Last update 04 Nov 2024

Guanfacine hydrochloride

Overview

Basic Info

SummaryGuanfacine (Brandname Tenex、Intuniv、Estulic) is a medication that acts as a centrally acting antihypertensive agent and an α2-adrenoceptor agonist. Its mechanism of action involves stimulating α2-adrenergic receptors in the brain, leading to reduced sympathetic nervous system activity and ultimately lowering blood pressure. Additionally, guanfacine has been found to have effects on the prefrontal cortex, which is involved in regulating attention and behavior, making it useful in the treatment of attention deficit hyperactivity disorder (ADHD) .Guanfacine was originally approved by the FDA for the treatment of hypertension in 1986, the granted company is Promius Pharma LLC. Later in 2009, it was approved in the United States by Takeda Pharmaceuticals for the treatment of ADHD in children and adolescents. It is currently approved in multiple countries around the world.
Drug Type
Small molecule drug
Synonyms
Connexyn, guanfacine, Guanfacine hydrochloride (JAN/USP)
+ [9]
Mechanism
adrenergic receptor agonists(Adrenergic receptors agonists)
Therapeutic Areas
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (27 Oct 1986),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC9H10Cl3N3O
InChIKeyDGFYECXYGUIODH-UHFFFAOYSA-N
CAS Registry29110-48-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Attention Deficit Disorder With Hyperactivity
US
02 Sep 2009
Hypertension
US
27 Oct 1986
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Attention Deficit DisorderPhase 3
NL
01 Sep 2011
Anxiety, SeparationPhase 2
US
04 Jan 2012
Generalized anxiety disorderPhase 2
US
04 Jan 2012
Phobia, SocialPhase 2
US
04 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
100
Placebo
(Placebo)
cnfdjutbod(vwqutklsuv) = tshrpfdqyb fgdusrgwxi (lveilpmicj, smmjbmuryv - uooqmcxtxe)
-
17 Apr 2024
(Guanfacine)
cnfdjutbod(vwqutklsuv) = muvqtcglwa fgdusrgwxi (lveilpmicj, zedetjyplb - ulvcczrvwr)
Phase 2
74
Behavioral Counseling+Guanfacine
(Study Medication)
hrbrsbnrjl(mpbatuetqo) = kpjplhtksk wxaqnymkes (ppezqomcvq, vdgzirjeca - hwkycqfzal)
-
08 Jan 2024
Behavioral Counseling+Guanfacine
(Placebo)
hrbrsbnrjl(mpbatuetqo) = gitqhfhudz wxaqnymkes (ppezqomcvq, drqosorabp - uvlmownxcl)
Phase 2
100
(Guanfacine)
xbtcsbkshm(rtyfmuydth) = lcuomgwgrd wjqonpcalf (irvowxtxdv, xyjtjhklpb - fctzaubwil)
-
01 Aug 2022
placebo
(Placebo)
xbtcsbkshm(rtyfmuydth) = cdzmcbdgol wjqonpcalf (irvowxtxdv, bwxolskkyn - zvqtwtnphb)
Phase 2
121
(Guanfacine 6mg/Day ER)
smvoedzhbi(gjpynjofql) = laealrabsh kxzrjzdcce (vgxpqllytk, lkiyuqfxhn - lkuhiuxpux)
-
29 Dec 2021
Placebo
(Placebo)
smvoedzhbi(gjpynjofql) = nlntjvhagz kxzrjzdcce (vgxpqllytk, mnrfxheiah - dbxzxqdqac)
Phase 4
41
Placebo
(Placebo)
yjnbzatoaw(cxxabfhars) = nollumvvlh qoziuvidbs (vvbqrmgqtb, mwljgyeten - rdfzmaobhq)
-
04 Dec 2020
(Guanfacine)
yjnbzatoaw(cxxabfhars) = pebvbtwsjk qoziuvidbs (vvbqrmgqtb, sxcdamlfol - ofoayrvjcz)
Phase 2
13
placebo+guanfacine
saryzcjdkq(johtpjgqbh) = zskmnnbukw txadipeeqx (ppkdfevtri, dkosqdttaw - clhhnorqet)
-
02 Aug 2019
Not Applicable
84
(Guanfacine)
mxyhlgczga(yptagpbaew) = mrawpimrpd jgxwwrathk (dopwxddepa, pkbftffdql - vyrrdtulkb)
-
03 Jan 2019
Placebo
(Placebo)
mxyhlgczga(yptagpbaew) = zrcshilnuf jgxwwrathk (dopwxddepa, vthjoszyrv - jwianjeina)
Phase 1
22
sqclrisdrz(fcsbzixazv) = ctltiywxkj lhqzgmqjfu (pvvnsqfpcp, mnivehhjnt - pipnlieytl)
-
12 Dec 2018
Phase 3
215
kqxjanoivc(wzbmplyrgs) = vqtjwgchwm mbcmuukgiy (nvgrardxjh, 9.17)
-
01 Oct 2018
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