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Unprecedented comprehension of the interaction between Spike and the Human Estrogen Receptor Alfa provides insights for a new generation of anti SARS-CoV-2 and pan-Coronavirus vaccines Italian and US researchers have revealed how the SARS-CoV-2 Spike protein interacts with human Estrogen Receptor-α (ERα) leading to severe coagulopathy observed in COVID-19 patients. The new data - published in Nature’s Signal Transduction and Targeted Therapy - shows that point mutations in the sequence of SARS-CoV-2 Spike (S)-protein eliminate its pro-coagulation effect without compromising immunogenicity. The findings provide actionable insights for designing vaccines lacking of estrogen-receptor mediated side effects for all coronavirus strains and other viral infections. MILAN & SAN MATEO, Calif.--(BUSINESS WIRE)-- Dompé farmaceutici announced today new peer-reviewed data demonstrating that small changes in the SARS-CoV-2 Spike (S)-protein sequence can eliminate its effect in inducing coagulation1. The tendency for the Spike protein to stimulate inflammatory and coagulation has been implicated in coagulopathy observed in the lungs, heart and kidneys of COVID-19 patients with a similar and extremely rare effects observed in a minority of patients who received COVID-19 vaccines. This press release features multimedia. View the full release here: Framework Dompé farmaceutici Biotech production (Photo: Business Wire) Data stemmed from the EXSCALATE supercomputing calculation predicted a potential function of Spike (S) as a co-factor for human ERα nuclear signalling. This interaction is mediated by a nuclear receptor co-regulator (NRC) LXD-like motif present on the viral protein S2 subunit, and the activation function 2 (AF-2) region on ERα2. This work builds on other recent studies3,4 showing that coagulopathy is clearly associated with the interaction of the SARS-CoV-2 Spike (S) protein with the human Erα. While circulating estrogens play a protective role by regulating the immune response to infection, modulation of ERα signalling in SARS-CoV-2-infected lung tissue stimulates proinflammatory signals leading to hypertrophy, vasoconstriction, and vessel obstruction. In the new article the scientists of the italo-american collaboration (encompassing Centro Cardiologico Monzino in Italy and the National Institute on Drug Abuse and the Johns Hopkins School of Medicine in the US) demonstrated that the interaction between the Spike protein and ERα leads to an increase in tissue factor (TF) and the overall pro-coagulation activity in two human endothelial cell lines. The results were further validated by overexpressing S-protein in mice. This pro-coagulative function of Spike in vitro and in vivo, was abolished or strongly reduced by the variants of the Spike proteins carrying mutations in the interaction domain with ERα (as predicted by EXSCALATE). “The value and benefits of vaccines in countering the COVID-19 pandemic remain unquestionable and overwhelming compared to the risks associated with infection from SARS-CoV-2” underscores Maurizio Pesce, a research Group Leader at the Monzino Cardiology Center in Milan, Italy, and initiator of the study in 2021 together with the leading Silvia Barbieri, another research Group Leader at Monzino, “We hope that our findings will be considered in the development of the next generation of vaccines reducing the residual side effects and risks. Our data also unravel a new function of the viral protein in direct regulation of thrombosis associated factors. This has general implications not only for COVID-19, but for other viral infections altering the coagulation pro patients”. “This continuing research is critical to understand the pathogenetic mechanisms associated with SARS-CoV2 infection and causal mechanisms of some rare COVID-19 vaccine side effects,” says Dompé farmaceutici Chief Scientific Officer Marcello Allegretti “Ongoing expanding data is revealing a well-conserved region with the same characteristics of the LXD-like motif present on the viral protein S2 subunit, also in other Coronaviruses. This evidence could open new scenarios in ‘pan-Coronavirus’ vaccination. We are excited to identify a path toward further refinement strategies to enable even more powerful benefits through future vaccination and booster initiatives”. ____________________________________________________________________________________ About Dompé Dompé is a private, rapidly scaling international biopharmaceutical company founded in Milan, Italy, with a 130-year legacy of medical innovation. The R&D department of the company is anchored by EXSCALATE, a structure-based