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Last update 23 Jan 2025

CKAP4

Last update 23 Jan 2025

Basic Info

Synonyms

63-kDa cytoskeleton-linking membrane protein, CKAP4, CLIMP-63

+ [4]

Introduction

Mediates the anchoring of the endoplasmic reticulum to microtubules. High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.

Drugs associated with CKAP4

CKAP4 targeted aptamer(Wuhan University-)

Target

CKAP4

Mechanism

CKAP4 inhibitors

Active Org.

Wuhan University

Originator Org.

Wuhan University

Active Indication

Neoplasm Metastasis

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

SND-562

Target

CKAP4

Mechanism

CKAP4 inhibitors

Active Org.

Floratek Pharma SA [+1]

Originator Org.

Institute of Oncology Research [+1]

Active Indication

Ovarian Cancer [+4]

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Hv1Lt1

Target

CKAP4

Mechanism

CKAP4 inhibitors

Active Org.

Osaka University

Originator Org.

Osaka University

Active Indication

Pancreatic Cancer

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with CKAP4

100 Translational Medicine associated with CKAP4

0 Patents (Medical) associated with CKAP4

177

Literatures (Medical) associated with CKAP4

01 Dec 2024·Bioelectrochemistry

Disposable Zirconium trisulfide-Reduced graphene oxide modified conducting thread based electrochemical biosensor for lung cancer diagnosis

Article

Author: Shankar, Saurav ; Kumar, Suveen ; Chandra, Ramesh ; Sharma, Neera ; Kumar, Yogesh

Flexible technology in sensors have received much attention in monitoring of human health through various physiological indicators. Thus, it drawn a lot of interest in the development of flexible substrate for the diagnosis of various diseases via analysis of analytes. Present work focusses on the development of ecofriendly, portable, flexible, conducting thread (Th) and used as smart substrate for fabrication of biosensor towards ultrasensitive detection of the lung cancer biomarker (cytoskeleton-associated protein 4; CKAP4). The zirconium trisulfide-reduced graphene oxide nanocomposite and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) modified cotton thread based biosensor was fabricated via dip coating method. Next, successive immobilization of monoclonal antibodies of CKAP4 (anti-CKAP4) and bovine serum albumin (BSA) was performed via drop cast approach using fabricated electrode [nZrS₃@rGO/PEDOT:PSS/Th]. The response of fabricated electrode (BSA/anti-CKAP4/ZrS₃@rGO/PEDOT:PSS/Th) was recorded electrochemically versus CKAP4 concentration via chronoamperometry (CA). The results showed wider linear detection range of 6.25-800 pg mL^-1, excellent sensitivity of 85.2 µA[log(pg mL^-1)]^-1cm^-2 with good stability up to 42 days. The response of fabricated biosensor was supported by investigating response of CKAP4 biomarker present in patients of lung cancer (concentration as determined through enzyme-linked immunosorbent assay) and obtained results exhibited excellent correlation with that of standard samples.

01 Dec 2024·Zhongguo shi yan xue ye xue za zhi

[Expression and Prognostic Significance of B-cell Development-Related Genes in Children with Acute B Lymphoblastic Leukemia].

Article

Author: Fan, Ye ; Xia, Rui ; Zhang, Yan-Min ; Yin, Sha ; Liu, An-Sheng

OBJECTIVETo analyze the expression of B-cell development-related genes in acute B lymphoblastic leukemia (B-ALL), and to explore the relationship between B-cell development-related genes and the prognosis of B-ALL patients.METHODSThe GEO and TARGET databases were integrated to analyze the differential expression of B-cell development-related genes between the healthy persons and B-ALL patients and their differential expression in the B-ALL relapse and non-relapse groups. Cox single factor regression and Lasso regression were used to constructe a B-ALL specific prognosis model of B-cell development-related genes. The prognostic value of this model was analyzed by Cox multiple factor regression. The risk scores of different subtypes of B-ALL was analyzed. In the real world, the correlation between the prognostic model of B-cell development-related genes and clinical outcomes was verified through the transcriptome sequencing results of B-ALL patients. In addition, the correlation between this prognostic model and other B-ALL prognostic models was also analyzed. At last, Metascape was used to evaluate the pathway and function enrichment status related to the prognosis model.RESULTSThere were 1 097 genes specifically expressed in B-ALL and related to B cell development, 27 of which were up-regulated in the B-ALL relapse group, and 37 genes were down-regulated in the B-ALL relapse group. 14 genes were further selected to be included in the B-cell development-related prognosis model (CDC25B,CKAP4,DSTN,IGF2R,NDUFA4,ODC1,PAX5,SH3BP4,SLC27A5,APAF1,ARRB2,HHEX,IL13RA1,UVRAG) based on Cox single factor regression and Lasso regression. Risk scoring of patients with B-ALL based on the 14 genes prognosis model, the prognosis of 134 patients in the low-risk scoring group (score>0.11) was better than those in the patients with high-risk scores (score≤0.11). Multivariate analysis showed that the risk score of B-cell development-related genes was an independent prognostic factor. And the proportion of hyperdiploid positive children in the low-risk scoring group was significantly higher than that in the high-risk scoring group, while the proportion of TCF3/PBX1 positive children in the high-risk scoring group was significantly higher than that in the low-risk scoring group. At the same time, the real-world data showed that the prognosis of patients with B-ALL in the high-risk scoring group was worse than those of the patients with low-risk scores in Xi'an Children's Hospital. And the risk score of B-cell development-related genes in patients with B-ALL death was higher than that in patients with B-ALL non-death. In addition, there is a positive correlation between the risk score calculated by the metabolic-related gene prognostic scoring system and the risk score calculated by the B-cell developmental-related gene prognostic model. At last, differential gene enrichment analysis suggested that the prognosis risk was related to the process of embryonic development and differentiation to various systems, especially to the B cell receptor signaling pathway.CONCLUSIONThe specific expression of B-cell development-related genes in B-ALL is related to the prognosis of B-ALL. The prognosis model composed of 14 genes is expected to be a new prognostic marker for children with B-ALL.

01 Oct 2024·Vascular Medicine

RETRACTION NOTICE: Circular RNA suppression of vascular smooth muscle apoptosis through the miR-545-3p/CKAP4 axis during abdominal aortic aneurysm formation

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