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Last update 08 May 2025

STAG1

Last update 08 May 2025

Basic Info

Synonyms

Cohesin subunit SA-1, SA-1, SA1

+ [5]

Introduction

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Drugs associated with STAG1

KPT-6566

Target

PIN1 x STAG1 x STAG2

Mechanism

PIN1 inhibitors [+2]

Active Org.

Karyopharm Therapeutics, Inc.

Originator Org.

Karyopharm Therapeutics, Inc.

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

STAG1 (SyntheX)

Target

STAG1

Mechanism

STAG1 modulators

Active Org.

SyntheX, Inc.

Originator Org.

SyntheX, Inc.

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with STAG1

100 Translational Medicine associated with STAG1

0 Patents (Medical) associated with STAG1

402

Literatures (Medical) associated with STAG1

03 Mar 2025·Journal of Cell Biology

Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis

Article

Author: Hossain, M. Julius ; Brunner, Andreas ; Pflaumer, Hannah ; Beckwith, Kai S. ; Halavatyi, Aliaksandr ; Lampe, Marko ; Ellenberg, Jan ; Peters, Jan-Michael ; Morero, Natalia Rosalía ; Zhang, Wanlu

How cells establish the interphase genome organization after mitosis is incompletely understood. Using quantitative and super-resolution microscopy, we show that the transition from a Condensin to a Cohesin-based genome organization occurs dynamically over 2 h. While a significant fraction of Condensins remains chromatin-bound until early G1, Cohesin-STAG1 and its boundary factor CTCF are rapidly imported into daughter nuclei in telophase, immediately bind chromosomes as individual complexes, and are sufficient to build the first interphase TAD structures. By contrast, the more abundant Cohesin-STAG2 accumulates on chromosomes only gradually later in G1, is responsible for compaction inside TAD structures, and forms paired complexes upon completed nuclear import. Our quantitative time-resolved mapping of mitotic and interphase loop extruders in single cells reveals that the nested loop architecture formed by the sequential action of two Condensins in mitosis is seamlessly replaced by a less compact but conceptually similar hierarchically nested loop architecture driven by the sequential action of two Cohesins.

01 Feb 2025·Data in Brief

Dataset of shotgun metagenomic evaluation of Sorghum bicolor rhizosphere microbiome in soils preceded by Glycine max

Article

Author: Enagbonma, Ben Jesuorsemwen ; Babalola, Olubukola Oluranti

The dataset presents the microbial diversity, community structure, and functional potential of the rhizosphere microbiome associated with Sorghum bicolor in response to crop rotation involving a Glycine max precursor. Soil samples were collected from the rhizospheres of two Sorghum bicolor cultivars, Avenger and NS55, cultivated in soils previously used for Glycine max and cultivated in soils that have not previously been used for Glycine max cultivation, as follows: i) Sorghum bicolor Avenger (SA1, SA2, and SA3) cultivated in soils previously used for Glycine max, ii) Sorghum bicolor NS55 (SN1, SN2, and SN3) grown in soils that had been cultivated with Glycine max, iii) Sorghum bicolor Avenger (RA1, RA2, and RA3) cultivated in soils not previously used for Glycine max, iv) Sorghum bicolor NS55 (RN1, RN2, and RN3) grown in soils not previously cultivated with Glycine max. Thereafter, the shotgun sequencing was done to assess the microbial composition and functional genes from the extracted DNA. The effective metagenome after QC of the twelve samples include SA1 (99.72%), SA2 (99.50%), SA3 (99.68%), SN1 (99.75%), SN2 (99.76%), SN3 (99.70%), RA1 (99.72%), RA2 (99.77%), RN3 (99.72%), RN1 (99.67%), RN2 (99.68%), and RN3 (99.54%). Information from the metagenome sequences is accessible under the bioproject numbers PRJNA1166458 (SA1, SA2, and SA3), PRJNA1166463 (SN1, SN2, and SN3), PRJNA1166623 (RA1, RA2, and RA3), PRJNA1166627 (RN1, RN2 and RN3). Actinomycetota and Function unknown dominated the microbiomes across all cropping systems. The insights gained from this dataset hold promise for advancing sustainable agricultural practices, particularly through optimizing crop rotations, developing microbial bioinoculants, and enhancing soil health. Furthermore, the functional data and the function unknown from this dataset could enrich our understanding of microbial roles in nutrient cycling, plant growth promotion, and stress mitigation, which are critical for addressing challenges in food security and environmental sustainability.

02 Jan 2025·Angewandte Chemie International Edition

Regulating Electron‐Phonon Coupling by Solid Additive for Efficient Organic Solar Cells

Article

Author: Song, Jiali ; Hao, Xiaotao ; Li, Yun ; Hu, Haixia ; Yang, Renqiang ; Qiao, Jiawei ; Fu, Zhen ; Ge, Zhongwei ; Sun, Yanming ; Duan, Xiaopeng ; Yin, Hang

AbstractStrong electron‐phonon coupling can hinder exciton transport and induce undesirable non‐radiative recombination, resulting in a shortened exciton diffusion distance and constrained exciton dissociation in organic solar cells (OSCs). Therefore, suppressing electron‐phonon coupling is crucially important for achieveing high‐performance OSCs. Here, we employ the solid additive to regulating electron‐phonon coupling in OSCs. The planar configuration of SA1 confers a significant advantage in suppressing lattice vibrations in the active layers, reducing the scattering of excitons by phonons. Consequently, a slow but sustained hole transfer process is identified in the SA1‐assisted film, indicating an enhancement in hole transfer efficiency. Prolonged exciton diffusion length and exciton lifetime are achieved in the blend film processed with SA1, attributed to a low non‐radiative recombination rate and low energetic disorder for charge carrier transport. As a result, a high efficiency of 20 % was achieved for ternary device with a remarkable short‐circuit current. This work highlights the important role of suppressing electron‐phonon coupling in improving the photovoltaic performance of OSCs.

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STAG1

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