Last update 01 Nov 2024

Chronic superficial gastritis

Last update 01 Nov 2024

Basic Info

Synonyms

CSG - Chronic superficial gastritis, Chronic superficial gastritis, Chronic superficial gastritis (diagnosis)

+ [7]

Introduction

Persistent inflammation of the superficial portion of the gastric mucosa. It is a condition that predisposes to the development of ulcer and mucosa-associated lymphoid tissue lymphoma.

Drugs associated with Chronic superficial gastritis

Bismuth Pectin

Target-

Mechanism-

Active Org.

Shanxi Xinbaoyuan Pharmaceutical Co., Ltd.

Originator Org.

Shanxi Xinbaoyuan Pharmaceutical Co., Ltd.

Active Indication

Gastritis [+1]

Inactive Indication

Chronic superficial gastritis [+2]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date01 Jan 1992

Canghuo Pingwei Granules

Target-

Mechanism-

Active Org.-

Originator Org.-

Active Indication

Chronic superficial gastritis

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Xiasa Dexi Capsule

Target-

Mechanism-

Active Org.

Tibetan Hospital of Ruoergai County, Sichuan Province [+2]

Originator Org.-

Active Indication

Chronic superficial gastritis [+1]

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Chronic superficial gastritis

CTRI/2024/10/074746 / Not yet recruitingPhase 4

To Evaluate Efficacy & safety of Dipya Acidity Relief Tablet in Management of chronic Gastritis. - NIL

Start Date15 Oct 2024

Sponsor / Collaborator-

ChiCTR2200062781 / SuspendedEarly Phase 1IIT

Study on the auxiliary protective effect of Jinshidan gastric mucosa protective powder on gastric mucosa

Start Date15 Aug 2022

Sponsor / Collaborator

Affiliated Hospital of Jiangnan University

CTR20220690 / CompletedNot Applicable

胶体果胶铋干混悬剂人体药代动力学比较研究

[Translation] Comparative study on the pharmacokinetics of colloidal bismuth pectin suspension in healthy volunteers

本试验旨在研究单次空腹口服湖南华纳大药厂股份有限公司研制、生产的胶体果胶铋干混悬剂〔华纳福 ® ，150 mg（以铋计）〕的药代动力学特征；以 ToraLaboratories S.L.持证的枸橼酸铋钾片〔Gastrodenol ® ，120 mg（以 Bi 2 O 3 计）〕为参比制剂，证明受试制剂人体铋吸收不高于参比制剂。

[Translation]

The purpose of this study is to study the pharmacokinetic characteristics of a single oral fasting dose of colloidal pectin bismuth dry suspension [Huanafu ® , 150 mg (calculated as bismuth)] developed and produced by Hunan Huana Pharmaceutical Co., Ltd.; using potassium citrate bismuth tablets [Gastrodenol ® , 120 mg (calculated as Bi 2 O 3)] certified by Tora Laboratories S.L. as the reference preparation, to prove that the bismuth absorption of the test preparation in the human body is not higher than that of the reference preparation.

Start Date30 Mar 2022

Sponsor / Collaborator

Hunan Warrant Pharmaceutical Co., Ltd.

100 Clinical Results associated with Chronic superficial gastritis

100 Translational Medicine associated with Chronic superficial gastritis

0 Patents (Medical) associated with Chronic superficial gastritis

395

Literatures (Medical) associated with Chronic superficial gastritis

31 Aug 2024·Cureus

Erythrasma: Pathogenesis and Diagnostic Challenges

Article

Author: Martínez-Ortega, Jesús Iván ; Franco González, Samantha

Erythrasma is a common chronic superficial bacterial infection caused by Corynebacterium minutissimum, a lipophilic, diphtheroid, filamentous, gram-positive bacillus and normal inhabitant of the skin flora. Commonly found in intertriginous spaces, this bacterium releases a porphyrin that causes lesions to fluoresce under a Wood's lamp, aiding diagnosis. Despite its clinical relevance, the pathogenesis remains understudied. We present a case of a 43-year-old woman with a history of hypertension, type 2 diabetes mellitus, and obesity who exhibited an erythematous eczematous plaque with characteristic coral-red fluorescence under Wood's lamp. The diagnosis was confirmed through negative skin scrapings for candidiasis and dermatophytosis. A two-week course of topical clindamycin resulted in complete resolution. Given the condition's frequent coexistence with other pathologies, accurate diagnosis and effective treatment are essential. Topical treatments are usually more convenient. The hypothesis that hydrophobic and lipophilic interactions in intertriginous areas contribute to the pathogenesis of erythrasma requires further experimental validation.

