Last update 01 Nov 2024

Acute adenoviral follicular conjunctivitis

Last update 01 Nov 2024

Basic Info

Synonyms

Acute adenoviral follicular conjunctivitis, Acute adenoviral follicular conjunctivitis (disorder)

Introduction-

Drugs associated with Acute adenoviral follicular conjunctivitis

Povidone-Iodine

Target-

Mechanism-

Active Org.

Yabao Medicine Sichuan Pharmaceutical Co. Ltd. [+11]

Originator Org.

Alcon Pharmaceuticals Ltd.

Active Indication

Pressure Ulcer [+14]

Inactive Indication

Acute adenoviral follicular conjunctivitis [+2]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date01 Nov 1965

Clinical Trials associated with Acute adenoviral follicular conjunctivitis

CTR20202563 / TerminatedPhase 2

一项评估IVIEW-1201治疗急性腺病毒性结膜炎疗效的双盲、安慰剂对照、随机、Ⅱ期临床试验

[Translation] A double-blind, placebo-controlled, randomized, phase II clinical trial to evaluate the efficacy of IVIEW-1201 in the treatment of acute adenoviral conjunctivitis

为了确定IVIEW-1201治疗腺病毒结膜炎是否较安慰剂更有效。

[Translation]

To determine whether IVIEW-1201 is more effective than placebo in the treatment of adenoviral conjunctivitis.

Start Date04 Jan 2022

Sponsor / Collaborator

Iview Therapeutics Zhuhai) Co., Ltd.

[+2]

IRCT2015010920619N1 / CompletedPhase 3IIT

Comparison of the effect of consumption of 4% betadine and Fluocort eye drops with Fluocort eye drop alone on the duration of the illness of patients with Epidemic keratoconjunctivitis, referred to Nikokary Hospital

Start Date20 Feb 2015

Sponsor / Collaborator-

100 Clinical Results associated with Acute adenoviral follicular conjunctivitis

100 Translational Medicine associated with Acute adenoviral follicular conjunctivitis

0 Patents (Medical) associated with Acute adenoviral follicular conjunctivitis

Literatures (Medical) associated with Acute adenoviral follicular conjunctivitis

14 Sep 2023·Ocular Immunology and Inflammation

Molecular, Epidemiological and Clinical Assessment of Adenoviral Keratoconjunctivitis in Egypt: Institutional Study

Article

Author: Kasem, Manal Ali ; Badawi, Amani E. ; El Sayed Zaki, Maysaa ; Moemen, Dalia

PURPOSETo evaluate the frequency of Human adenovirus (HAdV) and its serotypes in keratoconjunctivitis patients who attended the outpatient clinics of Mansoura Ophthalmic Center, Egypt.METHODSConjunctival secretions and corneal scrapings were collected from patients complaining of clinically diagnosed viral keratoconjunctivitis. The molecular method for HAdV detection was performed by polymerase chain reaction (PCR) followed by restriction enzymes (REA) determination of serotypes for hexone gene.RESULTSHAdV infection was detected in 38% of samples. There were 4 serotypes of Human adenovirus species D (HAdV-D) isolated (4, 8, 37, 3), where HAdV-D8 was the most dominant. Contact with infected patient, follicular conjunctivitis and subepithelial corneal infiltrates are useful features for clinical diagnosis of adenoviral conjunctivitis.CONCLUSIONHAdV was significant etiological factor of acute follicular conjunctivitis. Accurate diagnosis of adenoviral conjunctivitis is essential for appropriate management, reducing permanent visual impairment and to limit the transmission of the virus within the community.

01 Jan 2022·Therapeutic Advances in Ophthalmology

Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19

Article

Author: Oren, Burak ; Kocabas, Dilara Ozkoyuncu

Background: The ocular manifestations of the 2019 novel coronavirus disease (COVID-19) vary from acute follicular, pseudomembranous, and hemorrhagic conjunctivitis to keratoconjunctivitis with subepithelial infiltrates and dendritic lesions. Similar to other respiratory viruses, such as adenoviruses, it is thought that COVID-19 may impact the cornea. However, its impact on the cornea and anterior segment parameters are currently poorly understood. Objective: This study aims to assess the corneal endothelial cell morphology and anterior segment parameters in patients who have recovered from COVID-19. Methods: In this cross-sectional study, the COVID-19 group comprised 34 patients who had been diagnosed with and recovered from COVID-19, while the control group comprised age- and sex-matched individuals without any systemic or ocular diseases. The endothelial cell density (ECD), coefficient of variation (CV) of cell area, hexagonal cell percentage (HEX), anterior chamber depth (ACD), central corneal thickness (CCT), horizontal anterior chamber diameter (HACD), iridocorneal angle (ICA), horizontal visible iris diameter (HVID), pupillary diameter (PD), and keratometry values (K1 and K2) were analyzed for each participant. The differences in each of these between the groups were analyzed using either an independent samples t test or a Mann–Whitney U test based on the normality of the data. Results: Regarding corneal endothelial cell morphology, the ECDs for the COVID-19 and control groups were 2278.50 ± 186.78 cells/mm2 and 2420.15 ± 222.25 cells/mm2, respectively ( p = 0.002). A significant increase was noted in CV values in the COVID-19 group compared with the control group ( p < 0.001). The HEX values for the COVID-19 and control groups were 56.26 ± 5.75 and 61.50 ± 3.63, respectively ( p < 0.001). Regarding the anterior segment parameters, no significant differences were observed between the groups ( p > 0.05). Conclusions: It was hypothesized that individuals who had recovered from COVID-19 would demonstrate a reduction in their endothelial functional preserves. A decrease in ECD and HEX and an increase in CV were observed in the individuals during their early post-recovery period from COVID-19.

19 May 2021·Ocular Immunology and InflammationQ3 · MEDICINE

Outcomes of the Ophthalmic Examinations in Patients Infected by SARS-CoV-2

Q3 · MEDICINE

Article

Author: Alagöz, Gürsoy ; Çelik, Erkan ; Çakır, Burçin ; Atum, Mahmut ; Karabay, Oğuz ; Boz, Ali Altan Ertan

Purpose: To evaluate ophthalmic examination results which were performed with slit-lamp biomicroscope, in patients with laboratory-confirmed SARS-CoV-2 infection.Methods: In the present study, 50 patients with laboratory-confirmed SARS-CoV-2 infection, were enrolled. Ophthalmic examination with slit-lamp biomicroscopy was performed and the results were evaluated.Results: The mean age of 50 patients (24 females, 26 males) included in this study, was 58,26 ± 18,91 years. In nine patients, bilateral acute follicular conjunctivitis was present. In two patients, acute anterior uveitis was seen. Optic disc and macula were normal in all patients. Preauricular lymphadenopathy (LAP) was found in 6 (12%) patients. Of these six patients, five had follicular conjunctivitis, and one had anterior uveitis.Conclusion: Acute follicular conjunctivitis with preauricular LAP and anterior uveitis were detected and no fundus pathologies were found in detailed ophthalmic examination in patients with laboratory-confirmed SARS-CoV-2 virus infection.

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Acute adenoviral follicular conjunctivitis

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