CD43

Kling reports on advancing pipeline of therapeutic antibodies targeting novel antigens discovered with its best-in-class B-cell screening platform, Kling-Select Progress on in vitro and in vivo validation of two highly specific tumor antigens is reported: CD43s, a sialylated-glyco epitope, and U5snRNP200, an ectopically expressed antigen highly specific for AML blast Lead program KBA1412 is advancing in a Phase 1 clinical study, targeting advanced solid malignant tumors AMSTERDAM, Feb. 22, 2024 /PRNewswire/ -- Kling Biotherapeutics ("Kling" or "the Company"), a clinical stage biotech company developing antibody-based drugs against targets identified from its primary B-cell screening platform, today announces that it will be presenting findings demonstrating the power of its clinically validated, best-in-class, B cell screening platforms, Kling-Select and Kling-Evolve, at the ESMO Targeted Anticancer Therapies Congress, in Paris, France on 26 February. Michael Koslowski, Chief Executive Officer at Kling Bio, said: "Our findings consistently highlight and validate our world class, proprietary primary B cell screening platform and its ability to efficiently identify novel therapeutic targets and antibodies. Our aim is to maximise disease fighting antibodies and find a cure for all patients battling illnesses which include cancer and infectious diseases. Our lead clinical candidate KBA1412, a unique and previously undiscovered epitope of CD9, is advancing in a Phase 1 study, demonstrating a clean and safe profile in patients with advanced solid tumors. We look forward to sharing data in the foreseeable future and exploring the therapeutic potential of snRNP200 and our uniquely identified CD43 glycoform." Poster one, entitled " KBA1413, an antibody derived from a cured AML patient, recognizes a unique CD43 glycoform shared by AML, MDS and solid cancer cells," details the identification of KBA1413, a fully human antibody screened from a single acute myeloid leukemia (AML) patient who remains in long term remission following allogeneic hematopoietic stem cell transplantation. The antibody identified using Kling's proprietary B cell screening platform, Kling-Select, recognised a unique, previously undescribed, sialylated epitope on CD43 that is reactive to freshly isolated blasts of over 60 randomly selected AML and myelodysplastic syndrome (MDS) patients. It also recognised CD43 on several solid tumor indications, including melanoma and breast cancer. KBA1413 triggered TR NK-mediated antibody dependent cell-mediated cytotoxicity (ADCC) against AML cells both in vitro and in vivo, suggesting that the antibody played a role in the graft versus leukemia response of the original donor patient. KBA1413 was made into a bispecific T-cell engaging antibody (bTCE), to increase its therapeutic potential and induced potent cytotoxicity in vitro and in vivo on cell lines in primary AML. Data demonstrates that KBA1413 warrants further development as a potent and promising treatment candidate for AML, MDS and solid tumors. Poster two, entitled " snRNP200 reactive antibodies isolated from multiple AML patients show promise for targeted therapy," details how Kling's proprietary Kling-Select platform has the ability to identify new therapeutic target-antibody pairs to improve patient outcomes by interrogating the B cell repertoire of patients that have achieved remission via a strong tumor-directed immune response. The Kling-Select platform was used to discover and characterise anti-snRNP200 antibodies from three AML patients that have achieved complete response after allogeneic stem cell transplantation, establishing that anti-snRNP200 specifically and selectively bind to AML cell lines that display snRNP200 on the outer cell surface. These findings have been independently confirmed[2] and show that snRNP200 surface expression is limited to malignant cells and not expressed on normal hematopoietic stem cell progenitors. Kling will further explore the therapeutic potential of anti-snRNP200 with affinity matured variants produced with Kling-Evolve. A first-in-human, Phase 1 clinical trial on Kling's first-in-class anti-CD9 antibody in patients with advanced solid malignant tumors is ongoing and can be found on under the identifier NCT05501821. All accepted abstracts will be published online only in the ESMO TAT 2024 Abstract Book, a supplement