Empagliflozin is the first Sodium-Glucose Co-Transporter-2 (SGLT2) inhibitor to statistically significantly reduce the risk of hospitalization for any cause compared to a placebo in patients with CKD.

PRGN-2012 is a therapeutic vaccine that achieves therapeutic effects through immune stimulation.

Vertex Pharmaceuticals, Inc. is a biopharmaceutical company that was founded in 1989 and is headquartered in Massachusetts, United States.

A recent study has found that elevated levels of the protein MAP1B result in neuronal autophagy defects closely linked to human ASD. Treating FXS and ASD with rapamycin, a drug that inhibits autophagy, may be a promising potential therapy.

Otsuka Holdings Co., Ltd. is a pharmaceutical organization based in Tokyo-to, Japan. It was founded in 1921 and has since become a prominent player in the biomedicine industry.

These limitations include the absence of high-resolution structures for numerous proteins, the challenge of accurately predicting active sites, defining binding pockets for novel targets with multiple domains, and anticipating allosteric sites.

Daiichi Sankyo Co., Ltd. is a pharmaceutical organization founded in 2005 and based in Tokyo, Japan. The company operates in the field of biomedicine and has a diverse portfolio of drugs targeting various therapeutic areas.

On July 23, CanSino Biologics announced that its recombinant shingles vaccine CS-2032, developed in collaboration with Vaccitech, has received clinical trial approval from Health Canada.

UCB SA is a pharmaceutical organization that was founded in 1928 and is located in Brussels Hoofdstedelijk Gewest, Belgium.

Ritlecitinib, trade name LITFULO, is a small molecule drug targeting JAK3 and TEC (see Figure 2-9 for molecular structure).

On July 24, 2023, Alnylam announced that it has reached a strategic agreement with Roche to develop and commercialize Zilebesiran, Alnylam's RNAi therapeutic drug for the treatment of hypertension.

Organon & Co. is a pharmaceutical organization founded in 2020 and based in Noord-Brabant, Netherlands. The company operates in the field of biomedicine and focuses on the development of drugs for various therapeutic areas.