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Last update 08 May 2025

ATP6V0C

Last update 08 May 2025

Basic Info

Synonyms

ATP6C, ATP6L, ATP6V0C

+ [12]

Introduction

Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002, PubMed:36074901). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments, and in some cell types, it is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).

Drugs associated with ATP6V0C

Anti-VATPase nanobody(Tufts University)

Target

ATP6V0C

Mechanism

ATP6V0C blockers

Active Org.

Tufts University

Originator Org.

Tufts University

Active Indication

Breast Cancer

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with ATP6V0C

100 Translational Medicine associated with ATP6V0C

0 Patents (Medical) associated with ATP6V0C

153

Literatures (Medical) associated with ATP6V0C

07 Jan 2025·Proceedings of the National Academy of Sciences

Elucidation of a distinct photoreduction pathway in class II Arabidopsis thaliana photolyase

Article

Author: Zou, Shuhua ; Wang, Bingyao ; Kang, Xiu-Wen ; Ding, Bei ; Zhou, Zhongneng ; Tang, Siwei ; Zhou, Yalin ; Chen, Zijing ; Zhong, Dongping

Class II photolyases (PLs) are a distant subclade in the photolyase/cryptochrome superfamily, displaying a unique Trp–Tyr tetrad for photoreduction and exhibiting a lower quantum yield (QY) of DNA repair (49%) than class I photolyases (82%) [M. Zhang, L. Wang, S. Shu, A. Sancar, D. Zhong, Science354 , 209–213 (2016)]. Using layer-by-layer mutant design and femtosecond spectroscopy, we have successfully determined the rates of electron transfer and proton transfer, driving force, and reorganization energy for nine elementary steps involved in the initial photoreduction of class II Arabidopsis thaliana photolyase (AtPL), thereby constructing the photoreduction network specific to class II PLs. Several dynamic features have been revealed including a slow-rise (172 ps) and fast-decay (26 ps) kinetics between the excited lumiflavin and adenine groups within the flavin adenine dinucleotide cofactor, a slower electron transfer (ET) (22 ps) between the excited lumiflavin and the nearest Trp in the Trp triad (W a ) as compared to reported class I PL (0.8 ps), and a rapid deprotonation of the distal Trp in the Trp triad (W c ). Most strikingly, we captured a slightly energetically unfavorable ET step between W a and the center Trp (W b ), as opposed to the decreasing reduction potential observed in class I PL that drives the electron flow unidirectionally. Such an energetically uphill ET step leads to a lower photoreduction quantum yield (~34%) in class II AtPL compared to that of class I PL (~45%), raising an important question on the evolutionary implications of various photoreduction networks in photolyases and cryptochromes.

01 Oct 2024·Plant Physiology

FATTY ACID DESATURASE4 enhances plant RNA virus replication and undergoes host vacuolar ATPase-mediated degradation

Article

Author: Jia, Zhaoxing ; Chen, Jianping ; Wu, Guanwei ; Yu, Tianqi ; Fang, Xinxin ; Rui, Penghuan ; Zheng, Hongying ; Lu, Yuwen ; Wu, Jian ; Yan, Fei ; Peng, Jiejun ; Rao, Shaofei

AbstractEmerging evidence indicates that fatty acid (FA) metabolic pathways regulate host immunity to vertebrate viruses. However, information on FA signaling in plant virus infection remains elusive. In this study, we demonstrate the importance of fatty acid desaturase (FAD), an enzyme that catalyzes the rate-limiting step in the conversion of saturated FAs into unsaturated FAs, during infection by a plant RNA virus. We previously found that the rare Kua-ubiquitin-conjugating enzyme (Kua-UEV1) fusion protein FAD4 from Nicotiana benthamiana (NbFAD4) was downregulated upon turnip mosaic virus (TuMV) infection. We now demonstrate that NbFAD4 is unstable and is degraded as TuMV infection progresses. NbFAD4 is required for TuMV replication, as it interacts with TuMV replication protein 6K2 and colocalizes with viral replication complexes. Moreover, NbFAD4 overexpression dampened the accumulation of immunity-related phytohormones and FA metabolites, and its catalytic activity appears to be crucial for TuMV infection. Finally, a yeast 2-hybrid library screen identified the vacuolar H+-ATPase component ATP6V0C as involved in NbFAD4 degradation and further suppression of TuMV infection. This study reveals the intricate role of FAD4 in plant virus infection, and sheds light on a new mechanism by which a V-ATPase is involved in plant antiviral defense.

01 Sep 2024·Cortex

Functional integration and segregation during semantic cognition: Evidence across age groups

Article

Author: Wu, Wei ; Hoffman, Paul

Semantic cognition is underpinned by ventral anterior temporal lobe (vATL) which encodes knowledge representations and inferior frontal gyrus (IFG), which controls activation of knowledge based on the needs of the current context. This core semantic network has been validated in substantial empirical findings in the past. However, it remains unclear how these core semantic areas dynamically communicate with each other, and with other neural networks, to achieve successful semantic processing. Here, we investigated this question by testing functional connectivity in the core semantic network during semantic tasks and whether these connections were affected by cognitive ageing. Compared to a non-semantic task, semantic tasks increased the connectivity between left and right IFGs, indicating a bilateral semantic control system. Strengthened connectivity was also found between left IFG and left vATL, and this effect was stronger in the young group. At a whole-brain scale, IFG and vATL increased their coupling with multiple-demand regions during semantic tasks, even though these areas were deactivated relative to non-semantic tasks. This suggests that the domain-general executive network contributes to semantic processing. In contrast, IFG and vATL decreased their interaction with default mode network (DMN) areas during semantic tasks, even though these areas were positively activated by the task. This suggests that DMN areas do not contribute to all semantic tasks: their activation may sometimes reflect automatic retrieval of task-irrelevant memories and associations. Taken together, our study characterizes a dynamic connectivity mechanism supporting semantic cognition within and beyond core semantic regions.

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ATP6V0C

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