Request Demo

Last update 23 Jan 2025

SEB

Last update 23 Jan 2025

Basic Info

Synonyms-

Introduction-

Drugs associated with SEB

Aptamer Antagonist A11

Target

SEB

Mechanism

SEB inhibitors

Active Org.

900th Hospital of Joint Logistics Support Force of PLA

Originator Org.

900th Hospital of Joint Logistics Support Force of PLA

Active Indication

Shock, Septic

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

HuMAb-154

Target

SEB

Mechanism

SEB inhibitors

Active Org.

Morphotek, Inc.

Originator Org.

Morphotek, Inc.

Active Indication

Staphylococcal Infections

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

MORAb-048

Target

SEB

Mechanism

SEB inhibitors

Active Org.

Morphotek, Inc. [+1]

Originator Org.

U.S. Army Medical Research Institute for Infectious Diseases

Active Indication

Staphylococcal Infections

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with SEB

100 Translational Medicine associated with SEB

0 Patents (Medical) associated with SEB

2,190

Literatures (Medical) associated with SEB

01 Apr 2025·Academic Pediatrics

Longitudinal Stability and Predictive Value of Socio/Emotional/Behavioral Screening in an Outpatient Pediatric Network

Article

Author: Hirshfeld-Becker, Dina R ; Holcomb Scarpelli, Juliana M ; Sheldrick, R Christopher ; Dutta, Anamika ; Boudreau, Alexy Arauz ; Birudavol, Justin ; Murphy, J Michael ; Jellinek, Michael S ; Perrin, Ellen C ; Benheim, Talia S ; Carter, Alice S

BACKGROUNDIn 2022, the American Academy of Pediatrics recommended annual social/emotional/behavioral (SEB) screening at preventive pediatric visits. Numerous SEB screeners have considerable empirical support for children of all ages. However, few studies inform the longitudinal use of SEB screeners in pediatrics.METHODSUsing electronic health records (EHR) from seven pediatric clinics in a large hospital system, we analyze the longitudinal stability of three SEB screeners among 9153 children and adolescents who were screened multiple times over a 3-year period, and we evaluate associations with International Classification of Disease (ICD) codes for SEB diagnoses.RESULTSModerate stability was documented for the Baby Pediatric Symptom Checklist (intraclass correlation coefficient [ICC]=.57), Preschool Pediatric Symptom Checklist (ICC=.60), and Pediatric Symptom Checklist-17 (ICC=.69). Stability of positive/negative results was sensitive to each screener's threshold. Across a range of thresholds that classify 7-20% of children as positive, all three screeners achieved positive predictive values (PPVs) of approximately 40-65% and diagnostic odds ratios ranging from 8 to 15. These findings compare favorably to published results for longer measures and structured interviews. Recommended thresholds varied markedly across screeners, and associations with ICD codes demonstrate that higher thresholds yield higher specificity but lower sensitivity (ie, a majority of ICD codes are not anticipated by positive screens).CONCLUSIONSThree common SEB screeners display longitudinal stability similar to longer, more established measures. Results demonstrate that recommended thresholds vary markedly across measures and that choice of threshold strongly influences sensitivity and specificity, underscoring the need for greater attention to selection of thresholds.

01 Feb 2025·Food Chemistry

Magnetic-plasmonic blackbody enhanced lateral flow immunoassay of staphylococcal enterotoxin B

Article

Author: Sun, Jiayi ; Peng, Juan ; Wang, Xiaolong ; Fan, Xinya ; Wu, Yuhao ; Huang, Xiaolin ; Xiong, Yonghua

Staphylococcal enterotoxin B (SEB) in food is a serious health risk, making rapid and accurate detection methods essential. Herein, we synthesized a magnetic plasmonic blackbody, Fe₃O₄@Au/PDA, by coating a gold/polydopamine (Au/PDA) layer onto an Fe₃O₄ core. This Fe₃O₄@Au/PDA exhibits broadband absorption, excellent stability, and rapid magnetic response, making it ideal for use as a magnetic separation tool and colorimetric signal amplifier. We integrated Fe₃O₄@Au/PDA into a lateral flow immunoassay (LFIA) for ultrasensitive SEB detection, combining magnetic enrichment with enhanced colorimetric signal output. The Fe₃O₄@Au/PDA-based LFIA achieved a detection limit of 0.19 ng/mL, approximately 41 times lower than traditional gold nanoparticle-based LFIA. Its real-world applicability was tested in various food samples (milk, milk powder, apple juice, and lettuce) with recoveries between 82.4 % and 111.2 % and a coefficient of variation below 12.6 %. Collectively, the designed Fe₃O₄@Au/PDA shows great promise as a novel multifunctional signal amplification label, advancing the design and development of ultrasensitive LFIA for various fields, such as food safety detection.

01 Feb 2025·Journal of Food Protection

Prevalence and Characterization of Staphylococcus aureus Isolated from Meat and Milk in Northeastern Italy

Article

Author: Briandet, Roman ; Bianco, Silvia ; Dechamps, Julien ; Maifreni, Michela ; Manzano, Marisa ; Anba-Mondoloni, Jamila ; Vidic, Jasmina ; Domi, Beki ; Pinamonti, Debora ; Ferrin, Alessia

Staphylococcus aureus is a pathogenic microorganism often found in animal-derived foods and is known for its ability to readily develop resistance to antibiotic treatments. This study was designed to determine the prevalence of S. aureus strains in raw milk and meat in Italy and to evaluate their antibiotic resistance profiles and biofilm production. Among the meat isolates, 41.67% were resistant to ampicillin, and 25% were methicillin-resistant S. aureus (MRSA). In milk, 20% of the isolates were resistant to gentamycin, while 5.71% were MRSA. The prevalence of multidrug-resistant strains was higher in meat (16.67%) compared to milk (5.71%). The biofilm formation capability was assessed in most of the isolates (80% in milk and 100% in meat). Representative strains exhibiting different antibiotic resistance profiles were all negative for the enterotoxin genes sea, seb, sec, sed, and see, but harbored potential virulence factors such as hemolytic activity, high pigmentation, low cell envelop permeability, charged and hydrophobicity. Finally, the interaction of representative strains with human Caco-2 intestinal cell line showed that most strains had an adhesion capacity. Our findings reveal that foodborne isolates of S. aureus present a considerable threat to consumers due to their production of virulence factors, which enhance their pathogenicity and increase the likelihood of antibiotic treatment failures.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

SEB

Basic Info

Related

Analysis