virtual screening platform developed in-house that leverages one of the most powerful supercomputing and artificial intelligence platforms in the world. Today, Dompé employs more than 800 employees worldwide and maintains a US commercial operations hub in the San Francisco Bay Area as well as an R&D presence in Boston. Forward Looking Statements This press release refers to certain information that may not coincide with expected future results. Dompé firmly believes in the soundness and reasonableness of the concepts expressed. However, some of the information is subject to a certain degree of indetermination in relation to its research and development activities and the necessary verifications to be performed by regulatory bodies. Therefore, as of today, Dompé cannot guarantee that the expected results will be consistent with the information provided above. 1. SS Barbieri et al. Relevance of the viral Spike protein/cellular Estrogen Receptor-α interaction for endothelial-based coagulopathy induced by SARS-CoV-2 - Signal Transduction and Targeted Therapy - 2. Allegretti, M. et al. Repurposing the estrogen receptor modulator raloxifene to treat SARS-CoV-2 370 infection. Cell Death Differ. 29, 156-166 (2022). 371 - 3. Wilcox et al. Sex Differences in Thrombosis and Mortality in Patients Hospitalized for COVID-19, Am J Cardiol. 2022 May 1; 170: 112–117 - 4. Science Advances - The SARS-CoV-2 spike protein binds and modulates estrogen receptors - eadd4150 (2022) 30 November 2022 -

Saint-Herblain (France), March 2, 2023 – Valneva SE (Nasdaq: VALN; Euronext Paris: VLA), a specialty vaccine company, today announced additional data from remaining clinical studies and an update on regulatory submissions for its inactivated COVID-19 vaccine, VLA2001. As previously announced, Valneva will not invest in further development of the vaccine, in the absence of a new partnership1. It is, however, completing remaining clinical studies and submissions as agreed with regulators. On February 23, 2023, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued a positive opinion for the use of VLA2001 in adults 18 to 50 years of age as a booster dose to be given at least seven months following primary vaccination (the second dose) with VLA2001 (homologous booster dose) or with an adenoviral vector COVID-19 vaccine (heterologous booster dose). Valneva also provided an update on its pivotal Phase 3 Study COV-Compare (VLA2001-301). In this study, neutralizing antibodies on Day 208 (six months after the second dose of the primary vaccination with VLA2001) were non-inferior compared to the active comparator AZD1222, an adenoviral vector vaccine. The fold decline of neutralizing antibodies over six months after a second vaccination with VLA2001 was similar to the active comparator, and less pronounced than for other licensed COVID-19 vaccines2,3. The T-cell response against the spike protein elicited upon vaccination with VLA2001 was in the same range as for the active comparator. Moreover, T-cell reactivity against the nucleocapsid and membrane protein was induced upon vaccination with VLA2001. Additionally, results from VLA2001-304, a Phase 3 study in older adults, 56 years of age and above, showed that VLA2001 was well tolerated by these participants when administered as a two-dose or three-dose immunization, thus confirming the previously reported favorable safety profile of VLA20014. In this age group, a two-dose vaccination with VLA2001 was inferior in terms of geometric mean titers and seroconversion rates compared to younger adults aged 30 years and above. After two doses, immunogenicity in older adults was at a level which could be correlated with 60-70% vaccine efficacy against ancestral SARS-CoV-25. A third dose of VLA2001 further increased immunogenicity in participants aged 56 years and above to the titers associated with vaccine efficacy of >90% against ancestral SARS-CoV-26,7. Finally, VLA2001’s shelf life was recently extended to 21 months compared to 18 months previously. The Company will continue to submit data to further extend it. About VLA2001VLA2001 is produced on Valneva’s established Vero-cell platform, leveraging the manufacturing technology for Valneva’s licensed Japanese encephalitis vaccine, IXIARO®. VLA2001 consists of inactivated whole virus particles of SARS-CoV-2 with high S-protein density, in combination with two adjuvants, alum and CpG 1018. This adjuvant combination has consistently induced higher antibody levels in preclinical experiments than alum-only formulations and shown a shift of the immune response towards Th1. CpG 1018 adjuvant, supplied by Dynavax Technologies Corporation (Nasdaq: