Request Demo

Last update 23 Jan 2025

PTPRD

Last update 23 Jan 2025

Basic Info

Synonyms

HPTP, protein tyrosine phosphatase receptor type D, Protein-tyrosine phosphatase delta

+ [4]

Introduction

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2.

Drugs associated with PTPRD

NHB-1109

Target

PTPRD

Mechanism

PTPRD inhibitors

Active Org.

The University of New Mexico [+1]

Originator Org.

University of Maryland School of Medicine

Active Indication

Unspecified drug dependence

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Anti-PTPRD antibody(Cold Spring Harbor Laboratory)

Target

PTPRD

Mechanism

PTPRD inhibitors

Active Org.

Cold Spring Harbor Laboratory, Inc.

Originator Org.

Cold Spring Harbor Laboratory, Inc.

Active Indication

Breast Cancer

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with PTPRD

100 Translational Medicine associated with PTPRD

0 Patents (Medical) associated with PTPRD

455

Literatures (Medical) associated with PTPRD

01 Apr 2025·Bioelectrochemistry

Label-free determination of glypican-3 using PtPd@H-rGO nanocomposites decorated light-addressable potentiometric sensor

Article

Author: Liang, Jintao ; Li, Wenzhan ; Li, Guiyin ; Zhou, Zhide ; Tan, Xiaohong ; Zhou, Yu ; Huang, Qing

Glypican-3 (GPC3) is exclusively overexpressed in most Hepatocellular carcinoma (HCC) tissue but not in normal liver tissue, making it a promising biomarker for the precise detection of HCC. In this paper, a label-free light-addressable potentiometric sensor (LAPS) decorated by platinumpalladium-hemin-reduced graphene oxide nanocomposites (PtPd@H-rGO NCs) was constructed for determination of GPC3. The GPC3 aptamer (GPC3_Apt) and PtPd@H-rGO NCs were modified on the surface of silicon-based LAPS chip to build sensitive unit of LAPS system. A readout photocurrent elicited from a modulated light source, registers the localized surface potential change. When a bias voltage is provided to the LAPS system, the GPC3-GPC3_Apt complexes formed by the specific reaction between GPC3 and GPC3_Apt at the sensing interface can cause the sensitive membrane surface potential to change, resulting in the photocurrent-voltage (I-V) curves generate a corresponding offset response. Therefore GPC3 concentration can be determined by monitoring the potential shifts (△V). Under optimal conditions, the potential shift is linearly related to the concentration of GPC3 in the range of 0.001-3.00 μg/mL with the limit of detection (LOD) of 0.0001 μg/mL. The LAPS has a good analytical performance with good specificity, reproducibility and stability, and can be used for the detection of GPC3 in actual serum samples, which provides a broad application prospect for the combined application of LAPS and aptamers in biooassay.

01 Jan 2025·Small

High‐Throughput UV‐Induced Synthesis and Screening of Alloy Electrocatalysts

Article

Author: Xie, Jiyang ; Gu, Chengding ; Cao, Jianyun ; Brandon, Nigel ; Li, Xu ; Li, Xiaohong ; Hu, Wanbiao ; Chen, Jiexin

AbstractThe combination of different elements in alloy catalysts can lead to improved activity as it provides opportunities to tune the electronic structures of surface atoms. However, the synthesis and performance screening of alloy catalysts through a vast chemical space are cost‐ and labor‐intensive. Herein, a UV‐induced, high‐throughput method is reported for the synthesis and screening of alloy electrocatalysts in a fast and low‐cost manner. A platform that integrates 37 mini‐reaction‐cells enables simultaneous UV‐induced photodeposition of alloy nanoparticles with up to 37 compositions. These mini‐reaction‐cells further allow a transfer‐free, high‐throughput electrochemical performance screening. Binary (PtPd, PtIr, PdIr), ternary (PtPdIr, PtRuIr) and quaternary (PtPdRuIr) alloys have been synthesized with the activity of the binary alloys (57 compositions) for hydrogen evolution reaction (HER) and oxygen reduction reaction (ORR) being screened. The predicted high performance of identified alloy compositions are subsequently validated by standard measurements using a rotating disk electrode configuration. It is found that the as‐synthesized alloy nanoparticles are rich in twin boundaries and thus possess lattice strain. Density functional theory calculation implies that the high ORR activity of the screened Pt0.75Pd0.25 alloy originates from the interplay between the differentiated adsorption sites because of alloying and the strain‐induced modulation of the d‐band center.

31 Dec 2024·Aging

Correction for: PTPRD mutation is a prognostic biomarker for sensitivity to ICIs treatment in advanced non-small cell lung cancer

Author: Wang, Li ; Leng, Chaohui ; Ren, Zhixuan

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

PTPRD

Basic Info

Related

Analysis