Last update 01 Nov 2024
LYPLA2
Last update 01 Nov 2024
Basic Info
Synonyms Acyl-protein thioesterase 2, APT-2, APT2 + [6] |
Introduction Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951). |
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100 Clinical Results associated with LYPLA2
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100 Translational Medicine associated with LYPLA2
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01 Dec 2024Food Chemistry
Novel self-powered sandwich type Aptamer sensor for estrogen detection assisted with peroxidase mimic Cu-MOF
Article
Author: Xu, Qin ; Hu, Xiaoya ; Wang, Zheng ; Ning, Kangping ; Qin, Honglan ; Azat, Seitkhan ; Ahmed, Maruf ; Yang, Dandan
01 Sep 2024Biochemical and Biophysical Research Communications
Identification of a novel target of sulforaphane: Sulforaphane binds to acyl-protein thioesterase 2 (APT2) and attenuates its palmitoylation
Article
Author: Yamamoto, Yuji ; Inoue, Jun ; Kamada, Haruhiko ; Kikuchi, Akito ; Kodaka, Manami ; Ishigami, Ken ; Katsuta, Ryo ; Kawahira, Kotaro ; Suzuki, Tsukasa
01 Sep 2024Molecular Cell
Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity
Article
Author: Wang, Huan ; Jiang, Qiwei ; Bu, Lang ; Zhou, Zhengran ; Zhang, Shuishen ; Cheng, Chao ; Zhang, Yi ; Liu, Miaowen ; Zhang, Zhengkun ; Guo, Jianping ; Wu, Xueji ; Wang, Lei ; Xie, Wei ; He, Miao
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