DVAX), is a component of the US FDA- and EMA-approved HEPLISAV-B® vaccine. VLA2001’s manufacturing process, which was upscaled to final industrial scale, includes chemical inactivation to preserve the native structure of the S-protein. VLA2001 is expected to conform with standard cold chain requirements (2 to 8 degrees Celsius). VLA2001 was the first COVID-19 vaccine to receive a standard marketing authorization in Europe8 and the only whole virus, inactivated, COVID-19 vaccine to receive marketing authorization in Europe for use as primary vaccination in people from 18 to 50 years of age. The vaccine was also granted conditional marketing authorization in the United Kingdom9 and emergency use authorization in the United Arab Emirates10 and Kingdom of Bahrain11. Valneva signed agreements to supply VLA2001 to certain EU Member States and the Kingdom of Bahrain12. In August 2022, the World Health Organization (WHO) issued recommendations for use of VLA200113. In light of current order levels and existing inventories, Valneva has suspended manufacturing of the vaccine and is continuing discussions on the potential sale of some of the remaining inventory. VLA2001 currently has a 21-month shelf life and the Company will continue to submit data to further extend it. About Valneva SEValneva is a specialty vaccine company focused on the development, manufacturing and commercialization of prophylactic vaccines for infectious diseases with significant unmet medical need. The Company takes a highly specialized and targeted approach to vaccine development and then applies its deep understanding of vaccine science to develop prophylactic vaccines addressing these diseases. Valneva has leveraged its expertise and capabilities both to commercialize three vaccines and to rapidly advance a broad range of vaccine candidates into and through the clinic, including candidates against the chikungunya virus and Lyme disease. Valneva Investor and Media ContactsLaetitia Bachelot-FontaineVP Global Communications & European Investor RelationsM +33 (0)6 4516 7099laetitia.bachelot-fontaine@valneva.com Joshua Drumm, Ph.D.VP Global Investor RelationsM +001 917 815 4520joshua.drumm@valneva.com Forward-Looking Statements This press release contains certain forward-looking statements relating to the business of Valneva, including with respect to the progress, timing, results and completion of research, development and clinical trials for product candidates, to regulatory approval of product candidates and review of existing products. In addition, even if the actual results or development of Valneva are consistent with the forward-looking statements contained in this press release, those results or developments of Valneva may not be sustained in the future. In some cases, you can identify forward-looking statements by words such as “could,” “should,” “may,” “expects,” “anticipates,” “believes,” “intends,” “estimates,” “aims,” “targets,” or similar words. These forward-looking statements are based largely on the current expectations of Valneva as of the date of this press release and are subject to a number of known and unknown risks and uncertainties and other factors that may cause actual results, performance or achievements to be materially different from any future results, performance or achievement expressed or implied by these forward-looking statements. In particular, the expectations of Valneva could be affected by, among other things, uncertainties and delays involved in the development and manufacture of vaccines, unexpected clinical trial results, unexpected regulatory actions or delays, competition in general, currency fluctuations, the impact of the global and European credit crisis, and the ability to obtain or maintain patent or other proprietary intellectual property protection. Success in preclinical studies or earlier clinical trials may not be indicative of results in future clinical trials. In light of these risks and uncertainties, there can be no assurance that the forward-looking statements made during this presentation will in fact be realized. Valneva is providing the information in these materials as of this press release and disclaim any intention or obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise. 1 Valneva Reports H1 2022 Results and Provides Corporate Updates - Valneva2 Pajon R et al. N Engl J Med 2022; 386:1088-10913 Zeng G et al. Lancet Infect Dis. 2022 Apr;22(4):483-4954 Valneva Reports Positive Phase 3 Results for Inactivated, Adjuvanted Covid-19 Vaccine Candidate VLA2001 (October 18, 20215 Valneva Reports Further Positive Phase 3 Immunogenicity and the First Heterologous Booster Results for its