Master Guanfacine Search on Synapse

Guanfacine (Brandname Tenex、Intuniv、Estulic) is a medication that acts as a centrally acting antihypertensive agent and an α2-adrenoceptor agonist. Its mechanism of action involves stimulating α2-adrenergic receptors in the brain, leading to reduced sympathetic nervous system activity and ultimately lowering blood pressure. Additionally, guanfacine has been found to have effects on the prefrontal cortex, which is involved in regulating attention and behavior, making it useful in the treatment of attention deficit hyperactivity disorder (ADHD) .Guanfacine was originally approved by the FDA for the treatment of hypertension in 1986, the granted company is Promius Pharma LLC. Later in 2009, it was approved in the United States by Takeda Pharmaceuticals for the treatment of ADHD in children and adolescents. It is currently approved in multiple countries around the world. Click on the image below to begin the exploration journey of Guanfacine through the Synapse database!

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