17 Aug 2024·Biomarkers

The diagnostic value of serum trefoil factor 3 and pepsinogen combination in chronic atrophic gastritis: a retrospective study based on a gastric cancer screening cohort in the community population

Article

Author: Gao, Xiaojuan ; Dong, Shengrong ; Zhao, Jiamin ; Lv, Jiale ; Zhan, Qiang ; Yang, Mei ; Tian, Wenying ; Zhang, Xiaoxue ; Han, Jinglue ; Hu, Feifan ; An, Fangmei ; Shen, Yao

BACKGROUNDChronic atrophic gastritis (CAG) is an important precursor of gastric cancer(GC), and there is currently a lack of reliable non-invasive diagnostic markers. This study aims to find a biomarker for non-invasive screening of CAG in the community.METHODSA total of 540 individuals were enrolled (test set = 385, validation set = 155). ROC curve analysis was used to evaluate the diagnostic significance of serum Trefoil Factor 3 (TFF3) alone or in combination with pepsinogen (PG) for CAG in the test and validation set. Furthermore, the diagnostic value of TFF3 and PG in different Helicobacter pylori (H. pylori) infection states was studied.RESULTSWhen compared with chronic superficial gastritis (CSG), the expression level of serum TFF3 in the CAG was higher (27 ng/ml vs 19.61, P < 0.001). ROC curve analysis found that the sensitivity, specificity, and area under the curve (AUC) of CAG diagnosis using serum TFF3 alone at the optimal cut-off value of 26.55 ng/ml were 0.529, 0.87, and 0.739, respectively. When TFF3 was combined with The Ratio of PGI to PGII (PGR), the AUC and specificity reached 0.755 and 0.825, respectively. TFF3 individual or combined with PGR had good predictive value, especially in the H. Pylori negative patients.CONCLUSIONTFF3 combined with PGR can effectively predict CAG, especially in patients with H. pylori negative.

01 Aug 2024·Journal of Gastrointestinal Oncology

CMTM4 inhibits gastric tumorigenesis and metastasis

Article

Author: Matsas, Silvio ; Ding, Shigang ; Han, Xiurui ; Meng, Qiao ; Sun, Qinghua ; Zhang, Hejun ; de Melo, Fabrício Freire ; Hao, Xinyu ; Gong, Yueqing ; Fu, Weiwei ; Zhang, Jing ; Zheng, Huiling ; Melo, Fabrício Freire de ; Ning, Jing

BackgroundCKLF-like MARVEL transmembrane domain-containing 4 (CMTM4) is involved in immune regulation and tumor progression; however, its role in gastric cancer (GC) remains unclear. This study explored the role and mechanism of CMTM4 in GC.MethodsImmunohistochemistry was used to analyze CMTM4 expression in human gastric biopsied cells from patients with GC (N=23) or chronic superficial gastritis (N=23). To investigate the function of CMTM4 in GC cells, the gene CMTM4 was knocked down and overexpressed in human gastric adenocarcinoma cell line AGS. The gene CMTM4 was overexpressed in AGS cells and human gastric cell line SGC7901. Cell Counting Kit 8 (CCK-8) and cell clonogenic assays were used to analyze the proliferation of the GC cells. Flow cytometry was used to analyze the effects of CMTM4 on apoptosis and the cell cycle. Wound healing and transwell assays were used to analyze the migration and invasion of the gastric cells, respectively. The mechanism of CMTM4 in GC cells was explored using the tandem mass tags (TMTs) proteome and verified by western blot analysis.ResultsCMTM4 expression was more downregulated in the human GC tissues than the gastritis tissues. CMTM4 overexpression significantly inhibited the proliferation, migration, and invasion of the GC cells, whereas CMTM4 knockdown enhanced gastric cell proliferation (P>0.05), migration (P>0.05), and invasion (P>0.05). Flow cytometry showed that CMTM4 promoted apoptosis and resulted in G1/S arrest in the GC cells. In addition, the proteome and western blot results showed that STAT1 was significantly upregulated, and the STAT1 signaling pathways were enriched in the GC cells overexpressing CMTM4.ConclusionsOur results suggest that CMTM4 plays a tumor-suppressive role in GC and may affect the growth, migration, and invasion of GC cells through the STAT1 signaling pathway. CMTM4 might have potential value as a prognosis marker and potential therapeutic target for GC therapy.

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Chronic superficial gastritis

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