BRD3

BEIJING, Nov. 12, 2024 /PRNewswire/ -- Tsingke has delivered high-quality biotechnology services and products to nearly 300,000 users globally. The number of high-level academic papers published using Tsingke's products and services has grown steadily year after year, continuously driving the advancement of life science research. We have selected two high-impact papers, published in prestigious journals, spanning a range of fields from gene function research to immunotherapy. Compilation of High-Impact Literature 1. Title: Enhancing rice panicle branching and grain yield through tissue-specific brassinosteroid inhibition DOI: 10.1126/science.adk8838 Journal: Science Impact Factor: 56.9 Summary: This study shows that crop yield potential is limited by inherent trade-offs between grain size and number. While brassinosteroids (BRs) promote grain enlargement, their role in regulating grain number has been unclear. By analyzing a cluster-type rice germplasm, the researchers found that activating the BR metabolic gene BRASSINOSTEROID-DEFICIENT DWARF3 (BRD3) significantly increases grain number. A molecular pathway was established where the BR signal inhibitor GSK3/SHAGGY-LIKE KINASE2 phosphorylates and stabilizes the OsMADS1 transcription factor, which targets the TERMINAL FLOWER1-like gene RICE CENTRORADIALIS2. Tissue-specific activation of BRD3 in secondary branch meristems enhances panicle branching, reduces the negative impact on grain size, and improves grain yield. The study demonstrates the powerful role of tissue-specific hormone manipulation in overcoming trait trade-offs and unlocking rice yield potential. 2. Title: Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer DOI: 10.1038/s41392-024-01772-w Journal: Signal Transduction and Targeted Therapy Impact Factor: 39.3 Summary: Despite the success of immune checkpoint therapies, resistance and relapse remain common in lung cancer. Cancer stem cells (CSCs) are an important factor in immune therapy resistance. Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, has shown synergistic effects with immunotherapy. This study shows that the key rate-limiting enzyme CPT1A in fatty acid oxidation, together with L-carnitine from tumor-associated macrophages, drives ferroptosis resistance and CD8+ T cell dysfunction in lung cancer. Mechanistically, CPT1A inhibits the ubiquitination and degradation of c-Myc, which transcriptionally activates CPT1A expression. The CPT1A/c-Myc positive feedback loop enhances the NRF2/GPX4 system and reduces the quantity of phospholipid polyunsaturated fatty acids, boosting cellular antioxidant capacity and suppressing ferroptosis in CSCs. Importantly, targeting CPT1A enhances anti-tumor immunity and ferroptosis in immune checkpoint blockade therapy in tumor-bearing mice. These results present a metabolic vulnerability-targeting approach to improve lung cancer immunotherapy efficacy. Tsynth™ Gene Synthesis Tsingke is built on a foundation of advanced gene synthesis technology, supported by a gene-smart molecular splitting and assembly platform that enhances accuracy and success rates. Leveraging years of expertise in life sciences, bioinformatics, and computer science, Tsingke has pioneered cutting-edge codon optimization techniques. At the same time, the company utilizes the propeller system (TSINGKE HELIXTECH), an integrated full-cycle management system that combines customer service, production management, and lean management. By employing AI algorithms, it effectively links raw materials, equipment, and processes, powering intelligent production lines and precise gene detection quality control techniques. This enables Tsingke to provide low-cost, high-efficiency, and high-quality gene synthesis services, meeting the needs of researchers in fields such as life science research, biopharmaceuticals, biological breeding, biomanufacturing, and gene storage. For more high-impact papers utilizing Tsingke's products and services, visit our website to explore how our solutions are helping advance research worldwide. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Bromodomain (BRDs) is a conserved protein structural domain that can specifically recognize acetylated lysine residues in proteins. Based on their structure and sequence similarity, 61 human bromodomains are classified into eight families, among which the BET family proteins, including BRD2, BRD3, BRD4, and BRDT are the most representative. The BET family bromodomain protein BRD4 contains acetylated lysine residues capable of binding chromatin and other proteins, which play a crucial role in gene regulation and cell growth control. BRD4 is associated with large protein complexes involved in regulating gene transcription, including mediator, PAFc, and super elongation complex, etc. The kinase activity of BRD4 can directly phosphorylate and activate RNA polymerase II, thereby regulating gene transcription expression. Many human diseases are closely related to BRD4 protein, such as tumors, autoimmune or inflammatory diseases, viral infections, and so on. BRD4 inhibitors target BRD4 for inhibition, which hold tremendous value in anti-cancer and anti-inflammatory sectors, as well as many other fields. It continues to attract the attention of major pharmaceutical companies and research institutions. BRD4 Competitive LandscapeAccording to the data provided by Patsnap Synapse-Global Drug Intelligence Database: the following figure shows that as of 8 Sep 2023, there are a total of 76 BRD4 drugs worldwide, from 62 organizations, covering 57 indications, and conducting 58 clinical trials. 