Last update 01 Nov 2024

CRYAB

Last update 01 Nov 2024

Basic Info

Synonyms

Alpha-crystallin B chain, Alpha(B)-crystallin, CRYA2

+ [6]

Introduction

May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity).

Drugs associated with CRYAB

NCI-41356

Target

CRYAB

Mechanism

CRYAB inhibitors

Active Org.

Université Bourgogne Franche-Comté

Originator Org.

Université Bourgogne Franche-Comté

Active Indication

Pulmonary Fibrosis

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

CAP-1160

Target

CRYAB x HSP

Mechanism

CRYAB stimulants [+1]

Active Org.

Plex Pharmaceuticals, Inc.

Originator Org.

Plex Pharmaceuticals, Inc.

Active Indication

Cataract

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with CRYAB

100 Translational Medicine associated with CRYAB

0 Patents (Medical) associated with CRYAB

1,581

Literatures (Medical) associated with CRYAB

01 Oct 2024·Biomedicine & Pharmacotherapy

Corrigendum to “Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy” [Biomed. Pharmacother. (2023) 160 114382]

Author: Du, Li-da ; Kong, De-Wen ; Lu, Yang ; Fang, Lian-Hua ; Yuan, Tian-Yi ; Wang, Ran-Ran ; Du, Guan-Hua ; Gong, Di-Fei ; Dawuti, Awaguli ; Sun, Shu-Chan ; Wang, Shou-Bao ; Liu, Rui-Qi

01 Oct 2024·Stem Cell Research

Generation of human induced pluripotent stem cell (hiPSC) lines derived from three patients carrying the pathogenic CRYAB (A527G) mutation and one non-carrier family member

Article

Author: Maas, Renee G C ; Verbueken, Devin ; Beekink, Tess ; Sluijter, Joost P G ; Kelters, Ilse R ; Van Laake, Linda W ; Buikema, Jan W

A newly identified pathogenic variant (A527G) in alpha B-crystallin (αB-crystallin) has been linked to congenital cataract and young-onset dilated cardiomyopathy (DCM) within a Dutch family, although the disease mechanism remains unclear. Four human induced pluripotent stem cell (hiPSC) clones were generated from three symptomatic patients carrying the A527G variant, and one healthy proband. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using integration-free Sendai viral pluripotency vectors. The established hiPSCs clones exhibited regular ESC-like morphology, expression of pluripotency markers, and normal karyotyping. These hiPSC lines can facilitate future studies to understand the chaperone function and its role in DCM disease progression.

01 Oct 2024·Heliyon

Effects of treadmill exercise on endoplasmic reticulum protein folding and endoplasmic reticulum-associated protein degradation pathways in APP/PS1 mice

Article

Author: Zhao, Na ; Zhang, Qiang ; Wang, Jing ; Xia, Jie ; Xu, Bo

A hallmark of Alzheimer's disease (AD) is the disruption of protein homeostasis (proteostasis), manifested by the misfolding and aggregation of proteins. Molecular chaperones and the endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway in the ER are essential for correct protein folding and degradation of misfolded proteins respectively, thus contributing to the maintenance of proteostasis. The present study aimed to investigate whether the beneficial effects of exercise in an AD mice model is associated with changes in ER protein folding and ERAD. APP/PS1 transgenic and wild-type mice were subjected to treadmill exercise for three months. The levels of molecular chaperones, specifically protein disulfide isomerases (PDIs) and heat shock proteins (HSPs), as well as ERAD-associated molecules were analyzed in the hippocampus. The result revealed a decrease in mRNA levels of PDIA2, PDIA3, PDIA4, PDIA5, PDIA6, HSPA1B, HSPA8, HSP90B1, DNAJB2, CRYAB, and CNX, an increase in mRNA levels of HSPA5 and HSPH1, an increase in protein levels of HERPUD1, and a decrease in protein levels of VCP in APP/PS1 mice. However, following a 3-month treadmill exercise regimen, an increase in mRNA levels of PDIA2, PDIA4, PDIA6, HSPA1A, HSPA8, HSP90AB1, and DNAJB2, as well as an increase in protein levels of VCP and DERL2, and a decrease in protein levels of HERPUD1 were noted. Overall, our findings indicate that disruptions in hippocampal ER protein folding and ERAD pathways may be implicated in AD, with exercise serving as a regulator of these pathways.

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CRYAB

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