Last update 19 Sep 2024

TK2

Basic Info

Synonyms
2'-deoxyuridine kinase TK2, Deoxycytidine kinase TK2, Mt-TK
+ [4]
Introduction
Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix (PubMed:9989599, PubMed:11687801). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK (PubMed:9989599). Widely used as target of antiviral and chemotherapeutic agents (PubMed:9989599).

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