SIRT3

New business unit is focused on "undruggable" targets for age-related indications and genetically inherited diseases. MOUNT LAUREL, N.J., Sept. 20, 2023 /PRNewswire/ -- CCM Biosciences, a pharmaceutical discovery and development company that recently confirmed its launch from stealth, today announced its latest business unit — CCM Protein Upregulation — dedicated to advancing first-in-class drug leads for age-related conditions such as Alzheimer's, Parkinson's, and infertility as well as for genetically inherited diseases such as cystic fibrosis, using highly differentiated technology platforms for improving the enzymatic activity or expression level of critical proteins implicated in the pathogenesis of such disorders. Continue Reading Enhancement of the activity or expression level of proteins is important for the treatment of many age-related and genetically inherited conditions. However, whereas reduction of enzymatic activity or protein expression level can be achieved for a very broad class of protein targets by inhibitors — which comprise the vast majority of small molecule drugs — and protein degraders, respectively, enhancement of the activity or expression level of protein targets is notoriously difficult. Protein targets susceptible to enzymatic activity enhancement have historically been almost entirely restricted to those with naturally evolved, so-called allosteric binding sites, and enhancement of protein expression by orally bioavailable drug molecules generally requires interaction between the drug and the cellular machinery for protein synthesis at the genetic level. CCM Protein Upregulation's technology platform is comprised of methods for the design of drugs that can enhance enzyme activity in the absence of allosteric binding sites, as well as drugs that can enhance translation of messenger RNAs (mRNAs) for genes bearing nonsense mutations to enable efficient production of functional proteins. CCM's sirtuin-activating drug leads were discovered in-house using its proprietary, patented drug discovery platform. Tweet this Advances aimed at improving human healthspan and lifespan are arguably among the most coveted targets in healthcare but also among the most scientifically complex ones. A class of enzymes known as sirtuins has been shown to play a central role in the regulation of human longevity and age-related diseases. However, most of these enzymes are considered "undruggable" because of the challenge of improving the activity of these enzymes in the absence of known allosteric sites. Among the seven mammalian sirtuin enzymes SIRT1-7, only SIRT1 has a known allosteric site. To date, sirtuin activation has been pursued pharmaceutically for SIRT1 by allosteric activation and for other sirtuins by nutraceutical supplements that are not drugs. CCM's sirtuin-activating drug leads were discovered in-house using its proprietary, patented drug discovery platform, which combines computational biophysics and DNA-Encoded Libraries, building upon publications by CCM scientists in the Proceedings of the National Academy of Sciences, Bioorganic and Medicinal Chemistry, the Journal of Chemical Physics, and PLoS. Application of the platform led to the discovery of novel first-in-class hits for activation of SIRT3, the major sirtuin enzyme in mitochondria – the energy production powerhouses of cellular metabolism that become less efficient with age, in part due to loss of sirtuin activity. "Characterization of the novel sirtuin activators uncovered for the first time the mechanism whereby they can activate enzymes without allosteric sites. In particular, these compounds were shown to increase up to two-fold the catalytic efficiency of SIRT3 under conditions wherein the essential metabolic cofactor NAD+ is depleted, as it is in old age. Such compounds have the potential to rejuvenate the activity of SIRT3 to levels observed in youth," said Dr. Raj Chakrabarti, CEO of CCM Biosciences. Preclinical studies are underway on evaluating the efficacy of such non-allosteric sirtuin activators for conditions stemming from the decline of mitochondrial function and NAD+ levels with age, such as Parkinson's and the reduction of fertility in females of advanced maternal age. Genetically inherited diseases affect hundreds of millions of people worldwide. An estimated 30 million of those patients are impacted by a nonsense mutation, which results in making an incomplete, nonfunctional protein product. CCM Protein Upregulation's drug leads represent a first-in-class opportunity to treat multiple diseases caused by nonsense mutations. The company's drug leads for nonsense mutation translational readthrough were discovered using computer-aided drug discovery methods, and acquired through exclusive licensing rights from the University of Palermo and the Italian Cystic Fibrosis Foundation. With promising preclinical animal study results, IND-enabling studies for the lead indication of cystic fibrosis are underway. About CCM Biosciences CCM Biosciences is a biotechnology company dedicated to discovering and developing novel drugs, including small molecules, gene therapies, biologics, and nanomedicines. CCM's patented drug discovery platforms were developed at Chakrabarti Advanced Technology, a privately funded R&D institute founded in 2010 with scientists in the US, France and India and with publications in leading scientific journals including PNAS, Nucleic Acids Research, American Chemical Society journals and Nature Publishing Group journals. These platforms are complemented by the contract research, development, and manufacturing organizations (CRDMO) at PMC Group, developed through acquisitions of industry-leading companies. Contact: Anisha Ghosh Email: [email protected] SOURCE CCM Biosciences