to the ESMO journal, ESMO open. Details of the conference and poster presentations are as follow: Poster Title: KBA1413, an antibody derived from a cured AML patient, recognizes a unique CD43 glycoform shared by AML, MDS and solid cancer cells Authors: V. Clerico Mosina, M. Kedde, B. Pieters, B. Monica, K. Maijoor, R. Schotte, A. Bakker, M. Koslowski, S. Gullà[1] Date and Time: 26 February, 17:15-18:15 CET Session: Cocktail and Poster Display Session Location: Hall Bordeaux Presentation Number: 11P Poster Title: snRNP200 reactive antibodies isolated from multiple AML patients show promise for targeted therapy Authors: S. Baumann, M. Kedde, B. Monica, K. Maijoor, R. Schotte, A. Bakker, J. M. Koslowski, S. Gullà[1] Date and Time: 26 February, 17:15-18:15 CET Session: Cocktail and Poster Display Session Location: Hall Bordeaux Presentation Number: 11P 1. Kling Biotherapeutics, Amsterdam, Netherlands 2. National Library of Medicine. About Kling Biotherapeutics Kling Biotherapeutics is a clinical-stage, privately held biotech company focused on discovery and development of antibody based therapeutics. The company is headquartered in Amsterdam, Netherlands with a fully owned IP portfolio that covers platform technologies Kling-Select and Kling-Evolve for the simultaneous discovery of novel targets and identification of fully human antibodies directly from patient-derived B cells. Kling-Select relies on a fully-owned and clinically-validated B cell immortalization and screening technology to identify novel therapeutic targets and antibody binders from patients with exceptional clinical responses. This technology has successfully identified novel neutralising antibodies for various infectious diseases such as RSV (nirsevimab/Beyfortus), Covid, and Influenza. More recently, Kling-Select has been applied to peripheral and tumor-infiltrating B cells derived from cancer patients and produced a portfolio of novel and selective target-antibody pairs. The unbiased nature of this discovery platform allows identification of novel targets and unique epitopes inaccessible to traditional target discovery approaches. Kling-Evolve enables the ex vivo affinity maturation of B cell clones against targets of interest. This powerful technology can be used for the rapid evolution of neutralizing antibodies against emerging viral variants or for affinity and selectivity improvement of oncology assets. Kling Biotherapeutics is progressing a unique pipeline of oncology programs with KBA1412, a first-in-class CD9 antibody, being tested in a Phase 1 clinical trial. Details of the trial can be found on clinicaltrials.gov under identifier NCT05501821. About ESMO ESMO's core mission is to improve the quality of cancer care, from prevention and diagnosis all the way to palliative care and patient follow-up. It is to educate – doctors, cancer patients and the general public – on the best practices and latest advances in oncology. And it is to promote equal access to optimal cancer care for all patients. SOURCE Kling Biotherapeutics

Dr. Geoff Nichol, M.B., Ch.B., M.B.A., joins HaemaLogiX's Board of Directors as Non-Executive Director, bringing nearly 30 years of global drug development experience Past achievements include approval of Augmentin BID for adults and children, plus foundational clinical development of breakthrough cancer immunotherapy checkpoint inhibitors, Yervoy and Optivo SYDNEY, July 7, 2022 /PRNewswire/ -- HaemaLogiX Ltd, a clinical stage immuno-oncology biotech developing novel immunotherapies for patients with blood cancers, is pleased to announce the appointment of Dr. Geoff Nichol to its Board as Non-Executive Director. Bryce Carmine, HaemaLogiX's Chairman and CEO commented: "Geoff's impressive, globally recognised background in drug development, and in particular, in antibody development, makes him a valuable contribution to the HaemaLogiX board. Importantly, during his time at Medarex, Geoff oversaw the preclinical and clinical development of KappaMab, our multiple myeloma drug candidate. He brings outstanding industry knowledge and a highly translatable skillset to our Board mix. "We are delighted to welcome Geoff and look forward to his contributions as we continue to advance our immunotherapeutic pipeline." Dr. Nichol brings nearly 30 years' experience in drug development. His first drug development success was at SmithKline Beecham