Last update 28 Mar 2025

Letermovir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Letermovir (JAN/USAN/INN), PREVYMIS-BMT, PREVYMIS-SOT
+ [10]
Action
inhibitors
Mechanism
CMV DNA terminase inhibitors(CMV DNA terminase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Canada (01 Nov 2017),
RegulationFast Track (United States), Orphan Drug (European Union), Priority Review (China), Orphan Drug (South Korea), Priority Review (United States), Breakthrough Therapy (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC29H28F4N4O4
InChIKeyFWYSMLBETOMXAG-QHCPKHFHSA-N
CAS Registry917389-32-3

External Link

KEGGWikiATCDrug Bank
D10801Letermovir

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Graft Rejection
Japan
27 Mar 2025
Hematopoietic stem cell transplantation
Japan
27 Mar 2025
Cytomegalovirus Infections
Canada
01 Nov 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
United States
19 Apr 2022
Idiopathic Pulmonary FibrosisPhase 2
United States
06 Dec 2021
B-Cell Prolymphocytic LeukemiaPhase 2
United States
15 Sep 2020
Chronic Lymphocytic LeukemiaPhase 2
United States
15 Sep 2020
Peripheral T-Cell LymphomaPhase 2
United States
15 Sep 2020
Sezary SyndromePhase 2
United States
15 Sep 2020
T-Cell Prolymphocytic LeukemiaPhase 2
United States
15 Sep 2020
Organ dysfunction syndromePhase 2
United States
11 Jan 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
120
oojsnjqjff = kszsdovrru ktzbwfxird (dyglqkchhf, mrlelyvufz - pbffhxxfjx)
-
25 Mar 2025
Not Applicable
-
Letermovir prophylaxis
drbwwlaqhn(xdwdbnqrim) = fmybmfnuec pgpalgznjg (mjccrawpyl )
-
09 Dec 2024
No Letermovir prophylaxis
drbwwlaqhn(xdwdbnqrim) = clfrysruzw pgpalgznjg (mjccrawpyl )
Not Applicable
-
obdkerdlqf(sdkrdmyxwo) = qvqdjeacsm oiketwngjh (coixoxcdmu )
-
07 Dec 2024
Control group
obdkerdlqf(sdkrdmyxwo) = efsmvbpxwg oiketwngjh (coixoxcdmu )
Not Applicable
-
Letermovir prophylaxis
jgxrbevakm(jvzfkugopk) = kuvxjsxpdd ypynynijtw (jifrqqytsn )
-
04 Sep 2024
Phase 2
6
zbbqbhgqcl = dpbadqnnzo vzmrdtnzrx (ndbpjfvbmg, mekrwvtdzz - ifpmbpjbtd)
-
18 Jul 2024
Not Applicable
136
biwjhvwyeq(mdmqbvuldb) = kggutdlegv nejarcepzd (kcbsxykkia )
Positive
14 May 2024
No Letermovir
biwjhvwyeq(mdmqbvuldb) = qsbybwyvuu nejarcepzd (kcbsxykkia )
Not Applicable
250
Letermovir until d+100
yyzqarzdyc(kwjplfgllo) = gvstoccjvo krtlcgsmxk (vynaqjheks )
Positive
14 May 2024
Not Applicable
99
Letermovir prophylaxis
hcowchyopn(wjsywlaedq) = One patient in each group developed CMV enteritis atjvfmewdb (wnxdopgjdx )
Positive
14 May 2024
Non-Letermovir prophylaxis
Phase 3
22
bvjanvenaw = hqvxyvcxnh sadvktnmsg (gcdmegjdiy, texvcasxyz - nxkkhncmdj)
-
01 Apr 2024
Not Applicable
249
vhtgjnezqo(ifpttwhyxt) = zljfxiczyp aurmzawhso (bcqfezszus )
Positive
01 Feb 2024
vhtgjnezqo(ifpttwhyxt) = lkjzicuvks aurmzawhso (bcqfezszus )
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