Inactivated, Adjuvanted COVID-19 Vaccine VLA2001 (August 29, 2022)6 S. Feng et al., Nature Medicine 10.1038/s41591-021-01540-1 (2021)7P. B. Gilbert et al., Science 10.1126/science.abm3425 (2021) 8 Valneva Receives Marketing Authorization in Europe for Inactivated Whole-Virus COVID-19 Vaccine VLA20019 Valneva Receives Conditional Marketing Authorization from UK MHRA for its Inactivated COVID-19 Vaccine10 Valneva Receives Emergency Use Authorization from the United Arab Emirates for its Inactivated COVID-19 Vaccine11 Valneva Receives Emergency Use Authorization from Bahrain for its Inactivated COVID-19 Vaccine VLA200112 Valneva Signs Advance Purchase Agreement with Bahrain for Inactivated COVID-19 Vaccine VLA200113 Valneva Confirms WHO Recommendations for its Inactivated COVID-19 Vaccine Attachment 2023_02_03_VLA2001_Update_PR_EN_Final

-- China commercial launch in multiple provinces and municipalities expected to begin in Q1 2023, and Clover anticipates a significant and sustained long-term annual booster market for its premium, broadly protective protein-based COVID-19 vaccines in China -- -- SCB-2019 (CpG 1018/Alum) anticipated to receive emergency use authorization (EUA) in at least one additional country and to complete multiple EUA submissions during H1 2023, with commercial value driven via bilateral supply agreements expected beginning in 2023 -- -- Expansion of Clover’s mid- to late-stage pipeline expected starting in H1 2023, with a focus on (1) building a leading respiratory vaccine franchise and (2) establishing a presence in the pediatric vaccine market in China and the Asia Pacific -- SHANGHAI, China, Jan. 15, 2023 (GLOBE NEWSWIRE) -- Clover Biopharmaceuticals, Ltd. (Clover; HKEX: 02197), a global commercial-stage biotechnology company committed to unleashing the power of innovative vaccines to save lives and improve health around the world, today provided updates on the commercialization of SCB-2019 (CpG 1018/Alum) in China and strategic priorities in 2023. “Clover transformed into a commercial-stage, vaccines-focused biotech company with proven R&D capabilities in 2022. In 2023, we are focused on launching our vaccine in multiple countries and working with health authorities in China and globally to increase booster coverage for vulnerable populations,” said Joshua Liang, Chief Executive Officer and Executive Director of Clover. “We are also planning to expand our mid- to late-stage vaccine pipeline for near-term value creation by leveraging our established vaccine development and proven cross-border collaboration capabilities.” “Clover is well positioned to make a significant impact on the COVID-19 response with our premium and broadly protective protein-based vaccine, both in China and globally, where the need to boost protection will likely provide attractive and unique opportunities for us in 2023 and beyond,” said Dr. Nicholas Jackson, President of Global Research and Development of Clover. “In addition, we are excited to share our development plans to build a leading respiratory vaccine franchise and establish a presence in the pediatric vaccine market in China and the Asia Pacific, which will further strengthen Clover’s competitive advantages and contribution to global health.” COVID-19 Vaccine Commercialization Updates China Commercialization: The commercial launch for SCB-2019 in China in multiple provinces and municipalities is expected to begin in Q1 2023. Given the scale and impact of the ongoing COVID-19 outbreaks across China, Clover now anticipates a significant and sustained long-term annual booster market opportunity in China for Clover’s premium and broadly protective COVID-19 vaccine. Recent Milestones: In early December 2022, SCB-2019 was included for emergency use authorization (EUA) in China. Subsequently, the China National Health Commission formally announced its national immunization plan for a fourth dose booster campaign and recommended prioritizing specified vaccines that demonstrate broad neutralization against Omicron, including SCB-2019, for use. Additionally, the price setting process for SCB-2019 commercialized via national procurement was completed with the China National Healthcare Security Administration. Commercial Launch Expected to Begin in Q1 2023: Clover has started commercial launch preparation activities in multiple key provinces and municipalities, based on Clover’s evaluation of market dynamics (including factors such as strategic fit, population size and competitive environment). To date, Clover has received robust interest and demand based on the premium product profile of SCB-2019 and expects the commercial launch in these strategically prioritized areas