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Last update 08 May 2025

IBSP

Last update 08 May 2025

Basic Info

Synonyms

BNSP, Bone sialoprotein 2, Bone sialoprotein II

+ [8]

Introduction

Binds tightly to hydroxyapatite (PubMed:11459848). Appears to form an integral part of the mineralized matrix (PubMed:1818768). Probably important to cell-matrix interaction (PubMed:1818768). Promotes adhesion and migration of various cells via the alpha-V/beta-3 integrin receptor (ITGAV:ITGB3) (PubMed:10640428, PubMed:11459848, PubMed:24103036).

Drugs associated with IBSP

TGC-9

Target

IBSP

Mechanism

IBSP inhibitors

Active Org.-

Originator Org.

German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)

Active Indication-

Inactive Indication

Neoplasms

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with IBSP

100 Translational Medicine associated with IBSP

0 Patents (Medical) associated with IBSP

2,420

Literatures (Medical) associated with IBSP

01 Jun 2025·Journal of Oral Biosciences

Impact of enamel matrix proteins combined with collagen membranes on osteoblastic cell cultures

Article

Author: Silva, Vanessa Cordeiro ; Aquino, Iara Gonçalves ; Teixeira, Lucas Novaes ; Matos, Gabrielle Moreira ; Spinola de Castro Raucci, Larissa Moreira ; Soares, Andresa Borges ; Cavalcanti de Araújo, Vera ; Martinez, Elizabeth Ferreira

OBJECTIVEBiodegradable collagen membranes are widely used in guided bone regeneration. This study evaluated the effect of enamel matrix proteins (Emdogain®) combined with two collagen membranes (Bio-Gide® or Collprotect®) on osteoblastic cell cultures.METHODSHuman osteoblastic cells were cultured on Bio-Gide® or Collprotect® membranes coated with Emdogain® or left uncoated. The assessed parameters included amelogenin quantification at 1 h, 12 h, 1 day, 3 days, and 7 days; cell morphology at 1 day; cell proliferation at 1, 2, and 3 days; gene expression of COL1A1, IBSP, SPP1, and BGLAP at 1 day; Collagen type I quantification at 3 and 7 days; alkaline phosphatase (ALP) activity at 3 and 7 days; and mineralization at 14 days. Data were analyzed using two-way analysis of variance or the Kruskal-Wallis test.RESULTSHigher amelogenin levels were detected in Bio-Gide® cultures than in Collprotect® cultures after 3 and 7 days. Cells adhered and spread in all experimental groups. Cell proliferation was higher in Bio-Gide® cultures after 3 days (p<0.05). Gene expression of COL1A1, IBSP, and SPP1 was greater in Bio-Gide® cultures with Emdogain® after 1 day. There was higher collagen type I secretion by cultures grown on collagen membranes coated with Emdogain®, particularly on Bio-Gide® cultures at 7 days. ALP activity was also higher in Bio-Gide® cultures at 7 days (p<0.05). Greater mineralization was detected in cultures grown on Bio-Gide® with Emdogain® (p<0.05).CONCLUSIONCombining collagen membranes, particularly Bio-Gide®, with enamel matrix proteins promotes osteogenesis in vitro, potentially advancing bone tissue regeneration and preservation methods.

01 Jun 2025·Regenerative Therapy

Selective effects of collagen-derived peptides Pro-Hyp and Hyp-Gly on the proliferation and differentiation of SSEA3-positive human dental pulp stem cells

Article

Author: Ntege, Edward Hosea ; Nakamura, Hiroyuki ; Isa, Mikana ; Suzuki, Risako ; Murahashi, Makoto ; Ide, Kentaro ; Tokuchi, Shusuke ; Kawano, Toshihiro ; Shimizu, Yusuke ; Sunami, Hiroshi

IntroductionCollagen-derived peptides demonstrate diverse biological activities, but their effects on human dental pulp stem cells (hDPSCs) remain unclear. This study investigated the influence of prolyl-hydroxyproline (Pro-Hyp) and hydroxyproline-glycine (Hyp-Gly) on stage-specific embryonic antigen 3 (SSEA3)-positive hDPSCs.MethodsSSEA3-positive and SSEA3-negative hDPSCs were isolated and cultured with Pro-Hyp or Hyp-Gly (200 μg/ml) under stem cell medium or differentiation-inducing conditions. Cell proliferation was assessed using the MTT assay. The expression of the chondrogenic and osteogenic markers was analyzed by real-time PCR. Matrix production was evaluated using Alcian blue and Alizarin red S staining.ResultsPro-Hyp and Hyp-Gly enhanced the proliferation of SSEA3-positive hDPSCs compared with SSEA3-negative cells. Pro-Hyp promoted chondrogenic differentiation through early upregulation of Col II followed by sustained SOX9 expression, with enhanced matrix production after 2 weeks in chondrogenic medium. Hyp-Gly specifically enhanced the osteogenic differentiation of SSEA3-positive cells through the temporal regulation of gene expression, progressing from early transcription factors (RUNX2 and RANKL) to matrix proteins (ALPL, Col I, BSP, and OCN), resulting in increased mineralization under osteogenic conditions.ConclusionsThis study demonstrated that Pro-Hyp and Hyp-Gly selectively influenced SSEA3-positive hDPSC fate through the distinct temporal regulation of differentiation pathways. These findings provide new insights into the development of targeted regenerative strategies using collagen-derived peptides in dental tissue engineering.

01 Jun 2025·Matrix Biology Plus

Small Integrin binding Ligand N-linked Glycoproteins, prostate-specific antigen and time to prostate cancer diagnosis

Article

Author: Jain, Alka ; Simonsick, Eleanor M ; Metter, E Jeffrey ; Ogbureke, Kalu U ; Fedarko, Neal S ; Fisher, Larry W ; Ni, Ying ; Zhang, Daisy

BACKGROUNDSmall Integrin Binding Ligand N-linked Glycoproteins (SIBLINGs¹) were associated with cancer in cross-sectional studies. Whether SIBLINGs associate with preclinical disease is unknown.METHODSA retrospective longitudinal case control study was performed to determine the association of SIBLINGs and prostate-specific antigen (PSA) with preclinical disease. Paired serum samples from 109 cancer-free Baltimore Longitudinal Study on Aging participants were divided into those that were either most distal or proximal to diagnosis (cases) or censored (controls). Dentin sialophosphoprotein (DSPP), bone sialoprotein (BSP), osteopontin (OPN), and PSA were measured by immunoassay and dichotomized into low or high based on their respective cut-off values. Associations of time to diagnosis or death, modeled as disease-free survival (DFS) or overall survival (OS), were assessed using Kaplan Meier and Cox proportional hazard survival estimates on individual and aggregated biomarkers in distal or proximal sets separately. Models were adjusted for relevant covariates. A false discovery rate analysis assessed significance of hazard ratios (HRs) in sets.RESULTSBiomarkers/aggregates identified as true discoveries for DFS included DSPP + PSA, OPN + PSA, DSPP + BSP + PSA, DSPP + OPN + PSA, where unadjusted distal HRs ranged between 11 and 27 and after adjusting for age from 7 to 15, while proximal HRs ranged between 6 and 10 unadjusted and 5 to 12 after adjusting for age. For proximal OS, true discoveries included DSPP + BSP, DSPP + OPN, DSPP + BSP + OPN, and DSPP + OPN + PSA where unadjusted HRs ranged between 6 and 20 while age-adjusted HRs ranged between 5 and 12.CONCLUSIONSThese observations support SIBLINGs as biomarkers that associate with DFS and OS in prediagnosis samples.

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IBSP

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