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Last update 08 May 2025

Epilepsy, Post-Traumatic

Last update 08 May 2025

Basic Info

Synonyms

Disorder, Post-Traumatic Seizure, Disorders, Post-Traumatic Seizure, EPILEPSY POSTTRAUMATIC

+ [42]

Introduction

Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)

Drugs associated with Epilepsy, Post-Traumatic

Levetiracetam

Target

SV2A

Mechanism

SV2A modulators

Active Org.

ratiopharm GmbH [+20]

Originator Org.

UCB SA

Active Indication

Epilepsia Partialis Continua [+11]

Inactive Indication

Acute repetitive seizure [+28]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

United States

First Approval Date30 Nov 1999

Clinical Trials associated with Epilepsy, Post-Traumatic

NCT06523725

/ WithdrawnPhase 2

A Randomized Controlled Trial Investigating the Safety and Efficacy of BRC-003 in Refractory Post-Traumatic Epilepsy

This prospective double blind phase II study seeks to evaluate the safety and efficacy of BRC-003, a high CBD investigational product, in the treatment of refractory PTE (Post-Traumatic Epilepsy). The research is divided into two phases: an open-label dose-finding phase (Part A) and a subsequent randomized controlled phase (Part B). This design aims to provide a thorough understanding of the investigational product's impact on seizure frequency, seizure severity, mood, anxiety, sleep, and quality of life.

Start Date01 Nov 2024

Sponsor / Collaborator

Valley Health System LLC

[+1]

NCT05353452

/ RecruitingNot ApplicableIIT

Collaborative Care for Anxiety and Depression in Posttraumatic Epilepsy

The purpose of this research is to evaluate a 6 month change in quality of life in subjects who receive collaborative care calls compared to those subjects who receive usual neurology care. This is a 2-site trial comparing a 24 week neurology-based collaborative care program to usual neurology care among a total of 60 adults with post-traumatic epilepsy.

Start Date30 Apr 2023

Sponsor / Collaborator

Wake Forest School of Medicine

NCT04945213

/ RecruitingPhase 3IIT

Biperiden for Prevention of Epilepsy in Patients With Traumatic Brain Injury

One of the most important neurological consequences following Traumatic Brain Injury (TBI) is the development of post traumatic epilepsy (PTE). Nevertheless, there is still no effective therapeutic intervention to reduce the occurrence of PTE. In previous studies with animals models of epilepsy, the biperiden decreased the incidence and intensity of spontaneous epileptic seizures besides delaying their appearance. The aim of this study is the evaluation of biperiden as antiepileptogenic drug to prevent PTE and also the determination of side effects, evaluating its cost-effectiveness in patients with moderate and severe TBI.

Start Date10 Jan 2023

Sponsor / Collaborator

Sociedade Beneficiente de Senhoras Hospital Sírio Libanês

[+6]

100 Clinical Results associated with Epilepsy, Post-Traumatic

100 Translational Medicine associated with Epilepsy, Post-Traumatic

0 Patents (Medical) associated with Epilepsy, Post-Traumatic

1,503

Literatures (Medical) associated with Epilepsy, Post-Traumatic

01 Dec 2025·Functional & Integrative Genomics

Overexpression of FTO alleviates traumatic brain injury induced posttraumatic epilepsy by upregulating NR4A2 expression via m6A demethylation

Article

Author: Xiao, Manjun ; Xiao, Enhua ; Wang, Xiaohong ; Ming, Qianwen

Post-traumatic epilepsy (PTE) is a debilitating chronic outcome of traumatic brain injury (TBI). Although FTO has been reported as a possible intervention target of TBI, its precise roles in the PTE remain incompletely understood. Here we used mild or serious mice TBI model to probe the role and molecular mechanism of FTO in PTE. The results of electroencephalography showed that frequency of epilepsy in serious TBI model mice was more obvious. Using quantitative PCR (qPCR) and western blot analysis, we demonstrated that FTO and NR4A2 were downregulated, while m6A level of NR4A2 mRNA was upregulated in the hippocampus of serious TBI mice. Functionally, FTO overexpression was found to reduce epilepsy susceptibility, blood-brain barrier (BBB) disruption and neuronal damage in TBI mice, suggested a role for FTO in PTE. In addition, RNA-binding protein immunoprecipitation and dual-luciferase assay experiment showed that NR4A2 was a target of FTO, and FTO upregulated NR4A2 expression through m6A-YTHDF2 manner. Furthermore, the molecular and histological changes caused by FTO overexpression are markedly reversed by NR4A2 knockdown in TBI mice. Collectively, our results demonstrate that FTO alleviates epilepsy susceptibility and brain injury after TBI by mediating epigenetic up-regulation of NR4A2, which implicates it as a potential therapeutic target for PTE.

