Ferritin

A dedicated session will highlight new advancements in hemodiafiltration therapy showcasing its potential to improve patient outcomes through enhanced toxin removal in dialysis treatments. Company-wide researchers and clinical experts share insights from large global databases, revealing crucial trends in kidney failure etiology, cardiovascular risks, and treatment modalities across different regions. Nearly 75 abstracts presented across a broad range of cutting-edge research, covering topics from the global impact of dialysis to advancements in kidney care technology, sustainability, and health equity. BAD HOMBURG, Germany, Oct. 21, 2024 /PRNewswire/ -- Fresenius Medical Care (FME), the world's leading provider of products and services for individuals with renal diseases, today announced the presentation of nearly 75 company-affiliated research abstracts at the American Society of Nephrology's (ASN) Kidney Week 2024 taking place October 24-27 in San Diego. "We are pleased to present research that exemplifies our ongoing commitment to advancing kidney care on a global scale," said Frank Maddux, MD, Global Chief Medical Officer at Fresenius Medical Care. "This year's abstracts highlight key innovations in treatment approaches, including high-volume hemodiafiltration, as well as the integration of artificial intelligence. We aim to leverage insights from Fresenius Medical Care's global databases to improve patient outcomes and drive more equitable, sustainable care for people working to live meaningful lives with kidney disease worldwide." Fresenius Medical Care has provided an educational grant to the American Society of Nephrology in support of an educational symposium during Kidney Week, The Role of Hemodiafiltration in the Management of Dialysis-Dependent Chronic Kidney Failure, on October 25, 2024, 12:45 PM PDT - 01:45 PM PDT. In recent years, hemodiafiltration (HDF) has been increasingly recognized for the treatment of patients with kidney failure requiring dialysis. HDF uses enhanced convection in combination with diffusion to improve the removal of large solutes such as beta-2-microglobulin and kappa and lambda light chains. While HDF has been used in Europe widely for many years, beginning in 2025, Fresenius Medical Care will gradually introduce this therapy into its Fresenius Kidney Care dialysis clinics in the United States. In February 2024, Fresenius Medical Care received FDA 510(k) clearance for the company's 5008X Hemodialysis System, an HDF and HighVolumeHDF-capable dialysis machine in the U.S. At the ASN Kidney Week 2024, scientific and medical experts from across Fresenius Medical Care will present research related to many important topics in kidney disease care. Highlights of this year's presentations include: Advancing High-Volume Hemodiafiltration (HVHDF) Mortality Risk on Hemodiafiltration Compared with High-Flux Hemodialysis: Real-World Evidence from a Large Brazilian Cohort: Patients undergoing online hemodiafiltration (HDF) have been associated with better survival compared to those on high-flux hemodialysis (HD). Recently, the use of HDF has grown markedly in Brazil, but there is no robust real-world Brazilian study on the impact of this dialysis modality on patient's outcomes. Hemodiafiltration Is Associated with Lower Hospitalization Rates Compared with Hemodialysis in a Singapore Cohort: Hemodialysis (HD) patients suffer from high rates of hospitalization leading to significant morbidity, mortality, and costs. Hemodiafiltration (HDF) has been shown to improve patient outcomes. Adequate Convective Volume Can Be Achieved in Majority of Multiethnic Asian Patients Receiving Hemodiafiltration in Singapore: High-volume hemodiafiltration (HDF) has been shown to improve patient outcomes. However, there is a very common concern amongst healthcare practitioners about the feasibility of achieving optimal convective volume (CV) in Asian patients. Sustainability and Equity in Kidney Care High Prevalence and Inequities in Unmet Social Risk in Diverse Urban Patients on Hemodialysis: Health-related social risks (SR) are associated with adverse health outcomes amongst patients with kidney disease. We aimed to identify and analyze SR in a diverse population of hemodialysis (HD) patients. Survival Sex Differences among Pediatric and Young Adult Hemodialysis Patients in the Global MONDO Registry: For all age groups, women with ESKD on HD have higher rates of cardiovascular (CV) events compared to men, but their all-cause mortality is reduced. Survival in pediatric and young adult HD patients (pts) from across the globe is understudied. Canadian Wildfires of 2023 and Risk of Mortality and Hospitalization Among ESKD Patients: Climate change driven droughts are increasing frequency and intensity of wildfires, a significant source of air pollution. Smoke plumes from the 2023 Canadian wildfires travelled long distances and negatively impacted air quality across large swaths of eastern US. We investigated the association between exposure to 2023 Canadian wildfire-related air pollutants and risk of mortality and hospitalization among hemodialysis patients in New England, the Mid-Atlantic, and the Midwest U.S. Harnessing the Power of Global Databases to Drive Care Cardiovascular Morbidity