Perseus Therapeutics Develops TSLP Antibody for Hair Loss Prevention in Cancer Patients and Inflammatory Disease Treatment with Renowned CRO Partner

7 June 2024
Perseus Therapeutics, a pioneering biopharmaceutical company headquartered in New York City, has announced the creation of a groundbreaking thymic stromal lymphopoietin (TSLP) antibody. This antibody has the potential to prevent hair loss in cancer patients and treat various inflammatory conditions, such as asthma.

TSLP antibodies have recently garnered significant interest within the medical and pharmaceutical sectors. These antibodies are being recognized for their potential to address a variety of inflammatory and allergic diseases, based on promising efficacy data and the pressing medical needs they aim to meet.

Various companies and research entities are actively investigating TSLP antibodies. Key developments in this area include:

- AstraZeneca and Amgen have introduced Tezepelumab, the first anti-TSLP monoclonal antibody approved for treating severe asthma.
- Johnson & Johnson has acquired Proteologix, gaining access to its bispecific antibody that targets TSLP and IL-13.
- Blackstone has launched Uniquity to propel Merck's Phase 2 high-potency TSLP antibody.
- Innovent Biologics is conducting a Phase I study on IBI3002, a dual-function antibody that targets both IL-4Rα and TSLP.
- Sanofi and Regeneron are developing SAR443765, a novel biologic targeting TSLP and IL-13 for asthma treatment.
- Teva Pharmaceuticals and Biolojic Design have entered an exclusive agreement to develop bispecific antibodies targeting TSLP and IL-13.
- GSK has recently acquired Aiolos Bio for $1 billion upfront to enhance its respiratory biologics portfolio with AIO-001, a Phase 2 long-acting anti-TSLP monoclonal antibody.

These strategic advancements highlight the increasing interest in TSLP antibodies as a means of treating a variety of inflammatory and allergic conditions. Perseus Therapeutics aims to make a significant impact in this evolving field with its innovative approach to preventing hair loss among cancer patients, a common and distressing side effect of cancer treatments, and addressing other inflammatory diseases.

"Perseus Therapeutics is dedicated to advancing the science of TSLP antibodies to address critical unmet medical needs," stated Joseph Hernandez, Chairman and Founder of Perseus Therapeutics. "Our efforts are focused not only on improving the quality of life for cancer patients by preventing hair loss but also on providing effective treatments for various inflammatory conditions."

Perseus Therapeutics is a biopharmaceutical company spun out from Duke University, committed to developing innovative therapies for cancer patients and individuals suffering from inflammatory diseases. Based in New York City, the company is at the cutting edge of antibody research and development, striving to offer new hope and better outcomes for patients around the world.

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