Last update 08 May 2025

MFSD8

Basic Info

Synonyms
Ceroid-lipofuscinosis neuronal protein 7, CLN7, major facilitator superfamily domain containing 8
+ [3]
Introduction
Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions.

Analysis

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