👇Please click on the picture link below for free registration or login directly if you have freemium accounts, you can browse the latest research progress on drugs , indications, organizations, clinical trials, clinical results, and drug patents related to this target. The analysis of the target BRD4 reveals a competitive landscape with multiple companies actively involved in its development. Resverlogix Corp., Shenzhen Hepalink Pharmaceutical Group Co., Ltd., and Daiichi Sankyo Co., Ltd. are among the companies showing significant progress in their R&D efforts.  The approved indications for drugs targeting BRD4 cover a wide range of diseases, indicating its potential as a therapeutic target. Small molecule drugs and PROTACs are the drug types progressing most rapidly, suggesting intense competition in the market.  The countries/locations with active development include the United States, European Union, China, and others. China has shown progress in the development of BRD4 drugs.  Overall, the target BRD4 presents a promising opportunity for pharmaceutical companies, with a diverse range of indications and active research and development efforts worldwide. BRD4 Inhibitor in Phase III Clinical Trials: ApabetaloneApabetalone is a small molecule drug that targets BRD4, a protein involved in various cellular processes. It has shown potential therapeutic benefits in a wide range of therapeutic areas, including immune system diseases, infectious diseases, urogenital diseases, respiratory diseases, nervous system diseases, cardiovascular diseases, congenital disorders, endocrinology, and metabolic diseases. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. In terms of active indications, Apabetalone has demonstrated efficacy in COVID-19, coronary artery disease, type 2 diabetes mellitus, atherosclerosis, acute coronary syndrome, hypercholesterolemia, kidney failure, chronic, Fabry disease, prediabetic state, diabetic nephropathies, pulmonary arterial hypertension, and HIV infections. This suggests that the drug may have a broad spectrum of applications in treating various diseases and conditions. Apabetalone is developed by Resverlogix Corp., an originator organization specializing in the pharmaceutical industry. Currently, the drug is currently in Phase 3 of clinical development. This indicates that it has progressed through earlier stages of testing and is now being evaluated in larger populations to assess its safety and efficacy. Furthermore, Apabetalone has been granted Breakthrough Therapy designation, a regulatory status that recognizes its potential to provide significant benefits over existing treatments for serious or life-threatening conditions. This designation highlights the drug's potential to address unmet medical needs and expedite its development and review process. In summary, Apabetalone is a small molecule drug that targets BRD4 and has shown promise in various therapeutic areas, including immune system diseases, infectious diseases, urogenital diseases, respiratory diseases, nervous system diseases, cardiovascular diseases, congenital disorders, endocrinology, and metabolic diseases. It is currently in Phase 3 of development and has been granted Breakthrough Therapy designation, indicating its potential to address unmet medical needs. BRD4 inhibitor entering Phase II Clinical Trials: NHWD-870NHWD-870 is a small molecule drug developed by Ningbo Wenda Pharma. It is designed to target BRD4, a protein that plays a role in various diseases. The drug is currently in Phase 2 of clinical trials, both globally and in China. The therapeutic areas that NHWD-870 aims to address include neoplasms (abnormal growth of cells), immune system diseases, hemic and lymphatic diseases, skin and musculoskeletal diseases, and respiratory diseases. This indicates that the drug has potential applications in a wide range of medical conditions. 👇Please click on the image below to directly access the latest data (R&D Status | Core Patent | Clinical Trial | Approval status in Global countries) of this drug. The active indications for NHWD-870 are diffuse large B-cell lymphoma, melanoma (cutaneous malignant), non-Hodgkin lymphoma, non-small cell lung cancer, and small cell lung cancer. These are all serious and life-threatening diseases, highlighting the importance of developing effective treatments in these areas. Ningbo Wenda Pharma is the originator organization behind NHWD-870. As the developer of the drug, they are responsible for its research, development, and clinical trials. The fact that NHWD-870 has reached Phase 2 in both global and Chinese trials suggests that it has shown promising results in earlier stages of testing. Overall, NHWD-870 is a small molecule drug that targets BRD4 and has potential applications in various therapeutic areas, including neoplasms, immune system diseases, hemic and lymphatic diseases, skin and musculoskeletal diseases, and respiratory diseases. Its active indications include diffuse large B-cell lymphoma, melanoma, non-Hodgkin lymphoma, non-small cell lung cancer, and small cell lung cancer. Developed by Ningbo Wenda Pharma, NHWD-870 has reached Phase 2 in clinical trials, indicating its potential as a treatment option for these serious medical conditions.

