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Last update 08 May 2025

Chronic superficial gastritis

Last update 08 May 2025

Basic Info

Synonyms

CSG - Chronic superficial gastritis, Chronic superficial gastritis, Chronic superficial gastritis (diagnosis)

+ [7]

Introduction

Persistent inflammation of the superficial portion of the gastric mucosa. It is a condition that predisposes to the development of ulcer and mucosa-associated lymphoid tissue lymphoma.

Drugs associated with Chronic superficial gastritis

Bismuth Pectin

Target-

Mechanism-

Active Org.

Shanxi Xinbaoyuan Pharmaceutical Co., Ltd.

Originator Org.

Shanxi Xinbaoyuan Pharmaceutical Co., Ltd.

Active Indication

Gastritis [+1]

Inactive Indication

Chronic superficial gastritis [+2]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

China

First Approval Date01 Jan 1992

Canghuo Pingwei Granules

Target-

Mechanism-

Active Org.-

Originator Org.-

Active Indication

Chronic superficial gastritis

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Xiasa Dexi Capsule

Target-

Mechanism-

Active Org.

Ruoergai County Institute of Tibetan Medicine, Sichuan Province [+2]

Originator Org.-

Active Indication

Chronic superficial gastritis [+1]

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Chronic superficial gastritis

CTRI/2024/10/074746

/ Not yet recruitingPhase 4

To Evaluate Efficacy & safety of Dipya Acidity Relief Tablet in Management of chronic Gastritis. - NIL

Start Date15 Oct 2024

Sponsor / Collaborator-

ChiCTR2200062781

/ SuspendedEarly Phase 1IIT

Study on the auxiliary protective effect of Jinshidan gastric mucosa protective powder on gastric mucosa

Start Date15 Aug 2022

Sponsor / Collaborator

Affiliated Hospital of Jiangnan University

CTR20220690

/ CompletedNot Applicable

胶体果胶铋干混悬剂人体药代动力学比较研究

[Translation] Comparative study on the pharmacokinetics of colloidal bismuth pectin suspension in healthy volunteers

本试验旨在研究单次空腹口服湖南华纳大药厂股份有限公司研制、生产的胶体果胶铋干混悬剂〔华纳福 ® ，150 mg（以铋计）〕的药代动力学特征；以 ToraLaboratories S.L.持证的枸橼酸铋钾片〔Gastrodenol ® ，120 mg（以 Bi 2 O 3 计）〕为参比制剂，证明受试制剂人体铋吸收不高于参比制剂。

[Translation]

The purpose of this study is to study the pharmacokinetic characteristics of a single oral fasting dose of colloidal pectin bismuth dry suspension [Huanafu ® , 150 mg (calculated as bismuth)] developed and produced by Hunan Huana Pharmaceutical Co., Ltd.; using potassium citrate bismuth tablets [Gastrodenol ® , 120 mg (calculated as Bi 2 O 3)] certified by Tora Laboratories S.L. as the reference preparation, to prove that the bismuth absorption of the test preparation in the human body is not higher than that of the reference preparation.

Start Date30 Mar 2022

Sponsor / Collaborator

Hunan Warrant Pharmaceutical Co., Ltd.

100 Clinical Results associated with Chronic superficial gastritis

100 Translational Medicine associated with Chronic superficial gastritis

0 Patents (Medical) associated with Chronic superficial gastritis

400

Literatures (Medical) associated with Chronic superficial gastritis

15 Nov 2024·Medicine

Serum LINC01133 combined with CEA and CA19-9 contributes to the diagnosis and survival prognosis of gastric cancer

Article

Author: Zhang, Qifu ; Chen, Yanfang ; Hao, Meili ; Sui, Xiaomei

Background:Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are currently 2 major diagnostic biomarkers for gastric cancer (GC). The aims of study were to detect the expression of long intergenic nonprotein coding RNA 1133 (LINC01133), and to evaluate its diagnostic and prognostic value in GC. Furthermore, the clinical performance of the joint detection of LINC01133, CEA and CA19-9 was also evaluate in GC.Methods:The data were collected from 156 GC, 96 chronic superficial gastritis, 77 chronic atrophic gastritis patients and 89 healthy controls. LINC01133 expression was determined by quantitative real-time PCR. Receiver operating characteristics analysis was used to evaluate the diagnostic value of LINC01133, CEA, CA19-9 individually and jointly. Kaplan–Meier method and log-rank test were used to conduct survival comparison analysis. Cox regression was used to screen the independent prognostic factors for GC.Results:Serum LINC01133 expression was decreased in GC patients compared with chronic superficial gastritis, chronic atrophic gastritis and healthy controls, and had considerable diagnostic potential, and notably, the joint detection of LINC01133, CEA, and CA19-9 showed the highest diagnostic accuracy in distinguishing GC patients from healthy or gastritis patients. LINC01133 expression was associated with GC patients’ CEA and CA19-9 levels, tumor size, differentiation, lymph node metastasis and tumor node metastasis stage. Low LINC01133 was associated with poor GC survival, and was an independent prognostic factor for GC.Conclusion:Decreased serum LINC01133 had considerable diagnostic potential, and the joint detection of LINC01133, CEA, and CA19-9 might be a more efficient diagnostic strategy for GC patients. Reduced LINC01133 served as a prognostic biomarker to predict poor GC survival.