to begin in Q1 2023. Further expansion to additional provinces and municipalities is anticipated to occur throughout 2023, based on production capacity and market dynamics. Impact of Ongoing COVID-19 Outbreaks: Near Term – Wider Window to Supply to Market: As COVID-19 continues to spread rapidly across China, the number of previously infected people is expected to increase significantly through the first half of 2023. Immunity induced by prior natural infection has been observed to wane rapidly1, especially against Omicron2, leading countries around the world to recommend booster vaccination at an interval range of one to six months after infection3. While Clover’s initial commercial launch in China starting in Q1 2023 will likely be primarily comprised of boosting infection-naïve individuals, Clover expects booster vaccination of previously infected individuals to begin in Q2 2023 and to increase in proportion through the remainder of the year. Thus, Clover anticipates a more sustained, rather than short-term, rollout of booster vaccinations throughout 2023, giving Clover a wider window of time to ramp up production and maximize the impact of its premium COVID-19 vaccine.Longer Term – Sustained & Robust Annual Booster Market: With the Chinese population’s recent increasing awareness of the potential disease severity and impact of COVID-19, Clover believes that the level of certainty and the potential size of the future annual booster market for COVID-19 vaccines have increased significantly. Beyond the current National Procurement phase of COVID-19 vaccine rollout, Clover anticipates that a robust annual booster market for COVID-19 vaccines in a private market setting could emerge—similar to the growing seasonal influenza vaccination market—favoring premium products such as Clover’s adjuvanted protein-based COVID-19 vaccines and introducing attractive product pricing dynamics. Global (Ex-China) Commercialization: Clover expects SCB-2019 to receive an EUA in at least one additional country and to complete multiple EUA submissions during H1 2023, potentially driving revenue via bilateral deals starting in 2023. Bilateral EUA Submissions and Procurement Deals: Clover is now prioritizing global (ex-China) regulatory submissions directly in select countries, primarily in Asia Pacific and Latin America, based on the potential to generate significant near-term revenue and impact via bilateral supply agreements. In addition to submitting multiple EUA applications and receiving at least one EUA for SCB-2019, Clover also expects to establish at least one bilateral supply agreement in H1 2023, which could begin to drive commercial value in 2023. Other Regulatory Submissions: Although the near-term commercial opportunity derived from regulatory approvals of SCB-2019 with the European Medicines Agency (EMA) and the World Health Organization (WHO) is expected to be limited compared to bilateral deals, Clover plans to complete these regulatory submissions in 2023. EMA authorization and WHO Emergency Use Listing could continue to strengthen the value of SCB-2019 in the global market and validate Clover’s global development capabilities. Commercial Manufacturing Plan: Clover’s good manufacturing practice (GMP)-certified manufacturing facilities have the potential capacity to meet demand for SCB-2019 across multiple markets. Stockpiled inventory of key raw materials to-date enables Clover to potentially produce and release over 100 million doses of SCB-2019 in 2023. Two GMP-Certified Commercial Facilities: Clover has the unique capability to commercially produce and supply SCB-2019 at two commercial manufacturing sites that have both passed inspections and achieved GMP-compliant status: Clover’s in-house manufacturing facility in Changxing, Zhejiang Province (China GMP) and a contract development and manufacturing organization facility (European Union GMP). Capacity to Produce Hundreds of Millions of Doses: Across both manufacturing sites, Clover has the potential capacity to produce and supply hundreds of millions of doses annually. In 2022, Clover successfully completed a strategic procurement and stockpiling campaign for key raw material inventory to support the potential production and release of over 100 million doses of SCB-2019 in 2023. R&D Pipeline Updates & Plans Mid- to Late-Stage Pipeline Expansion: Clover plans to expand its mid- to late-stage pipeline (Phase 2, Phase 3, Commercial) beginning in H1 2023, with a focus on (1) building a leading respiratory vaccine franchise and (2) establishing a presence in the pediatric vaccine market in the China and Asia Pacific region. Clover is currently pursuing multiple