A Randomized, Double-Blind, Vehicle Controlled Study To Evaluate The Safety, Tolerability, And Efficacy Of DMT210 Gel In Adult Patients With Moderate To Severe Acne Rosacea

The study evaluates the safety, tolerability, and efficacy of DMT210 Gel, 5% when applied twice daily for 12 weeks in adult patients with moderate to severe acne rosacea. Half of participants will receive DMT210 Gel while the other half will receive vehicle control.

Start Date01 Jan 2017

Sponsor / Collaborator

Dermata Therapeutics, Inc.

NCT02949960 / CompletedPhase 2

DMT210 Topical Gel in the Treatment of Mild to Moderate Atopic Dermatitis

The objective of the study is to evaluate the safety and efficacy of DMT210 Gel, 5% compared to vehicle control following 28 days of twice-daily topical application to selected target lesions in male and female patients with mild to moderate atopic dermatitis (AD).

Start Date01 Oct 2016

Sponsor / Collaborator

Dermata Therapeutics, Inc.

100 Clinical Results associated with IL-8 x TNF-α x GPCR x IL-6 x TLR2

100 Translational Medicine associated with IL-8 x TNF-α x GPCR x IL-6 x TLR2

0 Patents (Medical) associated with IL-8 x TNF-α x GPCR x IL-6 x TLR2

Literatures (Medical) associated with IL-8 x TNF-α x GPCR x IL-6 x TLR2

03 Sep 2021·Journal of Dietary Supplements

Alterations in Systemic Inflammatory Response Following a Half-Marathon Race with a Combined Curcumin and Pomegranate Supplement: A Feasibility Study

Article

Author: Tanner, Elizabeth A. ; Davis, Asheal A. ; Gary, Melody A. ; Michalik, Stephan ; McFarlin, Brian K.

Endurance running training can lead to gradual accumulation of inflammation and soreness ultimately resulting in overuse injuries. Management of soreness and inflammation with pharmaceuticals (i.e. non-prescription pain relievers) during long-term training is not a suitable solution due to known side effects (e.g. gastrointestinal complications, etc.). Dietary polyphenols (i.e. curcumin, pomegranate, etc.) have been purported to reduce inflammation and muscle soreness, without these negative side effects making them ideal for use in an exercise model. The purpose of the present feasibility study was to explore the combined effect of optimized curcumin and pomegranate extract supplementation prior to (PRE) and after (4H and 24H) an organized half-marathon race on blood inflammatory proteins and inflammation-associated RNA. Daily supplementation (1000 mg/d) started 26 days before a half-marathon which doubled on days 27-31. Data were analyzed with R software and Welch t-test, significance set at p < 0.05. At both 4H and 24H, supplementation was associated with alterations in protein (IL-10, IL-13, IL-4, ITAC, MIP-1alpha, MIP-3alpha, BDNF, sIL-2Ralpha, and TNF-alpha; p < 0.05) and RNA (CCL22, GUSB, IL-6, LINC00305, NKILA, PTGES, THRIL, TRAF6, ARG2, CD1A, CD55, CFI, CSF2, CXC3CL1, CX3CR1, EDNRB, GATA3, LILRB5, THY1, CD3D, MRC1, GPR183, HAMP, MBL2, CASP3, B2M, KLRF2, PDCD1LG2, IL-10, PTGS2, TLR2, IL-6R, IL-8, IL-7R, MASP1, MYD88, TNFRSF1B, TNFRSF1A, and TIRAP; p < 0.05) biomarkers compared to control. Pathway classification of these biomarkers indicated supplementation may be associated with a more favorable muscle recovery profile. Our findings support the notion that combined curcumin and pomegranate supplementation may represent a useful addition to a comprehensive exercise training plan.

01 May 2018·Immunology LettersQ4 · MEDICINE

Immunobiologically relevant level of aflatoxin B1 alters transcription of key functional immune genes, phagocytosis and survival of human dendritic cells

Q4 · MEDICINE

Article

Author: Abbas Bahari ; Mahmoud Mahmoudi ; Jalil Mehrzad ; Hesam Dehghani ; Mohammad Reza Bassami

The effects of naturally occurring levels of aflatoxin (AF) B₁ on the expression of key molecules and function of dendritic cells (DCs) were investigated on human monocyte-derived DCs (MDDCs) by cell culture, RT-qPCR, and flow cytometry. An environmentally relevant level of AFB₁ remarkably impaired the phagocytic capacity of MDDCs. Furthermore, AFB₁ significantly affected the transcript levels of some key functional genes in MDDCs. It caused an up-regulation of key transcripts in cytochrome P450 (CYP) family, MyD88, NF-KB, TNF-α, TLR2, TLR4, COX-2, HLA-DR, CCR7, CD209, LFA3 and CD16. AFB₁ down-regulated the expression of AhR, TGF-β, CD11c and CD64 within 2-12 h post-exposure. In contrast, the transcription of some other key genes, including IL-10, IL-1β, AKR7A2, GSTM1, IL-6. IL-8 and C5aR in post-AFB₁ treated MDDCs was only slightly changed. The results indicate that an environmentally relevant level of AFB₁ impairs the phagocytosis capacity of MDDCs and dysregulates the key functions in these pivotal immune cells. This could provide a mechanistic explanation for the observed in vivo immunotoxicity associated with this mycotoxin, and further emphasize the essential need for reduction of AFB₁ levels in agricultural commodities.

01 Jan 2018·Bratislava Medical JournalQ4 · MEDICINE

Influence of vitamin D on the expression of mRNA of cytokines in the mucosa of inflammatory bowel disease patients

Q4 · MEDICINE

Article

Author: Drahovska, H. ; Vrablicova, Z. ; Huorka, M. ; Stuchlikova, M. ; Soltys, K. ; Killinger, Z. ; Krajcovicova, A. ; Hlavaty, T. ; Koller, T. ; Payer, J. ; Stuchlik, S. ; Sturdik, I. ; Jackuliak, P.

The aim of this study was to analyze the influence of 25(OH)VD serum concentration on the expression of mRNA cytokines (IL-6, IL-8, IL-12, IL-17, IL-23, TNFα, CCR1, CCR2, CCR5, CCR9, CCL5, TLR2, TLR4, TLR5, CD207 ,CD206, FoxP3) in mucosa of IBD patients. The cohort consisted of 86 IBD patients (48 CD and 38 UC) followed at the IBD center of University Hospital Bratislava-Ruzinov. We performed colonoscopy in each patient and took biopsies from mucosa of sigma and terminal ileum. Serum concentration of 25(OH)VD was assessed at the time of colonoscopy. mRNA was extracted from mucosal biopsy samples for each cytokine. Then we analyzed the correlation between VD and the expression of mRNA of cytokines from biopsies samples. In CD we observed a significant positive correlation of serum concentration 25(OH)VD and the expression mRNA level of IL-6. There was also trend towards significant positive correlation of the expression mRNA of TNFα, IL-10, IL-23, TLR 2 in inflamed mucosa of terminal ileum as well as the expression mRNA of CCR5 and CCR1 in non-inflamed mucosa from terminal ileum. We also found a trend towards positive correlation between 25(OH)VD and the expression mRNA of IL-23, TLR4, CD 207, CCR1, CCR5 and CD 206 in non-inflamed mucosa of sigma in UC.VD significantly correlated with the levels of expression of several inflammatory cytokines including TNFα in colonic mucosa of patients with IBD (Tab. 4, Fig. 3, Ref. 31).

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