01 May 2025·Epilepsy & Behavior

Chronic outcomes after mild-moderate traumatic brain injury in adult seizure-prone (FAST) and seizure-resistant (SLOW) rats: A model for understanding genetic contributions to acquired epileptogenesis?

Article

Author: Casillas-Espinosa, Pablo M ; Shad, Ali ; O'Brien, Terence J ; Leung, Wai Lam ; Perucca, Piero ; Semple, Bridgette D

Post-traumatic epilepsy (PTE) is a common, serious, long-term complication of traumatic brain injury (TBI). However, only a minority of individuals will develop epilepsy after a TBI, and the contribution of genetic predisposition to the risk of acquired epilepsy warrants further exploration. In this study, we examined whether innate, genetically determined differences in seizure susceptibility between seizure-prone FAST and seizure-resistant SLOW rat strains would influence chronic behavioral and PTE outcomes after experimental TBI. We hypothesized that FAST rats would show increased vulnerability to PTE and poorer neurobehavioral outcomes. Using the lateral fluid percussion injury model, we first determined the optimal injury parameters to generate a mild-moderate TBI in young adult FAST rats, which had previously shown high mortality to severe TBI. Then, FAST and SLOW rats underwent TBI or sham surgery, and a series of behavioral tests were performed either acutely (within 4 weeks) or chronically (more than 22 weeks) post-injury. Acutely, FAST rats showed an increased physiological response to TBI with a longer apnea duration, delayed pain response, and delayed self-righting, as well as increased acute seizure-like behavior compared to SLOW rats. Conversely, SLOW rats showed greater neuromotor deficits and weight loss sub-acutely compared to FAST rats. Chronically, while strain-specific phenotypes were observed (e.g., FAST rats showing increased anxiety-like behavior, altered nociceptive responses, and polydipsia), no TBI effects were detected. Analysis of continuous video-electroencephalographic recordings over a 1-month period starting at 6 months post-TBI did not reveal any spontaneous seizures. However, periodic epileptiform discharges were only found in FAST rats that had a TBI. Together, these findings reflect fundamental differences in chronic behavior and epileptiform discharges as a result of innate distinctions in epileptogenic susceptibility in FAST versus SLOW rats. However, a lack of spontaneous seizure activity or chronic neurobehavioral deficits in TBI animals confounded our ability to address the initial hypothesis, such that alternative injury models may be more suitable to study genetic contributions to the development of PTE.

01 May 2025·Experimental Neurology

Molecular and functional changes in GABAergic transmission during epileptogenesis in a rat model of post-traumatic epilepsy

Article

Author: Ruffolo, Gabriele ; Ndode-Ekane, Xavier Ekolle ; Pitkänen, Asla ; Puhakka, Noora ; Drexel, Meinrad ; Lipponen, Anssi ; Sperk, Günther ; Gaeta, Alessandro ; Di Iacovo, Angela ; Cifelli, Pierangelo ; Tiilikainen, Johanna ; Palma, Eleonora ; Roseti, Cristina

