Last update 01 Nov 2024

Collagen x ELA2

Last update 01 Nov 2024

Basic Info

Related Targets

CollagenELA2

Drugs associated with Collagen x ELA2

Chondroitin sulfate

Target

Collagen x ELA2

Mechanism

Collagen stimulants [+1]

Active Org.

IBSA Institut Biochimique SA [+1]

Originator Org.

IBSA Institut Biochimique SA

Active Indication

Hyperlipidemias [+1]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date01 Jan 1981

Chondroitin sulfate/Taurine

Target

Collagen x ELA2

Mechanism

Collagen stimulants [+1]

Active Org.-

Originator Org.-

Active Indication

Xerophthalmia

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Glucosamine sulfate/Chondroitin sulfate

Target

Collagen x ELA2

Mechanism

Collagen stimulants [+1]

Active Org.-

Originator Org.-

Active Indication-

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Collagen x ELA2

NCT06547424 / Not yet recruitingPhase 1IIT

A Randomized, Controlled, Double-Blind Phase I Clinical Study of Chondroitin Sulfate Supplementation for Treatment of Necrotizing Enterocolitis

The goal of this phase 1 double blind, randomized controlled trial is to determine the safety of chondroitin sulfate supplementation in the neonates with necrotizing enterocolitis. The main questions the study aims to answer are:
Is chondroitin sulfate safe to administer in the neonatal NEC population, and will it have a beneficial profile in the short term intestinal and long term neurodevelopmental sequelae of NEC? Researchers will compare all cause mortality, progression to surgery, systemic inflammatory markers, and long term neurodevelopmental outcomes in those NEC patients who receive chondroitin sulfate compared to those who receive milk or formula placebo.

Start Date01 Jan 2025

Sponsor / Collaborator

Indiana University

IRCT20170608034390N13 / RecruitingPhase 2/3IIT

Evaluating the efficacy of intra-articular injection of high molecular weight hyaluronic acid and Chondroitin on the knee performance of patients with plateau fracture after surgical fixation

Start Date21 Jun 2024

Sponsor / Collaborator

Shahid Beheshti University of Medical Sciences

100 Clinical Results associated with Collagen x ELA2

100 Translational Medicine associated with Collagen x ELA2

0 Patents (Medical) associated with Collagen x ELA2

Literatures (Medical) associated with Collagen x ELA2

01 Apr 2024·Biomedicine & Pharmacotherapy

Blood gene expression biomarkers of response to anti-TNF drugs in pediatric inflammatory bowel diseases before initiation of treatment

Article

Author: Magallares, Lorena ; Rubbini, Gianluca ; Loverdos, Inés ; Montraveta, Montserrat ; Salcedo, Enrique ; Álvarez, Rebeca ; Zapata-Cobo, Paula ; Dopazo, Ana ; Tolín, Mar ; Navas-López, Victor Manuel ; Torres-Peral, Ricardo ; Pérez-Moneo, Begoña ; Bossacoma, Ferrán ; Sánchez, Cesar ; López-Fernández, Luis A ; Velasco, Marta ; Rodríguez, Alejandro ; Palomino, Laura M ; Vellosillo, Perceval ; Moreno-Álvarez, Ana ; Fobelo, María José ; García-Romero, Ruth ; Clemente, Susana ; Segarra, Oscar ; Fernández-Lorenzo, Ana ; Merino-Bohórquez, Vicente ; Salvador-Martín, Sara ; Sanjurjo-Sáez, María

BACKGROUND/AIMSChanges in gene expression profiles among individuals with inflammatory bowel diseases (IBDs) could potentially influence the responsiveness to anti-TNF treatment. The aim of this study was to identify genes that could serve as predictors of early response to anti-TNF therapies in pediatric IBD patients prior to the initiation of treatment.METHODSWe conducted a prospective, longitudinal, and multicenter study, enrolling 24 pediatric IBD patients aged less than 18 years who were initiating treatment with either infliximab or adalimumab. RNA-seq from blood samples was analyzed using the DESeq2 library by comparing responders and non-responders to anti-TNF drugs.RESULTSBioinformatic analyses unveiled 102 differentially expressed genes, with 99 genes exhibiting higher expression in responders compared to non-responders prior to the initiation of anti-TNF therapy. Functional enrichment analyses highlighted defense response to Gram-negative bacteria (FDR = 2.3 ×10-7) as the most significant biological processes, and hemoglobin binding (FDR = 0.002), as the most significant molecular function. Gene Set Enrichment Analysis (GSEA) revealed notable enrichment in transcriptional misregulation in cancer (FDR = 0.016). Notably, 13 genes (CEACAM8, CEACAM6, CILP2, COL17A1, OLFM4, INHBA, LCN2, LTF, MMP8, DEFA4, PRTN3, AZU1, and ELANE) were selected for validation, and a consistent trend of increased expression in responders prior to drug administration was observed for most of these genes, with findings for 4 of them being statistically significant (CEACAM8, LCN2, LTF2, and PRTN3).CONCLUSIONSWe identified 102 differentially expressed genes involved in the response to anti-TNF drugs in children with IBDs and validated CEACAM8, LCN2, LTF2, and PRTN3. Genes participating in defense response to Gram-negative bacterium, serine-type endopeptidase activity, and transcriptional misregulation in cancer are good candidates for anticipating the response to anti-TNF drugs in children with IBDs.