Houston, TX, April 22, 2021 (GLOBE NEWSWIRE) -- Aging is a reality that everyone must face when its time comes. At that time, one loses most of the energy required to do even the regular activities. Aging comes with a series of problems including difficulty in climbing the stairs, wrinkled skin, and increased forgetfulness. Importantly, aging robs people of the vibe and energy they need in the bedroom. Once they experience these signs of aging, people start developing the fear of losing themselves to age. At that point, even everyday activities become too much to do and people blame their age for everything. All the same, one needs to decide whether he/she wants to live with aging or try to change it. For those who want to overcome the effects of aging, there is an amazing solution on the market known as Longevity Activator. This formula claims to help users slow down the aging process and make them feel young and vibrant at any time of the day. Some supplement niches in the alternative medicine industry are relatively new. This is certainly not the case when it comes to anti-aging solutions. For thousands of years, people have worked to find ways to help minimize the effects of aging. We should be entirely clear about one universal scientific fact before we begin our review: no supplement can keep you from aging permanently. You can delay the aging process and live for as long as possible by taking good care of your body. A consistent schedule of exercise is hard to beat, especially when you choose to pair it with a healthy diet full of fruits and vegetables. It can be hard to deal with the visual effects of aging, however. And these aging effects are the main issue that most people grapple with. The wrinkles, the loss of collagen, and other visual effects can be incredibly embarrassing. Aging processes affect everyone differently; some people experience serious aging effects at 40, while others look like they’re twenty until they reach their actual sixties! Our best recommendation involves preventative measures; keeping your skin moisturized and healthy can prevent major wrinkles from taking hold, for example. But what about people who are already feeling the effects of advanced age? There might be a possible solution in the supplement market. While modern medicine is only really a couple hundred years old, tribes and groups of people have used anti-aging remedies for thousands of years. Longevity Activator is one of the newest anti-aging supplements to hit the open market, and we’re excited to bring you a full review of everything that the formula has to offer. Robert D. is identified as one reviewer of the formula, and he says that the supplement had helped him overcome the “aches and pains” of advanced age while providing him with a higher level of energy. Today’s review is all about Longevity Activator. Dr. Ryan Shelton is apparently one of the people behind this new dietary supplement, which makes some major claims about helping people avoid the aging process for as long as possible. Read on to find out more. What is Longevity Activator? Longevity Activator is a scientifically proven dietary formula that works to reduce age-related memory loss issues and helps build stronger mental health. According to the creator, this product claims to give users the peace of mind that they deserve throughout their lives. The natural formula heals users’ DNA on a timely basis to give them long-term results. The manufacturers of the Longevity Activator believe aging symptoms occur in different ways according to the individual. The symptoms may include regular body aches, forgetfulness, fatigue, low sexual urge and drive, and unbalanced blood sugar levels. Aging may also lead to wrinkles on the skin, significant weight gain, and sore joints. According to the creators of the Longevity Activator, most of these symptoms occur due to a sedentary lifestyle that includes poor diet and lifestyle. In modern times, most people find it difficult to avoid these two things. The Longevity Activator supplement aims to tackle the effects of toxins arising from unhealthy foods. The formula reverses the user’s biological clock, gives smoother bodily functions, and restores a youthful look. Importantly, the supplement achieves its purpose naturally without involvement in strenuous workouts or bland diets. According to the creator, the Longevity Activator formula works at a cellular level where it transforms one’s DNA into a younger