business development opportunities in these areas. At Least One In-Licensing Deal in H1 2023: At least one mid- to late-stage vaccine in-licensing deal announcement is expected in H1 2023. Potentially differentiated (first/best-in-class) assets that could generate near-term catalysts and value creation are being prioritized. Following deal execution, Clover plans to utilize its proven R&D capabilities to achieve near-term catalysts that can continue to drive value. Building a Leading Respiratory Vaccine Franchise: The expected seasonal nature of respiratory virus outbreaks creates a potential market opportunity for co-promoting and co-administering multiple respiratory vaccines. Seizing longer-term lifecycle management opportunities to develop co-formulated product(s) could further benefit Clover and people seeking to protect themselves and their families from multiple seasonal diseases. In pursuing these varied value-creation opportunities, Clover will leverage its synergistic capabilities in R&D, manufacturing, and commercialization to potentially be a leading company in respiratory vaccines. Prioritized areas include respiratory syncytial virus (RSV) and seasonal influenza. Establishing a Presence in the Pediatric Vaccine Market: The pediatric vaccine market in China is stable and commercially attractive. Clover believes that having a presence in the pediatric market creates a potential cross-selling opportunity, not only within pediatrics but also across generations, such that older adults could be offered respiratory virus vaccines when bringing children and grandchildren to be vaccinated. Enterovirus A71 (EV71), the leading pathogenic cause of severe cases and deaths due to Hand, Foot and Mouth disease in children, and DTaP (diphtheria, tetanus, and pertussis) are two prioritized areas of interest for Clover. COVID-19 R&D Pipeline: SCB-2019: Concurrent with its commercial launch in China, Clover plans to conduct real-world effectiveness studies, with data potentially available in H2 2023. These studies could provide valuable insight into the prevention of severe disease, hospitalization and death due to COVID-19 caused by newly circulating Omicron variants in at-risk populations, and this data has the potential to strengthen SCB-2019’s commercial value and competitive positioning. Multivalent SARS-CoV-2 Vaccine Candidate: Clover is conducting research to develop a multivalent SARS-CoV-2 vaccine leveraging the Trimer-TagTM technology platform and designed to be broadly protective against currently circulating and potential future strains of the virus. Clinical development is planned to begin in 2023, with immunological bridging to SCB-2019 planned to support potential regulatory approvals. SCB-2020S COVID-19 Vaccine Candidate (chimeric beta and original strain): SCB-2020S is a second generation and potentially broadly protective COVID-19 vaccine candidate that is being evaluated with CAS-1, Clover’s in-house adjuvant system. In an ongoing Phase 1 study in South Africa, initial immunogenicity results indicated a robust immune response and broad neutralization against multiple Omicron strains elicited by SCB-2020S (CAS-1) that were in line with data for SCB-2019. A favorable safety and tolerability profile for SCB-2020S and CAS-1 was also observed. The results demonstrated clinical proof-of-concept for (1) antigen strain-change utilizing the Trimer-TagTM technology platform and (2) the immunogenicity and safety of Clover’s in-house CAS-1 adjuvant. Clover expects the study data to support the further development of Clover’s planned multivalent SARS-CoV-2 vaccine candidate, as well as the planned use of CAS-1 adjuvant in other new vaccines internally and via partnerships. Corporate & Financial Updates Cash Position: As of December 31, 2022, Clover’s unaudited cash and cash equivalents was approximately US$270 million (RMB 1.9 billion), supporting and positioning the company for success beyond 2023. Clover has already stockpiled key raw materials (supporting potential production of over 100 million doses of SCB-2019) and expects to begin converting its inventory into revenue and cash with the commercial launch in Q1 2023. R&D and G&A Expenditures in 2023: Clover expects both R&D and G&A expenditures in 2023 to decrease significantly compared to 2022 and 2021, as the late-stage clinical development for SCB-2019 (including multiple global Phase 2/3 clinical trials) has been substantially completed, and the company continues to streamline corporate operations. About SCB-2019 (CpG 1018/Alum) Clover developed the SCB-2019 antigen, a stabilized trimeric form of the S-protein based on the original strain of the SARS-CoV-2 