Patterns in Patients on Dialysis Globally in Apollo Dial DB: Cardiovascular diseases (CVDs) affect most people with kidney failure but are undefined globally. We aimed to analyze CVD prevalence among dialysis patients treated in 40 countries across six continents, as represented in the first version of a global dialysis database called Apollo Dial DB. Profiles of Home Medication Use in Patients on Dialysis Globally: Global patterns of medication use in dialysis are undefined. This project aims to provide a real-world view of home medication use in dialysis using a global dialysis dataset from 40 countries. The most common prescribed medications administered at home by patients were compared by modality. Changes in Fluid Overload during the First 6 Months of Dialysis among More than 13,000 Patients: Fluid overload (FO) is a recognized risk factor for mortality in dialysis patients; however, less has been reported on factors related to changes in FO. Whole-body bioimpedance spectroscopy (BIS) has been validated for hydration assessment. We used Body Composition Monitor (BCM) data, a whole-body BIS, to evaluate changes in the degree of FO during the first 6 months of hemodialysis (HD) or hemodiafiltration (HDF) and characteristics associated with those changes using Apollo Dial DB. Leveraging Artificial Intelligence (AI), Computational Medicine, and Advanced Analytics for Patient Care Arteriovenous Fistula Failure Prediction Using Single Treatment Information: Predicting the natural course of AVF complications with technical surveillance has been an elusive task. We developed a machine learning algorithm assessing the risk of failure of AVF using information collected by the dialysis machine in a single treatment. Validation of a Cloud-Based Convolutional Neural Network Classifying Arteriovenous Access Aneurysms in a Multicenter Study: Arteriovenous (AV) access aneurysms may become life-threatening, e.g., in the event of ruptures. We developed an artificial intelligence classification application (ACA) that categorizes aneurysms using AV access images. This study prospectively evaluates ACA's classification of AV aneurysms against physicians specializing in access care. Joint Modeling of Longitudinal Ferritin Trajectories and COVID-19 Infections in Native American, Hispanic, and White Patients on Hemodialysis: American Indians/Alaska Natives (AIAN) and Hispanic individuals in the U.S. are overrepresented in the hemodialysis (HD) population and were hardest hit by COVID-19. Early in the pandemic, hyperferritinemia was linked to COVID-19 infections. Joint modeling learns from both longitudinal and time-to-event data for predictive accuracy and dynamic estimation. We investigated the predictive utility of ferritin w/ COVID-19 infection in a cohort of AIAN, Hispanic and White HD patients. For more information about Fresenius Medical Care's presence at ASN Kidney Week 2024, please visit . About Fresenius Medical Care: Fresenius Medical Care is the world's leading provider of products and services for individuals with renal diseases of which around 4.1 million patients worldwide regularly undergo dialysis treatment. Through its network of 3,757 dialysis clinics, Fresenius Medical Care provides dialysis treatments for approx. 311,000 patients around the globe. Fresenius Medical Care is also the leading provider of dialysis products such as dialysis machines or dialyzers. Fresenius Medical Care is listed on the Frankfurt Stock Exchange (FME) and on the New York Stock Exchange (FMS). For more information visit the company's website at . Disclaimer: This release contains forward-looking statements that are subject to various risks and uncertainties. Actual results could differ materially from those described in these forward-looking statements due to various factors, including, but not limited to, changes in business, economic and competitive conditions, legal changes, regulatory approvals, impacts related to the COVID-19 pandemic results of clinical studies, foreign exchange rate fluctuations, uncertainties in litigation or investigative proceedings, and the availability of financing. These and other risks and uncertainties are detailed in Fresenius Medical Care's reports filed with the U.S. Securities and Exchange Commission. Fresenius Medical Care does not undertake any responsibility to update the forward-looking statements in this release. Media contact Kirsten Stratton T +1 781 929 8096 [email protected] Christine Peters T +49 160 60 66 770 [email protected] Contact for analysts and investors Dr. Dominik Heger T +49 6172 609 2601 [email protected] SOURCE Fresenius Medical Care Holdings, Inc. 