FAP x Proteasome

5 October 2023 Avacta Group plc (“Avacta” or the “Group” or the “Company”) Avacta to present promising new data from Affimer® and pre|CISIONTM platform assets at AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics AVA3996: FAP-α-activated proteasome inhibitor from pre|CISIONTM platform concentrates proteasome inhibitor payload in the tumour, increasing the therapeutic index of this class of drugs AVA032: anti-PD-L1 Affimer® fused to IL-15 demonstrates encouraging in vitro and in vivo efficacy Avacta Group plc (AIM: AVCT), a life sciences company focused on improving healthcare outcomes through targeted cancer treatments and diagnostics, today announces that it will be presenting two posters at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, taking place on 11-15 October 2023 in Boston Massachusetts. Details of the poster presentations are as follows: Abstract title: AVA3996, a novel pre|CISION™ medicine, targets a warhead to the tumor microenvironment via Fibroblast Activation Protein (“FAP”) mediated cleavage to elicit tumor cell kill Poster number: C169Session: Poster Session C Session date and time: Saturday, October 14 | 12:30 pm-4:00 pmSession location: Level 2, Exhibit Hall D Abstract title: A novel, tumor-targeted immunocytokine comprising an anti-PD-L1 Affimer® fused to IL-15 exhibits potent anti-tumor activity Poster number: A077Session: Poster Session A Session date and time: Thursday, October 12 | 12:30 pm-4:00 pmSession location: Level 2, Exhibit Hall D Dr Fiona McLaughlin, Chief Scientific Officer of Avacta commented:“We look forward to presenting the promising new data from Avacta’s Therapeutics platform assets at this conference. As disclosed in the Company’s announcement on 19 September 2023, our lead asset AVA6000 continues to advance through the clinic at pace. We are simultaneously conducting IND-enabling studies for promising assets derived from the pre|CISIONTM and Affimer® platforms. The data to be presented showcases the potential of our two therapeutic platforms to generate further high value clinical assets. “AVA3996, a FAP-α-activated proteasome inhibitor based on our pre|CISIONTM technology, demonstrates targeted killing of cancer cells in vitro and, by concentrating the active warhead in the tumour, reduces systemic toxicity associated with this class of drug. “AVA032, our anti-PD-L1 Affimer® fused to the pro-inflammatory cytokine interleukin 15 (IL-15) displays encouraging efficacy when tested in multiple models of immunomodulation, stimulating a potent immune response and reversing the immunosuppressive tumour microenvironment.” Further information regarding the conference can be found on the ACCR’s website here: https://www.aacr.org/meeting/aacr-nci-eortc-international-conference-on-molecular-targets-and-cancer-therapeutics-2/ The posters will be available to view following the conference here: https://avacta.com/about/scientific-resources/ -Ends- For further information from Avacta Group plc, please contact: Avacta Group plcAlastair Smith, Chief Executive OfficerTony Gardiner, Chief Financial OfficerMichael Vinegrad, Group Communications DirectorTel: +44 (0) 1904 21 7070www.avacta.comStifel Nicolaus Europe Limited (Nomad and Broker)Nicholas Moore / Nick Adams / Samira Essebiyea / Nick Harland / William Palmer-BrownTel: +44 (0) 207 710 7600www.stifel.comPeel Hunt (Broker)James Steel / Chris Golden / Patrick BirkholmTel: +44 (0) 207 418 8900www.peelhunt.com ICR Consilium (Media and IR)Mary-Jane Elliott / Jessica Hodgson / Sukaina Virjiavacta@consilium-comms.com About Avacta Group plc - https://www.avacta.com Avacta Group is a UK-based company focused on improving healthcare outcomes through targeted cancer treatments and diagnostics. Avacta has two divisions: an oncology biotech division harnessing proprietary therapeutic platforms to develop novel, highly targeted cancer drugs, and a diagnostics division, which is executing on an M&A led growth strategy to create a full-spectrum diagnostics business focused on supporting healthcare professionals and broadening access to testing. Avacta’s two proprietary