D1 receptor x D2 receptor x μ opioid receptor x 5-HT2 receptor

This is a single site trial in 30 patients with schizophrenia, schizoaffective, or bipolar I/II/NOS disorder in which all participants will receive eight weeks of olanzapine and samidorphan (Olz/Sam) plus four weeks of aerobic exercise.

主要研究目的：评估奥氮平萨米多芬片相比于奥氮平片对成人精神分裂症受试者体重的影响。 次要研究目的：评估奥氮平萨米多芬片相比于奥氮平片对成人精神分裂症受试者的抗精神病疗效及安全性。

The goal of this [clinical trial] is to [evaluate the safety and efficacy of olanzapine-samidorphan tablets] in [adults with schizophrenia]. The main question[s] it aims to answer are:
* [question 1] Olanzapine-samidorphan significantly mitigate weight gain better than olanzapine.
* [question 2] Olanzapine- samidorphan and olanzapine have similar antipsychotic efficacy.