Reflex Sympathetic Dystrophy

New delivery system, designed for Abbott's Proclaim™ DRG neurostimulation system, promotes efficient placement of neurostimulation leads on the dorsal root ganglion (DRG) Abbott's system is the only FDA-approved DRG technology for the treatment of complex regional pain syndrome (CRPS) Type 1 and Type 2 of the lower extremities, considered the world's most painful conditions1 ABBOTT PARK, Ill., April 2, 2025 – Abbott today announced the launch of its neuromodulation business’ next-generation delivery system, which will be used to streamline the implantation process for electrodes used as part of its Proclaim™ DRG neurostimulation system. The new system is intended to streamline the procedure when doctors implant the system in patients who are suffering from complex regional pain syndrome (CRPS) Type 1 and causalgia (CRPS Type 2) of the lower extremities, rare conditions that are considered more painful than childbirth or limb amputation.1 The dorsal root ganglion – or DRG – is a cluster of nerve cells found along the spine that control pain signals from specific areas of the body, including the pelvis, groin, hip, knee, ankle and foot. Abbott developed Proclaim DRG therapy specifically to target this cluster of nerves, becoming the first and only DRG technology approved to treat CRPS of the lower limbs. The DRG neurostimulation system consists of a small battery, often referred to as an implantable pulse generator (IPG), that produces the electrical stimulation, and thin wires, known as leads, that delivers the stimulation to a targeted area, in this case the DRG. Once implanted, targeted stimulation in this area can help address symptoms by disrupting pain signals before they can reach the spinal cord or brain. Four out of five people using Abbott’s Proclaim DRG neurostimulation system for their CRPS have reported significant pain relief,2 with an average 81% reported drop in pain intensity.2 The delivery system is an important part of the Proclaim DRG system because it enables physicians to carefully navigate and access the precise anatomy of the DRG when placing the system's electrodes. Designed for ease of use, the next-generation delivery system offers enhanced durability and maneuverability, which can streamline the implant procedure.2 "Because of the distinct position of the dorsal root ganglion near the spinal cord, it can be challenging to proficiently place leads there, which can limit the number of physicians who feel comfortable performing this procedure," said Timothy Deer, M.D., DABPM, president and chief executive officer of the Spine and Nerve Centers of the Virginias in Charleston, W.Va."The improved design of the new delivery system enhances maneuverability for physicians – potentially allowing more patients to experience the life-changing benefits of DRG stimulation." Placing a DRG lead involves accessing the epidural space with a needle and maneuvering the lead toward the DRG under image guidance. This cutting-edge delivery system is intended to allow physicians to implant the DRG system more efficiently. "Research shows treating CRPS with targeted DRG neurostimulation results in significantly better outcomes in terms of pain relief and functional improvements than traditional spinal cord stimulation approaches,"2,3 said Allen Burton, M.D., medical director of neuromodulation at Abbott. "Abbott is continually working to improve DRG technology to better assist physicians in improving patient outcomes. The easier the procedure, the more patients will benefit from it, helping them to live more active, fuller lives with their chronic pain under control." Considered the world's most painful chronic condition, CRPS is the result of the body overreacting to an injury or surgery and producing far greater pain signals and inflammation than is normal.4 CRPS is categorized as either Type 1 (also called reflex sympathetic dystrophy), which occurs without any detectable nerve damage, and Type 2 (also called causalgia), which happens after known nerve damage. While many affected by CRPS will have mild symptoms that can gradually improve over several months or years, some will suffer from long-term, severe pain and disability.4 For U.S. important safety information on the Abbott Proclaim DRG neurostimulation system, visit: https://bit.ly/3SheU6s About Abbott Abbott is a global healthcare leader that helps people live more fully at all stages of life. Our portfolio of life-changing technologies spans the spectrum of healthcare, with leading businesses and products in diagnostics, medical devices, nutritionals and branded generic medicines. Our 114,000 colleagues serve people in more than 160 countries. Connect with us at www.abbott.com and on LinkedIn, Facebook, Instagram, X and YouTube. 1Lee DH, Noh EC, Kim YC, et al. Risk Factors for Suicidal Ideation among Patients with Complex Regional Pain Syndrome. Psychiatry Investig. 2014;11(1):32-38. doi:10.4306/pi.2014.11.1.32. 2Deer TR, Levy RM, Kramer J, et al. Dorsal root ganglion stimulation yielded higher treatment success rate for complex regional pain syndrome and causalgia at 3 and 12 months: a randomized comparative trial. Pain. 2017;158(4):669-681. doi:10.1097/j.pain.0000000000000814. 3Gopal, H., Fitzgerald, J., & McCrory, C. (2016). Spinal cord stimulation for FBSS and CRPS: A review of 80 cases with on-table trial of stimulation. Journal of back and musculoskeletal rehabilitation, 29(1), 7–13. https://doi.org/10.3233/BMR-150608. 4National Institute of Neurological Disorders and Stroke. March 8, 2023. Complex Regional Pain Syndrome. https://www.ninds.nih.gov/health-information/disorders/complex-regional-pain-syndrome. Accessed Aug. 30, 2023.

The Netflix documentary Take Care of Maya has raised awareness of, and many questions about, CRPS. First among them is, "Do I have it." Here is how to self-diagnose the signs of CRPS and where to look for the right medical help. MILFORD, Conn., July 14, 2023 /PRNewswire/ -- CRPS, or Complex Regional Pain Syndrome, is a serious, incurable disease that may not be as rare as it is rarely diagnosed. The good news is that if it is diagnosed early, it can be put into remission, often for a lifetime. RSDSA, the international CRPS support group, shows you how to tell if you or a loved one may have CRPS and where to get the right help. Just follow this link to find out if You or Your Child Has CRPS. Continue Reading CRPS, also known as Reflex Sympathetic Dystrophy, is rare, but as more pediatricians become aware of it, it may not be so rare in all ages as it has been rarely diagnosed. That's important because treatment within a month or two of onset can avoid long-term disability and a lifetime of misery in many cases. The Netflix documentary "Take Care of Maya" has raised awareness of, and many questions about CRPS. RSDSA has answers. Tweet this If you or a loved one has pain that is getting worse, especially if it is more severe than one would expect from the original injury, trauma, or medical procedure, and that pain is: Described as deep, aching, cold, or burning, especially with increased skin sensitivity, Persistent and excessive and does not subside with healing, Moderate to severe caused by something that should not cause pain at all such as the touch of clothing, touching a room temperature metal or stone object, or taking a shower, In areas that should not be painful at all, Accompanied by abnormal swelling, sweating, skin color changes, hair and/or nail growth, Associated with abnormal skin temperature, that is, one side of the body, a foot, or a hand, warmer or colder than the other by more than 1°C or 2°F, Limited range of motion, weakness, or other motor disorders including paralysis or dystonia, which is involuntary, repetitive movement. Follow the link to our article to learn more about how to find professional help. For more information on CRPS and RSDSA, visit the RSDSA website. Contact James Broatch, Executive Vice President 203-877-3790 SOURCE RSDSA

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