This clinical trial is looking at a drug called BT1718 in adult patients with advanced solid tumours. The main aim of the study is to find the maximum dose of BT1718 that can be given safely to patients; learn more about the potential side effects of BT1718 and how they can be treated and also what happens to BT1718 inside the body.

Start Date24 Jan 2018

Sponsor / Collaborator

Cancer Research UK

[+1]

EUCTR2016-004633-24-GB / Unknown statusPhase 1/2IIT

A Cancer Research UK Phase I/IIa trial of BT1718 (a Bicycle drug conjugate) given intravenously in patients with advanced solid tumours

Start Date18 Jan 2018

Sponsor / Collaborator

Cancer Research UK

100 Clinical Results associated with MMP14 x Tubulin

100 Translational Medicine associated with MMP14 x Tubulin

0 Patents (Medical) associated with MMP14 x Tubulin

Literatures (Medical) associated with MMP14 x Tubulin

01 Nov 2012·European Journal of Cell BiologyQ3 · BIOLOGY

ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion

Q3 · BIOLOGY

Article

Author: Philippe Chavrier ; Perrine Paul-Gilloteaux ; Antonio Castro-Castro ; Guillaume Montagnac ; Carsten Janke

Invasive tumor cells use proteases to degrade and migrate through the stromal environment consisting of a 3D network of extracellular matrix macromolecules. In particular, MT1-MMP, a membrane-anchored metalloproteinase, is critical during cancer cell invasion. MT1-MMP is stored in endosomal compartments and then delivered to invadopodia, the specialized plasma membrane domains of invasive cancer cells endowed with extracellular matrix-degradation capacity. In macrophages, traffic of MT1-MMP vesicles to invadopodia-related podosomes requires microtubules. We previously found that in breast tumor MDA-MB-231 cells an increase of microtubule and cortactin acetylation upon inhibition of HDAC6 correlates with a decrease of matrix degradation and invasion in three-dimensional collagen I gel. Here, we investigated the role of the recently identified α-tubulin N-acetyltransferase 1 ATAT1 in invasive MDA-MB-231 cells. We found that the dynamics and distribution of MT1-MMP-positive endosomes require regulation of acetylation levels. We observed that ATAT1 tubulin acetyltransferase binds and regulates cortactin acetylation levels. In addition, ATAT1 colocalizes with cortactin at the adherent surface of the cells and it is required for 2D migration and invasive migration of MDA-MB-231 cells in collagen matrix. All together, our data indicate that a balance of acetylation and deaceylation by ATAT1/HDAC6 enzymes with opposite activities regulates the migratory and invasive capacities of breast tumor cells.

01 Mar 2010·Cancer InvestigationQ4 · MEDICINE

Upregulation of SEPT7 Gene Inhibits Invasion of Human Glioma Cells

Q4 · MEDICINE

Article

Author: Xiaozhi Liu ; Peiyu Pu ; Chunsheng Kang ; Guangxiu Wang ; Zhi-Fan Jia ; Xuan Zhou ; Qiang Huang ; Peng Xu ; Song Xu

OBJECTIVESTo explore the role of SEPT7 in glioma cell invasion.METHODSSEPT7 was transfected into human glioma cell lines U251 and TJ899, the invasive abilities were evaluated by transwell assay, scratch assay, and 3-D/2-D Matrigel growth. The expression of MMP2/9, MT1-MMP, integrin alpha(v)beta(3), and TIMP1/2 was detected by immunohistochemistry, immunofluorescence, and Western blot analyses. Distribution of alpha-tubulin was examined by laser scanning confocal analysis.RESULTAfter SEPT7 trasfection, cell invasion was inhibited, expression of MMP2/9, MT1-MMP, and integrin alpha(v)beta(3) was decreased, while TIMP1/2 was increased, and alpha-tubulin was redistributed.CONCLUSIONThese results suggest that SEPT7 plays an important role in the glioma cell invasion.

01 Jan 2010·Journal of Oral Pathology & MedicineQ3 · MEDICINE

Class II β-tubulin is a novel marker for human tonsillar M cells and follicular dendritic cells

Q3 · MEDICINE

Article

Author: Seung Yeon Ha ; Ju Han Lee ; Qiang Wu ; Sun Ho Kee ; Zheng Sheng Wu ; Hyun Yee Cho ; Young Sik Kim ; Su Kang Kong ; Jongseon Choe

OBJECTIVEMembranous (M) cell of the human palatine tonsil is an antigen entry site for mucosal infection, but its location is obscure in histological sections. Recently, a microarray analysis has demonstrated that clusterin, annexin A5, CD44, MMP14, and beta-tubulin are candidate genes of M cell marker in mice. Among these genes, we here describe class II beta-tubulin as a new marker for human tonsillar M cells and follicular dendritic cells (FDCs), and present its usefulness for diagnosis of angioimmunoblastic T-cell lymphomas (AILTs).MATERIALS AND METHODSImmunohistochemistry and Western blotting for class II beta-tubulin were performed using 81 cases of lymphoid, gastrointestinal and thyroid tissues, and an FDC cell line, respectively. Double immunostaining with clusterin and class II beta-tubulin were carried out.RESULTSClass II beta-tubulin localized the M cells and FDCs in the palatine tonsils (10/10, 100%) and adenoids (10/10, 100%). It was colocalized with clusterin in the palatine tonsils. However, class II beta-tubulin staining did not identify intestinal M cells in the intestines. Immunoblot analysis revealed that class II beta-tubulin expression was upregulated in HK cells, a normal FDC cell line. Class II beta-tubulin immunostaining highlighted hyperplastic FDC meshworks in all AILTs (14/14, 100%).CONCLUSIONClass II beta-tubulin is a specific histochemical marker for human tonsillar M cells and FDCs. Thus, class II beta-tubulin immunostaining may be useful to identify tonsillar M cells and to diagnose FDC proliferative lesions such as AILT.

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