virus, and combined it with Dynavax’s (Nasdaq: DVAX) CpG 1018 advanced adjuvant and aluminum hydroxide (alum). Phase 2/3 data from 30,000+ participants across five countries showed that SCB-2019 (CpG 1018/Alum) achieved 100% efficacy against severe COVID-19 and hospitalization caused by all strains of SARS-CoV-2 circulating during the trial, and a potentially best-in-field safety profile. Clover is developing SCB-2019 (CpG 1018/Alum) as a universal booster candidate for potential use regardless of previous vaccination technology or infection history. To date, these trials have shown that SCB-2019 (CpG 1018/Alum) elicited a robust neutralization of variants including Omicron. In December 2022, SCB-2019 (CpG 1018/Alum) was included for emergency use authorization in the People’s Republic of China and included in the National Health Commission’s fourth dose booster implementation plan. About Clover BiopharmaceuticalsClover Biopharmaceuticals is a global commercial-stage biotechnology company committed to unleashing the power of innovative vaccines to save lives and improve health around the world. With integrated research and development, manufacturing and commercial capabilities as well as strong partnerships with organizations globally, Clover has a diverse pipeline of candidates that have the potential to meaningfully reduce the burden of vaccine-preventable diseases—and to make more diseases preventable. For more information, please visit Clover's website: www.cloverbiopharma.com and follow the company on LinkedIn and Twitter. Clover Forward-looking StatementsThis press release contains certain forward-looking statements and information relating to us and our subsidiaries that are based on the beliefs of our management as well as assumptions made by and information currently available to our management. When used, the words "aim," "anticipate," "believe," "could," "estimate," "expect," "going forward," "intend," "may," "might," "ought to," "plan," "potential," "predict," "project," "seek," "should," "will," "would" and the negative of these words and other similar expressions, as they relate to us or our management, are intended to identify forward-looking statements. Forward-looking statements are based on our current expectations and assumptions regarding our business, the economy and other future conditions. We give no assurance that these expectations and assumptions will prove to have been correct. Because forward-looking statements relate to the future, they are participant to inherent uncertainties, risks and changes in circumstances that are difficult to predict. Our results may differ materially from those contemplated by the forward-looking statements. They are neither statements of historical fact nor guarantees or assurances of future performance. We caution you therefore against placing undue reliance on any of these forward-looking statements. Any forward-looking statement made by us in this document speaks only as of the date on which it is made. Factors or events that could cause our actual results to differ may emerge from time to time, and it is not possible for us to predict all of them. Participant to the requirements of applicable laws, rules and regulations, we undertake no obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. All forward-looking statements contained in this document are qualified by reference to this cautionary statement. Clover Biopharmaceuticals:Albert LiaoExecutive Director, Corporate Communicationsmedia@cloverbiopharma.com Elaine QiuDirector, Investor Relationsinvestors@cloverbiopharma.com ________________________________________ 1 Milne G, Hames T, Scotton C et al. (2021). Does infection with or vaccination against SARS-CoV-2 lead to lasting immunity? Lancet Respir Med. Dec9(12):1450-1466. 2 Nguyen, D., Lamothe, P., Woodruff, M. et al. (2022). COVID-19 and plasma cells: Is there long-lived protection? Immunological Reviews.Jul8(309)1:40-63.3 US: https://www.cdc.gov/vaccines/covid-19/clinical-considerations/interim-considerations-us.html#infection, Canada: https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-4-active-vaccines/page-26-covid-19-vaccine.html#a6.2, UK: https://www.gov.uk/government/publications/covid-19-the-green-book-chapter-14a, Australia: https://www.health.gov.au/our-work/covid-19-vaccines/advice-for-providers/clinical-guidance/clinical-recommendations, Israel: https://corona.health.gov.il/en/vaccine-for-covid/over-12/, South Africa: https://globalenvironmentandtechnology.app.box.com/s/nn930h2cpff35uooq7sdd12mhxepssn2/file/1063790237613, WHO: https://www.who.int/news-room/questions-and-answers/item/coronavirus-disease-(covid-19)-vaccines