NIACR1 x HMG-CoA reductase x HCAR3

以辛伐他汀片为对照，评价辛伐他汀烟酸缓释片治疗原发性高脂血症的有效性和安全性

对辛伐他汀烟酸缓释片进行人体药代动力学评价；测定主要成分辛伐他汀、烟酸和代谢物辛伐他汀酸、烟酰胺和烟脲酸的经时血药浓度和尿药浓度，估算其主要药代动力学参数，了解辛伐他汀烟酸缓释片在健康人体内的吸收、分布、消除、代谢规律。

This study is being done to find out if tablets containing extended release (ER) niacin, laropiprant, and simvastatin (ERN/LRPT/SIM) are as effective as tablets containing ER niacin and laropiprant taken with simvastatin tablets (ERN/LRPT + SIM) for lowering high cholesterol and high lipid levels in the blood. The primary hypothesis is that ERN/LRPT/SIM 2 g /20 mg is equivalent to ERN/LRPT 2 g coadministered with simvastatin 20 mg in reducing low-density lipoprotein cholestrol (LDL-C).