer, in the United States and Europe, which is the only approved treatment for BPDCN in the US and EU to date. Stemline also commercializes NEXPOVIO® in Europe, an XPO1 inhibitor for multiple myeloma. Stemline also has an extensive clinical pipeline of small molecules and biologics in various stages of development for a host of solid and hematologic cancers. About Nippon Shinyaku Our mission is to help people lead healthier and happier lives. Through creating unique medicines that will bring hope to patients and families struggling with illness, we aim to be an organization trusted by the community. Please visit our website ( ) for products or detailed information.

Logomix will offer its genome-editing expertise to HebeCell to develop next-generation designer protoNK cells. Credit: Lightspring / Shutterstock.com. Biotechnology company HebeCell has entered a strategic collaboration with synthetic biology company Logomix to research and develop gene-edited natural killer (NK) cells. The companies will also work on discovering genetic alterations that could produce next-generation designer NK cells. Recommended Reports Reports LOA and PTSR Model - AlloRx Stem Cell therapy GlobalData Reports Cells Expressing Neural Cell Adhesion Molecule 1 (Antigen Recognized By Monoclonal Antibody 5.1H1... GlobalData View all Companies Intelligence PSC Corporation Ltd NK Co Ltd LogoMix Inc HebeCell Corp View all Logomix will offer its genome editing expertise to HebeCell to develop next-generation designer protoNK cells. By merging a pluripotent stem cell (PSC)-based platform with genome-editing expertise, the companies will expand and expedite new development to check for de novo genetic alterations that improve the protoNK cells’ persistence and efficacy against cancers. HebeCell CEO John Lu stated: “We know our protoNK cells are strong cytotoxic cells. Our goal is to make PSC-derived protoNK more efficacious in vivo. “This collaboration expands our efforts to develop unique NK cell therapies, and has the potential to create something new and never seen before in the NK therapeutic field.” Established in 2016, HebeCell focuses on the development of NK cell therapeutics, leveraging its 3D PSC platform. The off-the-shelf ProtoNK cell products treat cancer, viral infections and autoimmune conditions. Logomix CEO Taiki Ishikura stated: “Logomix’s proprietary technology, Geno-Writing, is a genome-writing platform that grants cell therapy developers unprecedented freedom to screen, design and write in large-scale genomic alterations in human cells. “Because our technology allows Mb-scale and scarless modifications, [when] applied to any sequences at either or both alleles it is an ideal tool to create a source of allogeneic cell therapy with desired gene edits.” Cell & Gene Therapy coverage on Pharmaceutical Technology is supported by Cytiva. Editorial content is independently produced and follows the highest standards of journalistic integrity. Topic sponsors are not involved in the creation of editorial content. Free Whitepaper Cell and gene therapies: Pipe dream to pipeline The cell and gene industry is gaining momentum, with a new wave of therapies promising to transform the way doctors treat, and even cure, disease. In this report, Cytiva and GlobalData have collaborated to explore the rise of the cell and gene therapy industries, the current state of the market, present and future opportunities for advancement, and the challenges that lie ahead. By Cytiva Thematic By downloading this case study, you acknowledge that GlobalData may share your information with Cytiva Thematic and that your personal data will be used as described in their Privacy Policy