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THURSDAY, Sept. 26, 2024 -- Four out of five pregnant women will become deficient in an essential nutrient, iron, by their third trimester, a new study finds. The researchers and other experts are now advocating that iron levels be routinely checked during a pregnancy for the safety of a mother and her baby. Right now, guidelines from the United States Preventive Services Taskforce (USPSTF), an influential independent panel of medical experts, and the American College of Obstetricians and Gynecologists (ACOG) do not advocate for regular iron checks. However, the new findings suggest that both groups should “change their approach to diagnosis to screen all pregnant women for iron deficiency, irrespective of the presence or absence of anemia, and recommend supplementation when present for the most frequent nutrient deficiency disorder that we encounter," wrote the authors of an editorial accompanying the new study. The findings were published Sept. 26 in the American Journal of Clinical Nutrition . The new research was led by Dr. Elaine McCarthy , a lecturer in nutrition at the School of Food and Nutritional Sciences at University College Cork, in Ireland. Her team noted that pregnancy brings on a 10-fold surge in uptake of dietary iron to supply the needs of both the fetus and the mom-to-be. A woman's bodily "iron stores" at the beginning of her pregnancy can help supply much of this needed iron, but McCarthy's team note that an estimated 50% of women begin pregnancy with insufficient iron stores. Depleted iron levels can, in the worst-case scenario, lead to anemia, which has long been tied to a heightened risk for postpartum depression, postpartum hemorrhage, preterm birth, low birth weight and small-for-gestational age birth. However, iron levels in pregnancy that are low but do not meet the threshold for anemia can still be hazardous, being linked to later neurodevelopmental issues for offspring. In the United States, there's no set rule to test for iron levels in pregnancy in the absence of anemia. The USPSTF, for example, states that evidence is still "insufficient" to mandate such testing. That's in contrast to guidelines from the International Federation of Gynecology and Obstetrics and European Hematology Society, which both advocate for routine tests in a woman's first trimester, regardless of whether she is anemic or not. Just how prevalent is iron deficiency in pregnancy? To find out, McCarthy's team tracked blood levels of the nutrient in 641 Irish women who were pregnant and had a successful delivery for the first time. Testing was done at 15 weeks, 20 weeks and 33 weeks of pregnancy. “In this high-resource setting,” the researchers found that “iron deficiency defined by a variety of biomarkers and thresholds, was very common during pregnancy, despite the cohort profile as generally healthy.” Deficiencies tended to appear later in pregnancies: While none of these relatively well-off, well-cared-for women were iron-deficient in their first trimester, by their third trimester 80% had insufficient levels of iron. However, "iron-containing supplements [mainly multivitamins] taken pre/early pregnancy were associated with a reduced risk of deficiency throughout pregnancy, including the third trimester," McCarthy and colleagues noted. Supplements typically contained a daily 15-17 milligram (mg) dose of iron. They also noted that iron deficiency blood screening should be based on two markers of iron levels, hemoglobin and ferritin, not just hemoglobin alone. Ferritin is a protein that stores iron. The researchers suggest that a blood level of 60 micrograms per liter or less of ferritin at 15 weeks gestation be the cutoff for signaling the potential for iron deficiency. "This has previously been identified as the inflection point at which fetal iron accretion is compromised, leading to poorer neurocognitive function and earlier onset of postnatal iron deficiency in the offspring," McCarthy's team said. The accompanying journal editorial was co-authored by Dr. Michael Auerbach , a clinical professor of medicine at Georgetown University in Washington, D.C., and Dr. Helain Landy , chair of obstetrics and gynecology at Georgetown. Based on the new findings, they are urging both the USPSTF and ACOG to change guidelines and mandate routine iron deficiency testing -- even in the absence of anemia -- for all pregnant women. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

WEDNESDAY, Sept. 4, 2024 -- Genetic predisposition to high ferritin and serum iron status is associated with a lower risk for developing rheumatoid arthritis (RA), according to a study published online Aug. 29 in Global Medical Genetics . Boyuan Wu, from the School of Global Public Health at New York University in New York City, used genetic data from a large genome-wide association study (GWAS) involving 257,953 individuals to identify single nucleotide polymorphisms associated with iron status. These data were analyzed in conjunction with data on RA from the IEU open GWAS project, composed of 5,427 RA cases and 479,171 controls. The researchers observed a causal association for genetic predisposition to high ferritin and serum iron status with lower odds of RA, with statistically significant odds ratios of 0.997 for each one-unit increase in ferritin and 0.997 for serum iron. In Mendelian randomization analyses, there was no significant causal association seen between total iron-binding capacity or transferrin saturation percentage with the risk for developing RA. "Our findings indicate that the total amount of iron in the body, rather than how it is distributed within tissues, might be more important for RA," the authors write. "This raises the intriguing possibility that iron supplementation could be a preventative strategy, but further research is necessary before making any recommendations."