Last update 01 Nov 2024

PTPRD

Last update 01 Nov 2024

Basic Info

Synonyms

HPTP, protein tyrosine phosphatase receptor type D, Protein-tyrosine phosphatase delta

+ [4]

Introduction

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.

Drugs associated with PTPRD

Anti-PTPRD antibody(Cold Spring Harbor Laboratory)

Target

PTPRD

Mechanism

PTPRD inhibitors

Active Org.

Cold Spring Harbor Laboratory, Inc.

Originator Org.

Cold Spring Harbor Laboratory, Inc.

Active Indication

Breast Cancer

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

NHB-1109

Target

PTPRD

Mechanism

PTPRD inhibitors

Active Org.

The University of New Mexico [+1]

Originator Org.

University of Maryland School of Medicine

Active Indication

Unspecified drug dependence

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with PTPRD

100 Translational Medicine associated with PTPRD

0 Patents (Medical) associated with PTPRD

441

Literatures (Medical) associated with PTPRD

18 Oct 2024·Nanomaterials (Basel, Switzerland)

Exploring the Potential of Bimetallic PtPd/C Cathode Catalysts to Enhance the Performance of PEM Fuel Cells.

Article

Author: Guterman, Vladimir ; Menshikov, Vladislav ; Alekseenko, Anastasia ; Novomlinskaya, Irina ; Paperzh, Kirill ; Belenov, Sergey ; Pankov, Ilya ; Moguchikh, Elizaveta

Bimetallic platinum-containing catalysts are deemed promising for electrolyzers and proton-exchange membrane fuel cells (PEMFCs). A significant number of laboratory studies and commercial offers are related to PtNi/C and PtCo/C electrocatalysts. The behavior of PtPd/C catalysts has been studied much less, although palladium itself is the metal closest to platinum in its properties. Using a series of characterization methods, this paper presents a comparative study of structural characteristics of the commercial PtPd/C catalysts containing 38% wt. of precious metals and the well-known HiSpec4000 Pt/C catalyst. The electrochemical behavior of the catalysts was studied both in a three-electrode electrochemical cell and in the membrane electrode assemblies (MEAs) of hydrogen-air PEMFCs. Both PtPd/C samples demonstrated higher values of the electrochemically active surface area, as well as greater specific and mass activity in the oxygen reduction reaction in comparison with conventional Pt/C, while not being inferior to the latter in durability. The MEA based on the best of the PtPd/C catalysts also exhibited higher performance in single tests and long-term durability testing. The results of this study conducted indicate the prospects of using bimetallic PtPd/C materials for cathode catalysts in PEMFCs.

06 Sep 2024·Journal of Proteome Research

Proteomics and Metabolic Characteristics of Boar Seminal Plasma Extracellular Vesicles Reveal Biomarker Candidates Related to Sperm Motility

Article

Author: Ding, Ning ; Zhang, Yu ; Jiang, Li ; Liu, Jianfeng ; Cao, Jinkang ; Zhang, Chun ; Zhang, Jing

Although seminal plasma extracellular vesicles (SPEVs) play important roles in sperm function, little is known about their metabolite compositions and roles in sperm motility. Here, we performed metabolomics and proteomics analysis of boar SPEVs with high or low sperm motility to investigate specific biomarkers affecting sperm motility. In total, 140 proteins and 32 metabolites were obtained through differentially expressed analysis and weighted gene coexpression network analysis (WGCNA). Seven differentially expressed proteins (DEPs) (ADIRF, EPS8L1, PRCP, CD81, PTPRD, CSK, LOC100736569) and six differentially expressed metabolites (DEMs) (adenosine, beclomethasone, 1,2-benzenedicarboxylic acid, urea, 1-methyl-l-histidine, and palmitic acid) were also identified in WGCNA significant modules. Joint pathway analysis revealed that three DEPs (GART, ADCY7, and NTPCR) and two DEMs (urea and adenosine) were involved in purine metabolism. Our results suggested that there was significant correlation between proteins and metabolites, such as IL4I1 and urea (r = 0.86). Furthermore, we detected the expression level of GART, ADCY7, and CDC42 in sperm of two groups, which further verified the experimental results. This study revealed that several proteins and metabolites in SPEVs play important roles in sperm motility. Our results offered new insights into the complex mechanism of sperm motility and identified potential biomarkers for male reproductive diseases.

01 Sep 2024·Nature Neuroscience

Cerebellar Purkinje neurons enhance thirst via asprosin–PTPRD signaling

Article

Independent of its appetite- and body weight-modulating effects, the hormone asprosin activates its receptor PTPRD at cerebellar Purkinje neurons to enhance thirst and maintain fluid homeostasis.Surprisingly, this has no effect whatsoever on Purkinje neuron-mediated motor coordination and learning.

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