Traumatic brain injury (TBI) is one of the leading causes of structural epilepsy. Our objective was to investigate the molecular and functional dysregulation of GABAergic neurotransmission during a wide time window from acute to chronic phases of epileptogenesis after TBI. Perilesional and thalamic tissues sampled from a clinically relevant animal model of post-traumatic epilepsy induced by lateral fluid-percussion injury were investigated using in situ hybridization, immunohistochemistry and RNA sequencing. For functional analysis, we utilized a membrane microtransplantation technique in Xenopus oocytes in order to overcome the technical difficulties that would stem from recording directly from highly damaged lesional and perilesional brain tissues. Already at 6 to 24 h post-TBI we found a dysregulation in the expression of GABA_AR β3- and δ-subunits, which persisted for up to 4 months. Further, gene set enrichment analysis revealed a negative enrichment of GABA receptor signaling in the perilesional cortex and ipsilateral thalamus. These changes occurred in parallel to the dysregulation of the two main cation-chloride cotransporter genes (Slc12a2 and Slc12a5) both in the perilesional cortex and the ipsilateral thalamus. Our functional analysis revealed that the GABA current reversal potential (E_GABA) was shifted towards more depolarized values in the perilesional cortex and ipsilateral thalamus. Our data demonstrate a rapid onset and long-lasting duration of GABAergic dysfunction after TBI and support the hypothesis that an early treatment with agents modulating the GABAergic transmission in the thalamo-cortical-thalamic circuitry may suppress early seizures as well as prevent or slow down epileptogenesis after TBI.

News (Medical) associated with Epilepsy, Post-Traumatic

13 Jun 2022

·www.prnewswire.com

At 3.5% CAGR, Global Epilepsy Therapeutics Market Size & Share To Surpass USD 18.1 Billion by 2028 | Industry Trends, Value, Analysis & Forecast Report by Zion Market Research

