Last update 08 May 2025

ATE1

Basic Info

Synonyms
Arginine-tRNA--protein transferase 1, Arginyl-tRNA--protein transferase 1, arginyltransferase 1
+ [2]
Introduction
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein (PubMed:34893540). This arginylation is required for degradation of the protein via the ubiquitin pathway (PubMed:34893540). Does not arginylate cysteine residues (By similarity).

Related

2
Drugs associated with ATE1
ATC-902
Target
ATE1
Mechanism
ATE1 modulators
Active Org.
Autotac Bio, Inc.Autotac Bio, Inc.
Originator Org.
Autotac Bio, Inc.Autotac Bio, Inc.
Active Indication
Zellweger Syndrome
Inactive Indication-
Drug Highest PhasePreclinical
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
ATC-401
Target
ATE1
Mechanism
ATE1 inhibitors
Active Org.
Autotac Bio, Inc.Autotac Bio, Inc.
Originator Org.
Autotac Bio, Inc.Autotac Bio, Inc.
Active Indication
Muscular Dystrophy, Duchenne
Inactive Indication-
Drug Highest PhasePreclinical
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
100 Clinical Results associated with ATE1
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100 Translational Medicine associated with ATE1
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0 Patents (Medical) associated with ATE1
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169
Literatures (Medical) associated with ATE1
07 Apr 2025Journal of Cell Biology
Arginylation of ⍺-tubulin at E77 regulates microtubule dynamics via MAP1S
02 Jan 2025SAR and QSAR in Environmental Research
Targeting human arginyltransferase and post-translational protein arginylation: a pharmacophore-based multilayer screening and molecular dynamics approach to discover novel inhibitors with therapeutic promise
01 Jan 2025microPublication biology
Erratum: Corrigendum: tRNA Arg binds in vitro TDP-43 RNA recognition motifs and ligand of Ate1 protein LIAT1.

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