12 Sep 2023·International journal of molecular sciences

Dynamic Interplay in Tumor Ecosystems: Communication between Hepatoma Cells and Fibroblasts.

Article

Author: Kovalszky, Ilona ; Petővári, Gábor ; Baghy, Kornélia ; Reszegi, Andrea ; Pesti, Adrián ; Füle, Tibor ; Dezső, Katalin ; Tátrai, Péter ; Turiák, Lilla ; Tóth, Gábor ; Kiss, András ; Sebestyén, Anna ; L Kiss, Anna ; Pálóczi, Krisztina

Tumors are intricate ecosystems where cancer cells and non-malignant stromal cells, including cancer-associated fibroblasts (CAFs), engage in complex communication. In this study, we investigated the interaction between poorly (HLE) and well-differentiated (HuH7) hepatoma cells and LX2 fibroblasts. We explored various communication channels, including soluble factors, metabolites, extracellular vesicles (EVs), and miRNAs. Co-culture with HLE cells induced LX2 to produce higher levels of laminin β1, type IV collagen, and CD44, with pronounced syndecan-1 shedding. Conversely, in HuH7/LX2 co-culture, fibronectin, thrombospondin-1, type IV collagen, and cell surface syndecan-1 were dominant matrix components. Integrins α6β4 and α6β1 were upregulated in HLE, while α5β1 and αVβ1 were increased in HuH7. HLE-stimulated LX2 produced excess MMP-2 and 9, whereas HuH7-stimulated LX2 produced excess MMP-1. LX2 activated MAPK and Wnt signaling in hepatoma cells, and conversely, hepatoma-derived EVs upregulated MAPK and Wnt in LX2 cells. LX2-derived EVs induced over tenfold upregulation of SPOCK1/testican-1 in hepatoma EV cargo. We also identified liver cancer-specific miRNAs in hepatoma EVs, with potential implications for early diagnosis. In summary, our study reveals tumor type-dependent communication between hepatoma cells and fibroblasts, shedding light on potential implications for tumor progression. However, the clinical relevance of liver cancer-specific miRNAs requires further investigation.

01 Nov 2022·Annals of Vascular Surgery

Correlation Between Proteolytic Activity and Abdominal Aortic Aneurysm Wall Morphology with Intraluminal Thrombus Volume

Article

Author: Sladojevic, Milos ; Isakovic, Aleksandra ; Koncar, Igor ; Vidicevic Novakovic, Sasenka ; Tasic, Jelena ; Davidovic, Lazar ; Stanojevic, Zeljka ; Zlatanovic, Petar ; Mutavdzic, Perica ; Matejevic, David ; Tomic, Ivan

BACKGROUNDThe aim of this study was to examine the influence of intraluminal thrombus (ILT) volume on the level of proteolytic activity and the content of abdominal aortic aneurysm (AAA) wall.METHODSThe research was designed as a cross-sectional study at the Clinic for Vascular and Endovascular Surgery, Clinical Center of Serbia in the period from April 2017 to February 2018. During this period, a total of 155 patients with asymptomatic AAA underwent open surgical treatment and 50 were included in the study based on inclusion and exclusion criteria. Before surgery, patients included in the study were examined by MRI. During the operation, samples of ILT and AAA wall were taken for biochemical analysis.RESULTSA statistically significant correlation was found between the volume of the ILT and largest AAA diameter (ρ = 0.56; P < 0.001). The correlation of the ILT volume on the anterior wall and the concentration of MMP-9, MMP-2 and NE/ELA in the wall did not find statistical significance. Also, no statistically significant association was found between the volume of ILT and the concentration of ECM proteins (collagen type 3, elastin, proteoglycan) in the corresponding part of the wall. The association of ILT volume with MDA was also of no statistical significance. There was a positive statistical significance found in correlation of volume of ILT and catalase activity in the wall of AAA (ρ = 0.28, P = 0.049).CONCLUSIONSThe volume of ILT in the aneurysmal sac seemed not to affect the level of proteolytic activity and the content of the aneurysm wall. However, a positive correlation was found between the ILT and the catalase activity. The effect of ILT on the aneurysm wall and its role in the progression of aneurysmal disease should be examined in future studies.

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