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Last update 08 May 2025

DGCR2

Last update 08 May 2025

Basic Info

Synonyms

DGCR2, DGS-C, DiGeorge syndrome critical region gene 2

+ [5]

Introduction

Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.

Drugs associated with DGCR2

WO2024175805

Patent Mining

Target

DGCR2

Mechanism-

Active Org.

Hannover Medical School [+1]

Originator Org.

Technische Universität Braunschweig [+1]

Active Indication

Immune System Diseases

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with DGCR2

100 Translational Medicine associated with DGCR2

0 Patents (Medical) associated with DGCR2

122

Literatures (Medical) associated with DGCR2

01 Jun 2025·Bioorganic Chemistry

Unveiling a pyrroloindoline diketopiperazine biosynthetic pathway featuring a phytoene-synthase-like family prenyltransferase with distinct regioselectivity

Article

Author: Li, Wenli ; Duan, He ; Zhang, Meifang ; Xiao, Fei ; Chen, Zhenshan ; Wang, Xin

Pyrroloindoline-containing natural products are a group of molecules with diverse biological activities. Herein, we identified a cryptic cyclodipeptide synthase (CDPS) gene cluster (lan) from a deepsea-derived Streptomyces strain using the phytoene-synthase-like (PSL) family prenyltransferase (PT) as a probe. Heterologous expression of the lan gene cluster in Streptomyces albus J1074 led to the production of two reversely C5'-prenylated pyrroloindoline-containing diketopiperazines (DKPs), lansais A (4) and B (5). Gene inactivation and biochemical assays established its biosynthetic pathway as follows: LanA, a fused CDPS-methyltransferase, sequentially generates mono- and bis-pyrroloindoline intermediates (2 and 3) viacyclo (l-Trp-l-Trp) formation and C3/C3'-methylation; subsequently, N-methyltransferase LanC installs the methyl group at N1/N1' followed by installation of the prenyl moiety at C5' by the PSL family PT LanB. Notably, compounds 4 and 5 demonstrated potent anti-vesicular stomatitis virus (VSV) activity, with a 50 % virus inhibitory concentration (IC₅₀) values of 1.98-2.22 μM, significantly stronger than that of ribavirin (IC₅₀ = 14.27 μM), revealing the critical role of the prenyl moiety in anti-VSV activity. Taking advantage of the catalytic promiscuity of LanB, two new lansai derivatives with C5'-reverse or C7'-regular dimethylallyl moiety (9 and 10) were obtained, achieving IC₅₀ value as low as 0.31 μM (10). Of note, the regioselectivity of LanB is distinct from all the other reported PSL family PTs. Our study enriches the biosynthetic machineries of pyrroloindoline-containing DKPs, and lays the foundation for further increasing the structural diversity of this compound family.

01 Mar 2025·Immunohematology

An update on the LAN blood group system

Review

Author: Castilho, Lilian

AbstractThis update on the LAN blood group system (Peyrard T. A review of the Lan blood group system. Immunohematology 2013; 29:131–5) reports new ABCB6 alleles encoding Lan– and Lan(+wk) phenotypes and new functional aspects of the ABCB6 glycoprotein. The L AN blood group system (International Society of Blood Transfusion system 33) consists of one antigen: Lan.

01 Dec 2024·Neuroscience Bulletin

Compensation or Preservation? Different Roles of Functional Lateralization in Speech Perception of Older Non-musicians and Musicians

Article

Author: Wu, Guowei ; Jin, Xinhu ; Wang, Xiuyi ; Du, Yi ; Zhang, Lei

AbstractMusical training can counteract age-related decline in speech perception in noisy environments. However, it remains unclear whether older non-musicians and musicians rely on functional compensation or functional preservation to counteract the adverse effects of aging. This study utilized resting-state functional connectivity (FC) to investigate functional lateralization, a fundamental organization feature, in older musicians (OM), older non-musicians (ONM), and young non-musicians (YNM). Results showed that OM outperformed ONM and achieved comparable performance to YNM in speech-in-noise and speech-in-speech tasks. ONM exhibited reduced lateralization than YNM in lateralization index (LI) of intrahemispheric FC (LI_intra) in the cingulo-opercular network (CON) and LI of interhemispheric heterotopic FC (LI_he) in the language network (LAN). Conversely, OM showed higher neural alignment to YNM (i.e., a more similar lateralization pattern) compared to ONM in CON, LAN, frontoparietal network (FPN), dorsal attention network (DAN), and default mode network (DMN), indicating preservation of youth-like lateralization patterns due to musical experience. Furthermore, in ONM, stronger left-lateralized and lower alignment-to-young of LI_intra in the somatomotor network (SMN) and DAN and LI_he in DMN correlated with better speech performance, indicating a functional compensation mechanism. In contrast, stronger right-lateralized LI_intra in FPN and DAN and higher alignment-to-young of LI_he in LAN correlated with better performance in OM, suggesting a functional preservation mechanism. These findings highlight the differential roles of functional preservation and compensation of lateralization in speech perception in noise among elderly individuals with and without musical expertise, offering insights into successful aging theories from the lens of functional lateralization and speech perception.

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DGCR2

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