Last update 01 Nov 2024

ITGA2&ITGB1

Last update 01 Nov 2024

Basic Info

Synonyms

整合素α2β1, very late antigen 2, VLA-2

Introduction-

Drugs associated with ITGA2&ITGB1

BTT-3033

Target

ITGA2&ITGB1

Mechanism

ITGA2&ITGB1 antagonists

Active Org.

Biotie Therapies Oy

Originator Org.

Biotie Therapies Oy

Active Indication-

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

68Ga-IABtP

Target

ITGA2&ITGB1

Mechanism

ITGA2&ITGB1 antagonists

Active Org.

Shanghai Jiao Tong University

Originator Org.

Shanghai Jiao Tong University

Active Indication

Prostatic Cancer

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

BTT-3034

Target

ITGA2&ITGB1

Mechanism

ITGA2&ITGB1 antagonists

Active Org.

Biotie Therapies Oy

Originator Org.

Biotie Therapies Oy

Active Indication-

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with ITGA2&ITGB1

100 Translational Medicine associated with ITGA2&ITGB1

0 Patents (Medical) associated with ITGA2&ITGB1

311

Literatures (Medical) associated with ITGA2&ITGB1

01 Dec 2022·Cellular Oncology

ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation

Article

Author: Wu, Heshui ; Wen, Shuang ; Meng, Junpeng ; Sun, Yan ; Ren, Dianyun ; Cai, Hongkun

PURPOSEIntegrin alpha 2 (ITGA2, also known as CD49b or VLA-2) is the alpha subunit of a transmembrane receptor for collagens and related proteins. Previously, we found that ITGA2 may regulate immune cell infiltration in pancreatic cancer by inducing PD-L1 expression. As yet, however, whether ITGA2 regulates immune cell infiltration in pancreatic cancer by other mechanisms remains unclear.METHODSRNA sequencing was performed to identify differentially expressed genes in ITGA2-silenced pancreatic cancer cells. Protein-protein interactions were detected via co-immunoprecipitation. The infiltration level of immune cells was assessed using an immunofluorescence staining assay.RESULTSWe found that ITGA2 can activate the cytosolic DNA-sensing pathway and promote STING expression in pancreatic cancer cells. In addition, we found that ITGA2 induces DNMT1 degradation by disrupting the interaction between DNMT1 and Kindlin2 in pancreatic cancer cells. As a DNA methyltransferase, we found that DNMT1 overexpression induced by ITGA2 silencing significantly up-regulated the methylation level of the STING gene promoter. Finally, ITGA2 silencing combined with DNMT1 inhibitor treatment induced immune cell infiltration in pancreatic cancer.CONCLUSIONOur data indicate that ITGA2 induces STING expression by interacting with DNMT1 and inducing the degradation of DNMT1. ITGA2 silencing combined with DNMT1 inhibitor treatment may be a novel therapeutic strategy for pancreatic cancer.

09 Jun 2022·NatureQ1 · CROSS-FIELD

Binarity of a protostar affects the evolution of the disk and planets

Q1 · CROSS-FIELD

Article

Author: Haugbølle, Troels ; Harsono, Daniel ; Kristensen, Lars E ; Jørgensen, Jes K ; Bergin, Edwin A ; Kuruwita, Rajika L

Nearly half of all stars similar to our Sun are in binary or multiple systems¹, which may affect the evolution of the stars and their protoplanetary disks during their earliest stages. NGC 1333-IRAS2A is a young, Class 0, low-mass protostellar system located in the Perseus molecular cloud². It is known to drive two bipolar outflows that are almost perpendicular to each other on the sky^3,4 and is resolved into binary components, VLA1 and VLA2, through long wavelength continuum observations⁵. Here we report spatially and spectrally resolved observations of a range of molecular species. We compare these to detailed magnetohydrodynamic simulations: the comparisons show that inhomogeneous accretion onto the circumstellar disks occurs in episodic bursts, driving a wobbling jet. We conclude that binarity and multiplicity in general strongly affect the properties of the emerging stars, as well as the physical and chemical structures of the protoplanetary disks and therefore potentially any emerging planetary systems.

21 Jan 2022·Investigative Opthalmology & Visual ScienceQ2 · MEDICINE

Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction

Q2 · MEDICINE

ArticleOA

Author: Xing, Yue ; Li, Xueke ; Ma, Jin ; Shen, Huangxuan ; Liu, Xin ; Liu, Xiaoxue ; Zeng, Lingyan

PurposeErianin has been reported to inhibit tumor activity by suppressing the expression of integrins. It is hypothesized that erianin can inhibit retinal neovascularization in collagen by suppressing the expression of integrins. With an aim to test this hypothesis, the regulation of erianin on collagen-mediated retinal angiogenesis via the Ras homolog gene family member A (RhoA)/Rho-associated coiled-coil containing protein kinase 1 (ROCK1) signaling pathway induced by α2 and β1 integrin-collagen interactions was investigated.MethodsThe effects of erianin on human retinal vascular endothelial cells (HRVECs) were assessed in vitro using a hypoxia model in a three-dimensional cell culture induced by cobalt (II) chloride (CoCl2). A hypoxia-induced retinopathy model in adult zebrafish and zebrafish embryos was established to assess the antiangiogenic effect of erianin with and without vitreous collagen in vivo. The expression of α2 and β1 integrin and RhoA/ROCK1 pathway in HRVECs and zebrafish retinas were analyzed.ResultsIn vitro, collagen improved the angiogenic potential of HRVECs, including migration, adhesion, and tube formation, in a three-dimensional cell culture model. Erianin suppressed the angiogenic processes of the CoCl2-induced hypoxia HRVEC model in a concentration-dependent manner. In vivo, erianin reduced retinal angiogenesis in the hypoxia-induced retinopathy model in adult and embryo zebrafish. Erianin inhibited the expression of α2 and β1 integrin and RhoA/ROCK1 in a hypoxia-induced model in vitro in three-dimensional cell culture and in vivo in adult zebrafish.ConclusionsCollagen-mediated retinal angiogenesis may be regulated by erianin via the RhoA/ROCK1 signaling pathway induced by α2 and β1 integrin-collagen interactions. These findings suggest that erianin has the therapeutic potential on intraocular collagen-mediated retinal angiogenesis.

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ITGA2&ITGB1

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