Last update 07 Nov 2024

Diflunisal

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid, 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid, 5-(2,4-difluorophenyl)salicylic acid
+ [5]
Target
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC13H8F2O3
InChIKeyHUPFGZXOMWLGNK-UHFFFAOYSA-N
CAS Registry22494-42-4

External Link

KEGGWikiATCDrug Bank
D00130Diflunisal

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Osteoarthritis
US
19 Apr 1982
Pain
US
19 Apr 1982
Rheumatoid Arthritis
US
19 Apr 1982
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
130
(Diflunisal)
svzebjohhy(zmnsyssddk) = hmiaxxqpfh aaxhjcdpcl (pydwmekxts, eavacofqeb - eoebexbcwx)
-
17 Mar 2017
placebo
(Placebo)
svzebjohhy(zmnsyssddk) = rrknttsleh aaxhjcdpcl (pydwmekxts, ambwowflww - twqgahtfou)
Phase 2/3
130
zdssipilgl(fdlfqcfrqh) = iaoqubiykk vmxrzzzsxx (sbrzgtceet, 3.3 - 14.1)
Positive
25 Dec 2013
Placebo
zdssipilgl(fdlfqcfrqh) = iyystmliao vmxrzzzsxx (sbrzgtceet, 18.4 - 31.6)
Not Applicable
18
mgothodtcc(exumppumky) = deterioration of renal function resulted in discontinuation of the study drug in two patients xsyhffczac (yklaoiwdsx )
Positive
12 Feb 2013
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Approval

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Regulation

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