Placebo-Controlled, Investigator Blinded, Explorative Trial to Evaluate the Anti-inflammatory Effect of Multiple Topical Applications of R115866 Gel (0.35%) in Two Models of Cutaneous Inflammation in Healthy Male Subjects

The purpose of this exploratory trial is to assess the anti-inflammatory effect(s) of topical R115866 in a model of UVB-induced inflammation and in a model of cutaneous irritation.

Start Date01 Nov 2006

Sponsor / Collaborator

Stiefel Laboratories, Inc.

NCT00716144

/ CompletedPhase 2

A Randomized, Evaluator-Blind, Placebo-Controlled, Parallel-Group Dose-Ranging Study of the Safety and Efficacy of Oral R115866 and R115866 Placebo in the Treatment of Plaque Psoriasis

Eligible subjects will be randomly assigned to one of three dose regimens of oral R115866 or placebo for the treatment of severe plaque psoriasis for 12 twelve weeks. The safety and efficacy of R115866 will be evaluated during the treatment period and the 8-week post treatment follow-up period.

Start Date01 Jun 2006

Sponsor / Collaborator

Stiefel Laboratories, Inc.

[+1]

EUCTR2005-004623-19-GB

/ Not yet recruitingPhase 2

A Randomized, Evaluator-Blind, Placebo-Controlled, Parallel-Group Dose-Ranging Exploratory Study of the Safety and Efficacy of Oral R115866 vs. R115866 Placebo in the Treatment of Plaque Psoriasis - Oral R115866 psoriasis dose ranging study

Start Date13 Mar 2006

Sponsor / Collaborator

Barrier Therapeutics, Inc.

100 Clinical Results associated with CYP26

100 Translational Medicine associated with CYP26

0 Patents (Medical) associated with CYP26

825

Literatures (Medical) associated with CYP26

01 Dec 2025·Functional & Integrative Genomics

Transcriptome analysis of the hypothalamus and testes in Brandt’s Vole: new insights into mechanisms of photoperiodic plasticity in postnatal testicular development

Article

Author: Liu, Xiao-Hui ; Ying, Yaqi ; Zhao, Lijuan ; Li, Ning ; Wang, Lewen ; Song, Ying ; Wang, Dawei ; Wang, Zhenlong ; Sun, Hong

Postnatal gonadal development is regulated by photoperiod via the hypothalamus, especially in seasonal breeding small rodents. However, the precise molecular mechanisms remain unclear. In this study, we conducted a comparative analysis of the transcriptomes of the hypothalamus and testes in 10-week-old male Brandt's voles born under long (LP, 16L:8D) and short photoperiod (SP, 8L:16D) conditions. Results indicate that the SP group exhibited significantly smaller testes with spermatogenesis halted before meiosis, identifying 129 differentially expressed genes (DEGs) in the hypothalamus and 21,673 DEGs in the testes. In the hypothalamus, genes involved in the thyroid hormone and retinoic acid (RA) pathway were notably altered under SP conditions, including decreased Tshb and Cga expression, increased Dio3, and reduced Crabp1 and Lrat, highlighting their key roles in SP signaling. In the testes, downregulated genes were significantly enriched in male reproduction-related GO terms and metabolic KEGG pathways, such as steroid hormone biosynthesis and retinol metabolism. Key genes for testosterone synthesis (e.g. Star, Cyp11a1) and RA synthesis (e.g. Rdh10, Rdh11) were downregulated, while those linked to RA degradation (Cyp26b1) and undifferentiated spermatogonia maintenance (e.g. Gdnf, Gfra1) were upregulated. These findings outline a molecular microenvironment that favors the preservation of undifferentiated spermatogonia over their differentiation from the hypothalamus to the testes. This study firstly provides valuable insights into the transcriptomic basis of SP-inhibited testicular development in Brandt's voles.

01 May 2025·Clinical Genetics

Unexpected High Prevalence of Focal Facial Dermal Dysplasia (FFDD) Type IV Is Linked to a Founder Effect in the Belgian Population

Article

Author: Dimitrov, Boyan ; Goeteyn, Marleen ; Symoens, Sofie ; Devriendt, Koen ; Keymolen, Kathelijn ; Rosseel, Toon ; Janssens, Sandra ; Guerreiro Santano Ramos Da Silva, Marta ; Kooy, R. Frank ; Callewaert, Bert ; De Meulemeester, Sofie ; Beyens, Aude ; Hes, Frederik Jan ; Van De Voorde, Stefanie

Focal facial dermal dysplasia (FFDD) type IV is a rare inherited facial defect caused by biallelic variants in CYP26C1. This study reports two novel Belgian FFDD type IV cases, both homozygous for a recurrent CYP26C1 frameshift variant, with a common 700 kb haplotype, indicating a founder effect.

01 May 2025·Food and Chemical Toxicology

Emerging mycotoxin moniliformin induces renal tubular necrosis after oral exposure in mice

Article

Author: Ebizuka, Yuri ; Tang, Qian ; Kigata, Tetsuhito ; Yoshinari, Tomoya ; Yamagata, Hiroshi ; Yoshida, Toshinori ; Kobayashi, Mio ; Zou, Xinyu ; Shibutani, Makoto ; Ojiro, Ryota

Toxicological information on moniliformin (MON), an emerging mycotoxin, is limited. This study examined the acute and 28-day toxicity of orally administered MON in male ICR mice. Regarding the acute toxicity, among single oral doses of 0, 20, 40, and 80 mg/kg body weight (BW), MON caused proximal tubular necrosis in the kidneys at ≥ 40 mg/kg BW, and the lethal dose 50 value was estimated as 68.1 mg/kg BW. Regarding the 28-day toxicity, among oral doses of 0, 10, 20, and 40 mg/kg BW/day, MON increased absolute heart weight at 40 mg/kg BW, but histopathological changes were not evident in the heart. In contrast, 40 mg/kg BW MON induced centrilobular liver cell hypertrophy accompanied by increased absolute liver weight. Moreover, MON dose-dependently increased the absolute kidney weight at ≥ 20 mg/kg BW and increased the incidence of renal tubular regeneration at 40 mg/kg BW. RNA sequencing analysis in the renal cortex after a single dose of 40 mg/kg BW MON revealed upregulation of metabolic response-related genes, such as Cyp3a13, Cyp26b1, and Cyp4f15, and oxidative stress-related Gpx7. These results suggest that MON targets the kidneys in mice. Orally ingested MON may be metabolized in the kidneys as well as in the liver, and active intermediates or reactive oxygen species may induce renal tubular toxicity, causing proximal tubular necrosis. Based on kidney changes, the no-observed-adverse-effect-level of MON in the 28-day oral toxicity study of male mice was determined to be 10 mg/kg BW/day.

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