and healthier functioning. This process prevents one from suffering aging symptoms forever. How Does Longevity Activator Work? The Longevity Activator formula contains natural ingredients only. The manufacturers obtained the ingredients from natural sources and therefore, the supplement contains no adverse side effects. The body can absorb the ingredients easily to boost the power of the hormone telomeres. The human body contains 46 strands of DNA. These strands get weaker as one’s age advances. Naturally, the DNA strands have a cap known as a telomere, which protects and prevents them from completely wearing out. This cap is gradually sliced off in the aging process. Consequently, they lose their ability to keep one younger. The Longevity Activator formula by Zenith Labs contains natural ingredients that work to improve the strength of the telomere hormone. They ensure that the DNA doesn’t age and fade away with age. The enzyme telomerase stops the wearing out of the telomere cap and helps protect the damage of the DNA. This allows the user to remain younger even if the age advances. Once activated, the enzyme facilitates DNA growth and replication. Importantly, it protects the telomeres to keep the DNA healthy. To promote telomerase synthesis and telomeres support, one has to reduce stress and keep exercising. It’s equally important to adopt a healthy diet with low carbs. However, only these are not enough. In fact, people find it nearly impossible to completely cut off foods containing toxins from their diet. This is where Longevity Activator comes into play. This supplement embraces a blend of natural ingredients that gives it the functionality and power it delivers. It aims to give the body all the ingredients it needs to strengthen the protective layer of the DNA, preventing the body from aging. Additionally, the Longevity Activator supplement contains a mix of natural vitamins, amino acids, and other nutrients that protects the DNA cap (telomere). Users of this supplement can therefore slow down their aging process and remain younger. The idea behind the Longevity Activator is to help users keep young and youthful while extending their lifespan naturally and medically. Importantly, users can consume the supplement regularly to deliver several health benefits. Zenith Labs Longevity Activator Ingredients The Longevity Activator supplement contains two main telomere-supporting agents to ensure it delivers the best results. (SPECIAL OFFER) Click Here to Get Longevity Activator with an Exclusive Discount Price Online Telomere Agent #1 The first ingredient of the Longevity Activator supplement is 50mg of Terminalia Chebula. This helps reduce the rate of telomere shortening and cut the speed of aging by half. At the cellular level, the supplement reduces the rate at which the DNA replicates and divides. This allows the user to maintain a youthful feel and outlook. It drives away the effects of aging and gives the users the power to continue doing what they love—whether it’s writing or golfing. Telomere Agent #2 This second ingredient is derived from Purslane herbs, which help support the production and activity of the telomerase enzyme. Besides, it enhances telomere length to lower the aging rate. According to the creator, Purslane helps slow down the telomere shortening by 57 percent within two weeks of using it. Additionally, the herb has some underlying health benefits. For instance, it lowers stress levels and improves users’ cognitive abilities and memory retention. In addition to these two chief ingredients, the Longevity Activator formula contains other supportive ingredients to ensure that it achieves its purpose. Other ingredients in this formula include: Inflammation Support This set of ingredients contains the turmeric root, which is an effective pain reduction agent. Turmeric root is one of the most popular herbs for activating a healthy response to inflammation. It works better than conventional drugs such as Tylenol or Advil, which only relieve pain by soothing the nerves for a short time. Turmeric root addresses the inflammation issue from the root, which ensures the user doesn’t suffer from pain and aches again in the future. Since it’s a natural ingredient, its effects may not be as immediate as those of Advil and Tylenol. However, it delivers long-lasting results, which are not as damaging to the liver as the scientific drugs are when used for a long time. Additionally, turmeric root helps prevent indigestion by transforming white fat cells into brown body fat. This process allows the body to easily burn them. It also supports blood pressure and cholesterol levels and helps the body maintain a healthier immune system. Cardiovascular Support To support the cardiovascular system, the Longevity Activator formula includes 25mg of Resveratrol. This drug is known for its effectiveness in supporting and protecting the cardiovascular system. This ingredient is available in red wine, but one would have to take a large amount of the wine to get the levels that the body requires. Taking too much wine could expose one to the risks of alcohol