with the approval of Augmentin BID in 1996 for adults and children for all indications. As a VP at Novartis (1996-2002), he managed, successively, a clinical development therapeutic area, US Medical Affairs, and Global Project and Portfolio Management, with significant involvement in the Foradil and Xolair programs. Dr. Nichol was SVP of Development at Medarex Inc, where he was responsible for the foundational clinical development of the breakthrough cancer immunotherapy checkpoint inhibitors Yervoy (Phase 1 through Phase 3) and Opdivo (Phase 1). Medarex was acquired by Bristol Myers Squibb (BMS) in 2009 and gained regulatory approval and commercial release of both these drugs. In recognition of the significance of these breakthrough therapies in 2018 the medical scientists who discovered these checkpoint drugs – Prof James Allison and Prof Tasuku Honjo - were awarded the Nobel Prize for Physiology or Medicine. From 2011-2016 Dr. Nichol was EVP R&D at Sangamo BioSciences, a genome editing and gene therapy company. He managed the pre-clinical development of several IND candidates both in vivo and ex vivo in T cells and stem cells, and a gene therapy for haemophilia, all now in late-stage clinical trials. In 2016, Dr. Nichol became Chief Medical Officer at BioMarin Pharmaceutical Inc, managing an active portfolio of clinical development programs, including the development and approval of Brineura for Batten disease, Palynziq for Phenylketonuria a VOXZOGO for achondroplasia, and phase 3 development of BMN 270, a leading investigational gene therapy for haemophilia. In 2021, Dr. Nichol transitioned from CMO into a Senior Advisor role with BioMarin and remained active with the company until mid-2022. Dr. Nichol graduated in medicine from the Otago University Medical School in New Zealand and completed clinical advanced training in Thoracic Medicine in Christchurch New Zealand, Adelaide SA and London UK. He has an MBA from Warwick University, UK. He is a Fellow of the Royal Australasian College of Physicians. He resides is in the Bay area of San Francisco, USA. "I am delighted to be joining the Board to guide strategy around the further development of KappaMab as well as HaemaLogiX's other pipeline assets," said incoming Non-Executive Director, Dr. Nichol. "I look forward to working with the team to bring forward much needed new therapies for patients with multiple myeloma and other diseases." For more information, please contact: Investors and partners: Bryce Carmine, Chairman and CEO HaemaLogiX Ltd +61 481 344 140 [email protected] Media: Jane Lowe, Managing Director IR Department +61 411 117 774 [email protected] About HaemaLogiX Ltd | Founded in 2014, HaemaLogiX Ltd is a clinical stage immune-oncology biotech developing novel immunotherapies for patients with blood cancers. The Company is focused on the development and commercialisation of monoclonal antibodies (Mab) for the treatment of multiple myeloma and potentially other blood cancers. We have identified and characterised two novel drug targets, Kappa Myeloma Antigen (KMA) and Lambda Myeloma Antigen (LMA), on the surface of human blood cancers and autoimmune cells. These targets are highly specific to the cancer cells identified in blood cancers such as multiple myeloma, some lymphomas and Waldenstrom's macroglobulinemia. Importantly, KMA and LMA are not present on healthy cells. Clinical studies to date, have demonstrated fewer side effects, especially when compared to other current therapies in multiple myeloma. It is anticipated that further clinical studies will support this observation. HaemaLogiX is a public unlisted Australian company, and our Mab technology is based on 10 years of research conducted at the University of Technology, Sydney, along with various world-leading institutions in Australia, Europe and the US. We hold a breadth of patents and have exclusivity over both the targets and the antibodies directed to them, making our intellectual property position comparatively more valuable and less prone to competitive challenge. The monoclonal antibodies under development have also been formulated into other platforms such as CAR-T cell therapy and a bispecific monoclonal antibody. These three formulations may enable use in additional disease areas and the treatment of both early and late-stage disease giving them wide market potential. SOURCE HaemaLogiX Ltd