01 Sep 2024·Cancer Biomarkers

Machine learning identifies a 5-serum cytokine panel for the early detection of chronic atrophy gastritis patients

Article

Author: Zhang, Xiaoxue ; Wang, Yunfei ; Chan, Robin Barry ; Ge, Yan ; Junankar, Simon ; Lu, Peihua ; Zhan, Qiang ; Dong, Shengrong ; Christodoulou, Dimitris ; Shen, Yao ; Chen, Ke ; Ji, Lin ; Wen, Wen ; Ye, Wei ; Gao, Xiaojuan ; Zhao, Jiamin ; An, Fangmei

BACKGROUND: Chronic atrophy gastritis (CAG) is a high-risk pre-cancerous lesion for gastric cancer (GC). The early and accurate detection and discrimination of CAG from benign forms of gastritis (e.g. chronic superficial gastritis, CSG) is critical for optimal management of GC. However, accurate non-invasive methods for the diagnosis of CAG are currently lacking. Cytokines cause inflammation and drive cancer transformation in GC, but their utility as a diagnostic for CAG is poorly characterized. METHODS: Blood samples were collected, and 40 cytokines were quantified using a multiplexed immunoassay from 247 patients undergoing screening via endoscopy. Patients were divided into discovery and validation sets. Each cytokine importance was ranked using the feature selection algorithm Boruta. The cytokines with the highest feature importance were selected for machine learning (ML), using the LightGBM algorithm. RESULTS: Five serum cytokines (IL-10, TNF-[Formula: see text], Eotaxin, IP-10 and SDF-1a) that could discriminate between CAG and CSG patients were identified and used for predictive model construction. This model was robust and could identify CAG patients with high performance (AUC [Formula: see text] 0.88, Accuracy [Formula: see text] 0.78). This compared favorably to the conventional approach using the PGI/PGII ratio (AUC [Formula: see text] 0.59). CONCLUSION: Using state-of-the-art ML and a blood-based immunoassay, we developed an improved non-invasive screening method for the detection of precancerous GC lesions. FUNDING: Supported in part by grants from: Jiangsu Science and Technology Project (no. BK20211039); Top Talent Support Program for young and middle-aged people of Wuxi Health Committee (BJ2023008); Medical Key Discipline Program of Wuxi Health Commission (ZDXK2021010), Wuxi Science and Technology Bureau Project (no. N20201004); Scientific Research Program of Wuxi Health Commission (Z202208, J202104).

31 Aug 2024·Cureus

Erythrasma: Pathogenesis and Diagnostic Challenges

Article

Author: Martínez-Ortega, Jesús Iván ; Franco González, Samantha

Erythrasma is a common chronic superficial bacterial infection caused by Corynebacterium minutissimum, a lipophilic, diphtheroid, filamentous, gram-positive bacillus and normal inhabitant of the skin flora. Commonly found in intertriginous spaces, this bacterium releases a porphyrin that causes lesions to fluoresce under a Wood's lamp, aiding diagnosis. Despite its clinical relevance, the pathogenesis remains understudied. We present a case of a 43-year-old woman with a history of hypertension, type 2 diabetes mellitus, and obesity who exhibited an erythematous eczematous plaque with characteristic coral-red fluorescence under Wood's lamp. The diagnosis was confirmed through negative skin scrapings for candidiasis and dermatophytosis. A two-week course of topical clindamycin resulted in complete resolution. Given the condition's frequent coexistence with other pathologies, accurate diagnosis and effective treatment are essential. Topical treatments are usually more convenient. The hypothesis that hydrophobic and lipophilic interactions in intertriginous areas contribute to the pathogenesis of erythrasma requires further experimental validation.

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Chronic superficial gastritis

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