poisoning. The best way to obtain Resveratrol is by consuming the Longevity Activator supplement. In addition to supporting cardiovascular functions, this ingredient supports the Sirtuins genes. These genes help repair damaged DNA and improve other functions of the boy aside from lowering the aging rate. Some of the areas it helps improve include: (HUGE SAVINGS TODAY) Click Here to Get Longevity Activator Supplement For The Lowest Price Right Now Memory Element #1 Additionally, the Longevity Activator supplement contains a couple of elements to work on the user’s memory. The first element here is the Korean Ginseng Root. This ingredient is known for its memory-boosting properties. Together with memory retention, it helps in giving the user a longer attention span, improved concentration, and lowered stress levels. Memory Element #2 Another memory element in this formula is the Cintanche Derticola herb. Alongside the Red Ginseng extract, these elements work together to give users better hormone regulation and increased libido. Heart Element Sugar Belly, which is a heart health supportive agent, represents this group of added ingredients. Besides, Sugar Belly helps balance the body’s insulin response and regulates blood sugar and cholesterol levels. This allows users to balance their body weight and blood pressure levels. Immune System Support The Longevity Activator supplement also comes with an immune system boosting ingredient. This ingredient delivers three main benefits. It supports healthy blood sugar levels, balances inflammation levels, and protects the user’s cardiovascular system. Performance Enhancement The Longevity Activator formula includes Cordyceps, which is a potential herb known for its ability in boosting physical strength and stamina, as well as recovery rates. Love Element Importantly, the supplement contains Ashwagandha root, which is known to increase nitric oxide levels in the body. This ingredient helps open the blood vessels and allows users to enjoy stronger and longer-lasting erections. The natural root also improves sex drive and stamina. Longevity Activator Benefits The Longevity Activator supplement delivers the following benefits, according to their official website: (LOWEST PRICE ONLINE) Get Longevity Activator Directly from the Official Zenith Labs Website for the Biggest Discount According to the creator of the Longevity Activator supplement, users can observe all of these benefits by using the formula for at least 60 days. Longevity Activator Drawbacks Longevity Activator Pricing Made by Zenith Labs, the Longevity Activator supplement has been much more affordable compared to other supplements of its caliber. Natural supplements involve a lot of research and trials before they can be released to the public. This process consumes a lot of time and resources. However, the manufacturers of the Longevity Activator supplement have offered good discounts on all packages today. Here are the offers: Interested users can place their orders through the official website at ? The manufacturer accepts multiple payment methods including PayPal and major credit or debit cards. Importantly, each order is backed up by a six-month moneyback guarantee. If you try the Longevity Activator supplement for 180 days and it fails to work for you, you’re free to ask for a complete refund. Longevity Activator Conclusion The manufacturer recommends taking the supplement daily with breakfast or lunch. The changes should come between seven and ten days of using the supplement consistently. However, for the best results, users should continue taking the supplement for at least 60 days. Even so, users need to remember that the Longevity Activator is just a dietary supplement and not a drug. Therefore, it should not substitute for a medication prescribed by a physician. Users with pre-existing conditions or those under prescribed medication should consult their healthcare providers before taking the supplement. The core scientific concept behind Longevity Activator is the “shoelace secret.” Time Magazine called it one of the only methods we have to potentially “turn back the clock” on the aging process. As the lead medical director for Zenith Labs, Dr. Ryan Shelton poured quite a bit of time and research into integrating this mysterious shoelace method into this new dietary supplement. Like many anti-aging supplements, Longevity Activator also makes a big deal about how the traditional medical industry is involved in a huge “cover-up” that prevents it from solving the aging problem. Stiff joints, “senior moments,” embarrassment in the bedroom, caffeine dependence, low energy, and countless other effects come from our natural aging process. You can’t really avoid the aging process itself; age comes for us all. But the available evidence makes a compelling case for Longevity Activator as a way to help address the worst effects of this process. ALSO READ: Zenith Labs Longevity Activator Customer Reviews and User Testimonials: Will It Work For Everyone? Official Website: Contact Details: Longevity Activator Email: Support@LongevityActivator.com Phone: +1 (800) 928-1184 About MarketingByKevin.com This product review is published by Marketing By Kevin. Marketing By Kevin reviews are researched and formulated by a group of experienced natural health advocates with years of dedication and determination to finding the highest quality health products and wellness programs available. It should be noted that any purchase derived from this resource is done at your own peril. It is recommended to consult with a qualified professional healthcare practitioner before making an order today if there are any additional questions or concerns. Any order finalized from this release’s links are subject to the entire terms and conditions of the official website’s offer. The researched information above does not take any direct or indirect responsibility for its accuracy. Affiliate Disclosure: The links contained in this product review may result in a small commission to Marketing By Kevin if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products. Disclaimer: Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. Product support: Support@LongevityActivator.com Media Contact: info@marketingbykevin.com Attachment

Montreal, Quebec and Watertown, Massachusetts. February 6, 2008 - MethylGene Inc. (TSX:MYG) and EnVivo Pharmaceuticals today announced that MethylGene has exercised its right to opt-out of further funding in its collaboration with EnVivo signed in February 2005. EnVivo will continue to research and develop histone deacetylase (HDAC) inhibitors for neurodegenerative disorders such as Huntington’s, Alzheimer’s and Parkinson’s diseases under license from MethylGene. A lead compound has been identified during the collaboration and designated as a clinical candidate by EnVivo. MethylGene will receive royalties on net sales of any approved product as well as a share of any sublicense income from future partnerships EnVivo may enter into with other companies for neurodegenerative programs. “The collaboration with EnVivo has been successful in leveraging our library of HDAC inhibitors beyond oncology. A lead candidate has been identified and we expect EnVivo will move this compound into clinical trials later this year. MethylGene has decided to exercise its right to opt out of the collaboration at the development stage for this non-core indication in order to strategically focus resources on our oncology development programs and other preclinical programs,” said Donald F. Corcoran, President and Chief Executive Officer of MethylGene. “We wish EnVivo well with the program and look forward to the opportunity to participate in the upside potential.” “The collaboration has been very productive and has provided us with a rich base from which we can move into several of the neurodegenerative diseases,” added Kees Been, President and Chief Executive Officer of EnVivo. “We look forward to advancing the lead compound towards clinical trials later this year. This would be the first brain-penetrant orally-available HDAC inhibitor that is being pursued for use as a cognition enhancing agent in neurodegenerative diseases with a potential for disease modification.” About MethylGene MethylGene Inc. (TSX: MYG) is a publicly-traded biopharmaceutical company focused on the discovery, development and commercialization of novel therapeutics for cancer. The Company's lead product, MGCD0103, is an oral isotype-selective HDAC inhibitor presently in multiple clinical trials for solid tumors and hematological malignancies, including Phase II monotherapy and Phase I and Phase II combination trials with Vidaza(R), Gemzar(R) and Taxotere(R). MGCD265 is an oral kinase inhibitor targeting the c-Met, Tie-2, Ron and VEGF receptor tyrosine kinases. In addition, MethylGene’s preclinical programs include: MGCD290 an HDAC inhibitor in combination with azoles for fungal infections and a sirtuins program for cancer. MethylGene's development and commercialization partners include Pharmion Corporation, Taiho Pharmaceutical and EnVivo Pharmaceuticals. Please visit our website at About EnVivo Pharmaceuticals EnVivo Pharmaceuticals (located in Watertown, MA) is a biopharmaceutical company dedicated to discovering and developing small molecule therapeutics for disorders of the central nervous system (CNS), currently focusing on Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and cognition. The Company’s lead program, a Nicotinic Acetylcholine Receptor Agonist Program for cognition disorders in Alzheimer’s disease and Schizophrenia, has completed Phase I clinical testing. The Company’s preclinical programs include a Histone Deacetylase inhibitor (HDACi) program for Huntington’s disease, a Gamma Secretase Modulator program, and a PDE10 inhibitor program. For more information about EnVivo, please visit Investor Relations Contacts: MethylGene Inc. Rhonda Chiger Rx Communications Group, LLC Phone: 917-322-2569 rchiger@rxir.com Donald F. Corcoran President & CEO MethylGene Inc. Phone: 514-337-3333 ext. 373 mctavishk@methylgene.com EnVivo Pharmaceuticals Inc. Kees Been President & CEO EnVivo Pharmaceuticals Inc. Phone: 617-225-4250 kbeen@envivopharma.com