platforms, Affimer® and pre|CISION™ underpin its cancer therapeutics whilst the diagnostics division leverages the Affimer® platform to drive competitive advantage in its markets. The pre|CISION™ platform modifies chemotherapy to be activated only in the tumour tissue, reducing systemic exposure and toxicity. This is achieved by harnessing an enzyme called FAP which is highly upregulated in most solid tumours compared with healthy tissues, turning chemotherapy into a “precision medicine”. The lead pre|CISION™ programme, AVA6000 a tumour activated form of doxorubicin, is in Phase 1 studies and has shown dramatic improvement in safety compared with standard doxorubicin, and early signs of clinical activity. Affimer® is a novel biologic platform which has significant technical and commercial advantages compared with antibodies and is used both to develop advanced immunotherapies and to improve the performance of immunodiagnostics. With a balanced business and capital allocation model: a high-value oncology pipeline supported by a revenue generating, fast-growing diagnostics business, Avacta seeks to create long-term shareholder value alongside patient benefit. To register for news alerts by email go to https://avacta.com/investors/investor-news-email-alerts/ About AVA3996 AVA3996 is a FAP-α-activated proteasome inhibitor, based on the Company’s pre|CISIONTM technology platform. AVA3996 has the potential to become a targeted cancer treatment for various indications, overcoming cytotoxicity issues displayed when the free, non-targeted form of proteasome inhibitor is systemically administered to patients. About AVA032 AVA032 is an anti-PD-L1 Affimer® fused to the cytokine interleukin 15 (“IL-15”). It carries improved properties compared to monoclonal antibodies, currently used as cancer therapeutics, and works to reverse the immunosuppressive tumour micro-environment, inducing a lasting immune response aimed at stimulating a patient’s immune system to destroy cancer cells.

LONDON & WETHERBY, England--(BUSINESS WIRE)-- Avacta Group plc, a life sciences company developing innovative, targeted oncology drugs and powerful diagnostics, announces it will present a poster entitled ‘AVA3996, a novel pre|CISION™ medicine, targeted to the tumor microenvironment via Fibroblast Activation Protein-alpha (FAP-a) mediated cleavage’, at the American Association for Cancer Research (AACR) 2023 Annual Meeting, taking place at Orange County Convention Center, Orlando, Florida on 16 April. The poster describes the data and pre-clinical rationale for the further development and disease positioning of the Company’s second pre|CISION™ candidate, AVA3996, a tumour microenvironment activated proteasome inhibitor. AVA3996 utilises Avacta’s pre|CISION™ platform to improve the therapeutic index and therefore utility of proteasome inhibitors in tumours with high FAP levels, including both solid and haematological tumours. AVA3996 has the potential to deliver efficacious levels of the proteasome inhibitor warhead directly to the tumour microenvironment while reducing systemic exposure and hence associated toxicities, such as peripheral neuropathy. Attending the conference from Avacta will be Fiona McLaughlin – Chief Scientific Officer, Neil Bell – Chief Development Officer, David Jones – VP Biology and Francis Wilson – VP Chemistry. Poster Presentation Title AVA3996, a novel pre|CISION™ medicine, targeted to the tumor microenvironment via fibroblast activation protein-alpha (FAP-a) mediated cleavage Session Category Experimental and Molecular Therapeutics Session Title Targeting the Tumour Microenvironment Session Date and Time April 16, 2023 1:30 PM – 5:30 PM ET Location Orange County Convention Center, Section 20 Poster Board Number 17 Abstract Presentation Number 583 The abstract is available via the AACR annual meeting website, here: Copies of the poster will be available on Avacta’s website following the conference at: Alastair Smith, Avacta Chief Executive Officer, will provide a video presentation overview for investors examining the data presented in the poster. This will be available on 17th April at