What are the side effects of Letermovir?

Letermovir, sold under the brand name Prevymis, is an antiviral medication primarily used to prevent cytomegalovirus (CMV) infection in individuals who have undergone allogeneic hematopoietic stem cell transplantation. Like any medication, Letermovir may produce side effects, which can range from mild to severe. Understanding these potential side effects is crucial for patients and healthcare providers to manage and mitigate any adverse reactions effectively.

One of the more commonly reported side effects of Letermovir is gastrointestinal discomfort. This includes symptoms such as nausea, vomiting, and diarrhea. Often, these symptoms are mild and manageable with supportive care, but in some cases, they may require medical attention if they become severe or persistent.

Headaches are another frequent complaint among Letermovir users. These headaches can vary in intensity and may be accompanied by dizziness. While over-the-counter pain medications can often alleviate these symptoms, it is essential to consult a healthcare provider if they persist or worsen.

Liver function abnormalities have also been observed in some patients taking Letermovir. These abnormalities are typically detected through routine blood tests and may not cause noticeable symptoms. However, in rare cases, patients may experience jaundice, fatigue, or dark urine, which require prompt medical evaluation.

Another serious but less common side effect is the development of hypertension or elevated blood pressure. Patients with pre-existing hypertension or cardiovascular conditions should be monitored closely while on Letermovir. Adjustments to antihypertensive medications may be necessary to manage this side effect effectively.

Additionally, Letermovir may cause hypersensitivity reactions, including rash, itching, and in rare cases, anaphylaxis. Any signs of hypersensitivity should be reported to a healthcare provider immediately, as they may necessitate discontinuation of the medication and initiation of appropriate treatment.

Patients may also experience musculoskeletal side effects, such as muscle cramps or weakness. While these symptoms are generally mild, they can impact the quality of life and should be discussed with a healthcare provider to determine the best course of action.

It's important to note that while these side effects are possible, not all patients will experience them, and some individuals may tolerate the medication without any issues. Regular monitoring and communication with healthcare providers can help manage any side effects that do occur, ensuring the continued efficacy and safety of the treatment.

In conclusion, Letermovir is a valuable medication for preventing CMV infection in transplant patients, but it is not without potential side effects. Patients should be aware of the possible gastrointestinal issues, headaches, liver function abnormalities, hypertension, hypersensitivity reactions, and musculoskeletal symptoms. By working closely with their healthcare providers, patients can navigate these side effects and maintain their health and well-being during treatment.