Last update 01 Nov 2024

IGFBP5

Last update 01 Nov 2024

Basic Info

Synonyms

IBP-5, IBP5, IGF-binding protein 5

+ [5]

Introduction

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Drugs associated with IGFBP5

US20230192827

Patent Mining

Target

IGFBP5

Mechanism-

Active Org.

Enthera SrlStartup

Originator Org.

Enthera SrlStartup

Active Indication

Immune System Diseases

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

OGX-225

Target

IGFBP2 x IGFBP5

Mechanism

IGFBP2 inhibitors [+1]

Active Org.-

Originator Org.

Ionis Pharmaceuticals, Inc.

Active Indication-

Inactive Indication

Breast Cancer

Drug Highest PhaseDiscontinued

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

OGX-133

Target

IGFBP5

Mechanism

IGFBP5 inhibitors

Active Org.-

Originator Org.

OncoGenex Technologies, Inc.

Active Indication-

Inactive Indication

Prostatic Cancer

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with IGFBP5

100 Translational Medicine associated with IGFBP5

0 Patents (Medical) associated with IGFBP5

1,536

Literatures (Medical) associated with IGFBP5

01 Dec 2024·Molecular Biology Reports

Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5 in diabetic cataract

Article

Author: Wang, Xiaolei ; Zang, Xinyi ; Xie, Jin ; Chen, Peng ; Mao, Shilan ; Dai, Yunhai ; Liu, Wenhui ; Cao, Rui

BACKGROUNDCataract contributes to visual impairment worldwide, and diabetes mellitus accelerates the formation and progression of cataract. Here we found that the expression level of miR-204-5p was diminished in the lens epithelium with anterior lens capsule of cataract patients compared to normal donors, and decreased more obviously in those of diabetic cataract (DC) patients. However, the contribution and mechanism of miR-204-5p during DC development remain elusive.METHODS AND RESULTThe mitochondrial membrane potential (MMP) was reduced in the lens epithelium with anterior lens capsule of DC patients and the H2O2-induced human lens epithelial cell (HLEC) cataract model, suggesting impaired mitochondrial functional capacity. Consistently, miR-204-5p knockdown by the specific inhibitor also attenuated the MMP in HLECs. Using bioinformatics and a luciferase assay, further by immunofluorescence staining and Western blot, we identified IGFBP5, an insulin-like growth factor binding protein, as a direct target of miR-204-5p in HLECs. IGFBP5 expression was upregulated in the lens epithelium with anterior lens capsule of DC patients and in the HLEC cataract model, and IGFBP5 knockdown could reverse the mitochondrial dysfunction in the HLEC cataract model.CONCLUSIONSOur results demonstrate that miR-204-5p maintains mitochondrial functional integrity through repressing IGFBP5, and reveal IGFBP5 may be a new therapeutic target and prognostic factor for DC.

01 Dec 2024·Molecular Biology Reports

High-intensity interval training enhances mRNA expression of IGF1Ea in rat Achilles tendon

Article

Author: Tsuchiya, Yoshifumi ; Takakura, Hisashi ; Osawa, Seita ; Izawa, Tetsuya

High-intensity interval training (HIIT) reportedly enhances the functional properties of the musculoskeletal system. However, the effects of HIIT on tendons remain unclear. Sixteen male rats were randomly assigned to the control (Con) or HIIT group (n = 8 in each group). Rats in the HIIT group executed the HIIT program consisting of 2.5 min treadmill running and 4.5 min rests between the bouts, 5 days per week for 9 weeks. Running speed, number of sets, and inclination were incrementally increased during the training period. Histological analysis revealed no apparent morphological changes in the extracellular matrix structure or nuclei of tenocytes between the groups. Real-time reverse transcription polymerase chain reaction analysis revealed that Igf1Ea mRNA expression was enhanced in the HIIT group. Furthermore, Igfbp5 mRNA expression tended to be higher in the HIIT group. The 9-week HIIT program enhanced tenogenic Igf1Ea mRNA expression.

01 Nov 2024·Breast Cancer Research and Treatment

A novel role of IGFBP5 in the migration, invasion and spheroids formation induced by IGF-I and insulin in MCF-7 breast cancer cells

Article

Author: Torres-Alamilla, Pablo ; Cortes-Reynosa, Pedro ; Rodríguez-Rojas, Karem ; Salazar, Eduardo Perez ; Rodríguez-Ochoa, Nínive

AbstractPurposeThe insulin-like growth factor (IGF) system includes IGF-I, IGF-II insulin and their membrane receptors. IGF system also includes a family of proteins namely insulin-like growth factor-binding proteins (IGFBPs) composed for six major members (IGFBP-1 to IGFBP6), which capture, transport and prolonging half-life of IGFs. However, it has been described that IGFBPs can also have other functions.MethodsIGFBP5 expression was inhibited by shRNAs, migration was analyzed by scratch-wound assays, invasion assays were performed by the Boyden chamber method, spheroids formation assays were performed on ultra-low attachment surfaces, expression and phosphorylation of proteins were analyzed by Western blot.ResultsIGFBP5 is a repressor of IGF-IR expression, but it is not a repressor of IR in MCF-7 breast cancer cells. In addition, IGFBP5 is a suppressor of migration and MMP-9 secretion induced by IGF-I and insulin, but it does not regulate invasion in MCF-7 cells. IGFBP5 also is a repressor of MCF-7 spheroids formation. However treatment with 340 nM rescues the inhibitory effect of IGFBP in the MCF-7 spheroids formation.ConclusionIGFBP5 regulates IGF-IR expression, migration and MMP-9 secretion induced by IGF-I and/or insulin, and the spheroids formation in MCF-7 breast cancer cells.

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IGFBP5

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