Last update 01 Nov 2024

STK4 x MST2

Last update 01 Nov 2024

Basic Info

Related Targets

STK4MST2

Drugs associated with STK4 x MST2

XMU-MP-1

Target

MST2 x STK4

Mechanism

MST2 modulators [+1]

Active Org.-

Originator Org.

Xiamen University

Active Indication-

Inactive Indication

Liver Injury

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with STK4 x MST2

100 Translational Medicine associated with STK4 x MST2

0 Patents (Medical) associated with STK4 x MST2

Literatures (Medical) associated with STK4 x MST2

01 Jan 2024·Digestive Diseases

Association Study between SNPs in MST1 and MST2 and H. pylori Infection as well as Noncardia Gastric Carcinogenesis

Article

Author: Gao, Fang ; Jia, Yanbin ; Dong, Wenjie ; Ma, Licong ; Song, Qiang

Introduction: Gastric cancer (GC) remains a global health challenge, and H. pylori infection is a main risk factor for noncardia GC. The present study aimed to investigate the association between single nucleotide polymorphisms (SNPs) in mammalian sterile 20-like kinase 1 (MST1) and MST2, H. pylori (H. pylori) infection, and the risk of noncardia gastric cancer (GC). Methods: A case-control study was conducted using enzyme-linked immunosorbent assay (ELISA) and TaqMan method to detect the titer of anti-H. pylori antibody in normal human serum and genotype 9 SNPs of MST1 and MST2 genes among 808 samples. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between SNPs and H. pylori infection, as well as the risk of noncardia gastric cancer in codominant, dominant, overdominant, recessive, and log-additive genetic models. Haplotypes were constructed using the Haploview 4.2 software. Results: The CC genotype of MST2 SNP rs10955176 was associated with a reduced risk of H. pylori infection compared to the TT + CT genotype. None of other SNPs were associated with H. pylori infection. The TT genotype of MST2 SNP rs7827435 was associated with a reduced risk of noncardia gastric cancer compared to the AA + AT genotype. None of the SNPs were associated with noncardia gastric cancer. There were no associations between haplotypes and H. pylori infection or the risk of noncardia gastric cancer. Conclusions: The CC genotype of rs10955176 and the TT genotype of rs7827435 may serve as protective factors against H. pylori infection and noncardia gastric cancer risk, respectively.

01 Aug 2023·Allergy

Stk4, a key regulator in regulatory T cells homeostasis activity?

Author: Tomei, Leonardo ; Céspedes, Jose Antonio

A review.Regulatory T cells (Tregs) play an essential role modulating immune response through the surface marker expression and mediators′ release.Dysregulation in Treg numbers or dysfunction associated with allergy and autoimmune and inflammatory disorders development.Since the deficit of Stk4 has been associated with an increase in infections, autoimmunity, and immune dysregulation, its potential role modulating the activity of Tregs seems clear, although the concrete mechanism remains elusive.In this work, nine Stk4- deficient patients had atopic dermatitis, recurrent pneumonia, and cutaneous viral infections.Cui et al. In their work, Stk3/4-deficient mouse model showed a severe inflammation, with decreased Tregs numbers, expansion of effector memory T cell, and dysregulated interferon-γ (IFN-γ) expression.Concerning the stabilization complex by phosphorylation, Ye Cui et al. studied the colocation of FoxP3 with Stk4/p65 complex in Tregs with phosphomimetic residue in comparison to a phosphorylation-resistant cell, and the first one was more associated with the Stk4/ p65 complex than the resistant one.However, it is not entirely clear if Stk4 stabilizes Stk4-Foxp3-p65 complex formation.Patients with different loss-of-function mutations in Stk4 suffered a decrease in naive and central memory Tregs populations and an increase in effector Tregs populations without affecting the number of Tregs.Even though this article showed the potential role of Stk4 as regulatory activity of Tregs, more research is needed, as it was focused on a mouse model, and only in five patients.Furthermore, it is not completely clear how Stk4, but not Stk3, have a role controlling their activity.

01 Apr 2023·Fish & Shellfish Immunology

Comparative genomics studies on the stk gene family in vertebrates: From the bighead carp (Hypophthalmichthys nobilis) genome

Article

Author: Ma, Caifeng ; Chen, Rongrong ; Mao, Yang ; Zhang, Kebin ; Li, Defeng ; Xiong, Junzhi

The mammalian sterile 20-like (MST) family belongs to the serine/threonine protein kinase (STK) superfamily and participates in a variety of biological processes, such as cell apoptosis, polarity, migration, immune regulation, inflammatory responses, and cancer. In the economically important bighead carp (Hypophthalmichthys nobilis), the STK gene family and immune-related biological functions may be helpful in increasing its economic yield. However, the comprehensive role of STKs in the bighead carp remains unclear. In this study, the five stk sequences from the bighead carp were divided into two classes: stk3/4 and stk24/25/26. Gene structure and motif prediction analyses confirmed that stk is conserved in the bighead carp. Compared to 26 other vertebrate species, teleosts (including bighead carp) possess more stk members because of teleost-specific whole-genome duplication. Synteny analysis revealed that stk3, stk24, stk25, and stk26 have been relatively conserved in bighead carp during evolution. Meanwhile, stk4 was lost in most Cyprinid species, including bighead carp, during evolution. RNA-seq data revealed that STK expression was associated with various pathogens, and the expression of these STKs (Hnstk3, Hnstk24a, Hnstk24b, Hnstk25, and Hnstk26) was different in seven tissues of bighead carp. In addition, we showed that STK expression levels were dramatically altered in the head kidney and that stk24 was involved in defense against Aeromonas hydrophila. This study provides a molecular basis for the analysis of stk function in bighead carp, and can be used as a reference for further phylogenomics.

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