What are the side effects of Diflunisal?

Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to manage mild to moderate pain, inflammation, and fever. While it can be effective in treating symptoms associated with conditions like arthritis, it is important to be aware of the potential side effects that can occur with its use. Understanding these side effects can help you make informed decisions about your treatment and know when to seek medical attention.

Gastrointestinal Issues: One of the most common side effects of diflunisal involves the gastrointestinal (GI) system. Patients may experience symptoms such as nausea, vomiting, diarrhea, and indigestion. In some cases, more serious gastrointestinal problems like stomach ulcers, bleeding, and perforation can occur. These severe conditions may present as black or bloody stools, severe abdominal pain, or vomiting that looks like coffee grounds. It is important to inform your healthcare provider if you experience any of these symptoms.

Cardiovascular Risks: Diflunisal, like other NSAIDs, may increase the risk of serious cardiovascular events, such as heart attack and stroke. This risk may be higher in patients with pre-existing heart disease or those who use the medication for extended periods. Symptoms to watch for include chest pain, shortness of breath, weakness, and slurred speech. Immediate medical attention is crucial if any of these symptoms arise.

Kidney Function: Long-term use of diflunisal can impact kidney function. Symptoms of kidney issues may include changes in urination patterns, swelling in the legs and feet, and fatigue. In rare cases, acute kidney failure can occur. Regular monitoring of kidney function through blood tests may be recommended by your healthcare provider if you are on long-term diflunisal therapy.

Liver Concerns: Though less common, diflunisal can cause liver damage. Symptoms of liver issues may include yellowing of the skin or eyes (jaundice), dark urine, severe fatigue, and pain in the upper right part of the abdomen. Liver function tests can help monitor the health of your liver while taking this medication.

Allergic Reactions: Some individuals may have allergic reactions to diflunisal, which can range from mild to severe. Mild reactions might include skin rashes and itching, while more severe reactions could involve swelling of the face, lips, and throat, leading to difficulty breathing. Anaphylaxis, a life-threatening allergic reaction, requires immediate medical attention.

Hematologic Effects: Diflunisal can have effects on blood components, including a decreased ability to clot, increased risk of bleeding, and anemia. Symptoms may include unusual bruising or bleeding, prolonged bleeding from cuts, and feeling unusually tired. Blood tests can help monitor for these potential issues.

Central Nervous System Effects: Some patients may experience side effects related to the central nervous system, such as dizziness, headache, drowsiness, and confusion. These symptoms can affect daily activities and the ability to operate machinery or drive.

Skin Reactions: Though rare, serious skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis can occur. Symptoms include severe skin rash, blistering, and peeling of the skin. Immediate medical attention is necessary if these symptoms develop.

Pregnancy and Breastfeeding: Diflunisal is generally not recommended during pregnancy, especially in the third trimester, as it may cause complications for both the mother and the unborn baby. It is also not recommended for breastfeeding mothers, as the drug can pass into breast milk and affect the infant.

In conclusion, while diflunisal can be an effective medication for managing pain and inflammation, it is essential to be aware of its potential side effects. Regular communication with your healthcare provider, along with routine monitoring, can help manage these risks and ensure the safe use of the medication. If you experience any concerning symptoms while taking diflunisal, seek medical attention promptly.