SEATTLE, April 05, 2021 (GLOBE NEWSWIRE) -- SEngine Precision Medicine , a precision oncology company revolutionizing cancer therapies by pre-testing drugs on patient-derived tumor organoids, announced today that the PARIS® Test was utilized in a study to identify novel drug targets and combinations to combat ovarian clear cell carcinoma (OCCC). The study, “Targeting BET proteins BRD2 and BRD3 in combination with PI3K-AKT inhibition as a therapeutic strategy for ovarian clear cell carcinoma,” was recently published in American Association for Cancer Research’s Molecular Cancer Therapeutics and was co-authored by researchers from the Fred Hutchinson Cancer Research Center, SEngine Precision Medicine, Weill Cornell Medicine, and the University of Washington. Ovarian clear cell carcinoma, a relatively uncommon subtype of ovarian cancer, has historically been treated with the same platinum-based chemotherapies as patients with high grade serous carcinoma. However, clear cell carcinoma patients typically display a poorer response to chemotherapies, which leads to lower overall survival for these patients. In this study, researchers identified BET proteins BRD2 and BRD3 as novel targets against ovarian clear cell carcinoma, which could lead to more effective targeted therapies for this subtype. Additional drug sensitivity screening identified the combination of BET protein and PI3K-AKT pathway inhibitors as a promising therapeutic path for further investigation. SEngine’s PARIS® Test, a high-throughput drug sensitivity assay using patient-derived tumor organoids, was utilized in this study to validate the drug-response findings on ovarian cancer cell models. In addition to the PARIS® Test already being utilized as a clinical tool guiding oncologists’ treatment decisions for patients with ovarian cancer, this study demonstrates the power of SEngine’s functional drug sensitivity assay to identify novel therapeutic targets and drug synergies to combat hard-to-treat ovarian cancers. "We are excited to share these new findings that identified two novel BET proteins as candidate therapeutic targets for OCCC and suggest a potential drug combination therapeutic strategy for OCCC,” said Shogo Shigeta, MD, PhD, current Research Associate in the department of gynecology at the Tohoku University Graduate School of Medicine and lead author of the study. “The validation of our study with organoids derived from patient samples will help enable rapid clinical translation." “In this study, SEngine’s PARIS® Test was applied to patient derived tumor cells to identify new therapeutic strategies for hard-to-treat cancers. This is yet another example of the benefit that functional testing brings to oncologists seeking novel treatment options,” commented Carla Grandori, MD, PhD, co-founder and Chief Executive Officer of SEngine Precision Medicine. About PARIS® Test The PARIS® Test is based on the capability to propagate patient-specific cancer cells as organoids outside the body and is applicable to all solid tumors including colon, breast, lung, ovarian and pancreatic cancer. Organoids are cancer-derived cells grown in 3D outside the body, which maintain the functionality of the original tumor as well as its genomic characteristics. For cancers where a treatment path is not clear, such as many metastatic and recurrent cancers, the PARIS® Test provides crucial information to treating physicians to match the right drug to the right patient. About SEngine Precision Medicine SEngine Precision Medicine Inc. is a precision oncology company revolutionizing cancer therapies by pre-testing drugs on patient-derived organoids grown ex-vivo utilizing patient specific tumor cells. As a spin-out from the world-renowned Fred Hutchinson Cancer Research Center, SEngine is leveraging over two decades of R&D in diagnostics and drug discovery. The Company is commercializing the PARIS® Test, a next generation diagnostic test that predicts drug responses integrating knowledge of cancer genomics with organoids, robotics, and AI-driven computational tools. SEngine’s CLIA certified PARIS® Test generates predictive drug sensitivity reports for patients with solid tumors. SEngine is also pursuing drug discovery via strategic collaborations with biopharmaceutical / pharma companies leveraging its precision oncology platform. Discover more at SengineMedicine.com and follow the latest news from SEngine on Twitter at @SEngineMedicine and on LinkedIn . Contact: Stephanie Carrington stephanie.carrington@westwicke.com 646-277-1282