Synonyms 毒蕈碱M3受体, acetylcholine receptor, muscarinic 3, cholinergic receptor muscarinic 3 + [2] |
Introduction The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. |
Mechanism M1 receptor antagonists [+1] |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. CN |
First Approval Date17 Mar 2020 |
Mechanism GR agonists [+6] |
Active Org. |
Originator Org. |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date18 Sep 2017 |
Mechanism M3 receptor antagonists [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date21 May 2015 |
Start Date01 Mar 2024 |
Sponsor / Collaborator McGill University [+1] |
Start Date01 Mar 2024 |
Sponsor / Collaborator |
Start Date29 Feb 2024 |
Sponsor / Collaborator |