NEW YORK, June 13, 2022 /PRNewswire/ -- As per Zion Market Research study, The global epilepsy therapeutics market was valued at over $13 billion in 2021 and is likely to surpass $18.1 billion by the end of 2028. The market is expected to expand at a considerable CAGR of 3.5% during the forecast period. Key Industry Insights & Finding of the Epilepsy Therapeutics Market Reports: As per the analysis shared by our research analyst, the Epilepsy Therapeutics Market is expected to grow annually at a CAGR of around 3.5 % (2022-2028). Through the primary research, it was established that the Epilepsy Therapeutics Market was valued approximately USD 13 Billion in 2021 and is projected to reach to roughly USD 18.1 Billion by 2028. This is majorly due to higher investments in R&D, increasing awareness and availability of advanced Epilepsy Therapeutics drugs in North America region. Asia Pacific is witnessing a significant growth in the global Epilepsy Therapeutics market over the upcoming years. Due government initiatives in the field, Increased awareness and technological advancement in field is fueling the growth of global Epilepsy Therapeutics market. Zion Market Research published the latest report titled as "Epilepsy Therapeutics Market By Drugs (First Generation Anti-Epileptics, Second Generation Anti-Epileptics, Third Generation Anti-Epileptics), By Distribution Channel (Hospital Pharmacy, Pharmacy Stores, Others), By Location (Rural And Urban), And By Region – Global And Regional Industry Overview, Market Intelligence, Comprehensive Analysis, Historical Data And Forecasts 2022 – 2028." into their research database. Epilepsy Therapeutics Market: Overview Epilepsy Therapeutics refers to chronic neurological disorder which causes constant and unfounded seizures. An individual suffering from Epilepsy Therapeutics tends to have seizures with no explanation. In Epilepsy Therapeutics, the brain activity becomes abnormal, resulting in recurrent seizures that are short episodes of involuntary movement, which may involve a part of the body or the entire body. The increase in the number of accidents and brain injuries and the high rate of post-traumatic Epilepsy Therapeutics (PTE) and post-traumatic seizure (PTS) occurrence in patients with brain injuries are the major factors driving the Epilepsy Therapeutics treatment market. Furthermore, innovation of new treatment products with better efficiency is expected to further drive this market. Rising number of mergers and acquisitions, new product launches, and increasing number of collaborations and partnerships are some of the latest trends that have been observed in the global Epilepsy Therapeutics market. Besides development of new drugs and treatment options, approval and launch of new products extend profitable opportunities to the Epilepsy Therapeutics treatment market players in the forecast period. In Addition, development of highly efficacious products, having less side-effects, and better outcomes are likely to propel the Epilepsy Therapeutics market Neurological disorders have become a matter of concern for medical researchers who are looking at optimizing medical treatments. Furthermore, the adoption of anti-epileptics due to increasing seizures and Epilepsy Therapeutics cases, and a rise in research and development is driving the growth of Epilepsy Therapeutics market. .However, factors such as lack of awareness about the condition some developing regions and reluctance to adopt Epilepsy Therapeutics medications in some regions are restraining the growth of the Epilepsy Therapeutics market over the upcoming years. Get a Free Sample Report with All Related Graphs & Charts (with COVID 19 Impact Analysis): Our Free Sample Report Includes: 2022 Updated Report Introduction, Overview, and In-depth industry analysis COVID-19 Pandemic Outbreak Impact Analysis Included 172 + Pages Research Report (Inclusion of Updated Research) Provide Chapter-wise guidance on Request 2022 Updated Regional Analysis with Graphical Representation of Size, Share & Trends Includes Updated List of tables & figures Updated Report Includes Top Market Players with their Business Strategy, Sales Volume, and Revenue Analysis Zion Market Research methodology Industry Dynamics: Epilepsy Therapeutics Market: Growth Drivers Active Government Support and Investments to Expedite Market Growth. Governmental initiatives to improve the healthcare sectors and higher investments in R&D is anticipated to expand at a notable growth of Epilepsy Therapeutics market during the forecast period. Rise in the number of approvals by government bodies is providing beneficial for the patients in controlling the seizures. This is projected to fuel the adoption of anticonvulsant and boost the market growth over the upcoming years. Epilepsy Therapeutics Market: Restraints Epilepsy Medicine shortage to hamper the market growth. One of the major factors restraining the growth of Epilepsy Therapeutics market during the forecast period is steep rise in medicine shortage. Patients are stockpiling these medicines as there is a shortage of drugs in pharmacies which has raised an alarm in investigating the medicine supply chain globally. This is ultimately affecting the global Epilepsy Therapeutics market as the market becomes less desirable for Epilepsy Therapeutics medications. Directly Purchase a Copy of the Report @ Global Epilepsy Therapeutics Market: Segmentation The global Epilepsy Therapeutics market is segregated based on Product, distribution channel, end-user, and region. Based on distributional channel, the global Epilepsy Therapeutics market can be segmented into hospital pharmacy, retail pharmacy, and online pharmacy. The hospital pharmacy segment is projected to dominate the global market. growing number of hospitals, along with adequate reimbursement policies provided by these settings, are some of the major factors responsible for higher growth of hospital pharmacy over the upcoming years. This is eventually responsible for the adoption of antiepileptic drugs by the hospital pharmacies globally. Based on product market has been classified into first generation Epilepsy Therapeutic second-generation Epilepsy Therapeutics and third generation Epilepsy Therapeutics. The second-generation epilepsy therapeutics segment is expected to hold a significant share of the global epilepsy therapeutics. This is due to increased penetration in the market and better effectiveness as compared to first generation Epilepsy Therapeutics. Get More Insight before [email protected] : List of Key Players of Epilepsy Therapeutics Market: BIAL - PORTELA & CA SA GlaxoSmithKline Plc Johnson & Johnson Services Inc. Novartis AG Pfizer Inc. SanofiSA Sunovion Pharmaceuticals Inc. UCB SA Zogenix Inc. Key questions answered in this report: What are the growth rate forecast and market size for Epilepsy Therapeutics Market? What are the key driving factors propelling the Epilepsy Therapeutics Market forward? What are the most important companies in the Epilepsy Therapeutics Market Industry? What segments does the Epilepsy Therapeutics Market cover? How can I receive a free copy of the Epilepsy Therapeutics Market sample report and company profiles? Report Scope: Free Brochure: Recent Developments: In January 2020, Eisai Co. Announced the launch of FYCOMPA in China for the treatment of partial-onset seizures in patients aged 12 years and older. Regional Dominance: Increasing awareness and availability. North America dominates the global market for Epilepsy Therapeutics during the forecast period. This is majorly due to higher investments in R&D, increasing awareness and availability of advanced Epilepsy Therapeutics drugs in this region. Moreover, improved healthcare facilities are driving the market for Epilepsy Therapeutics in North America during the forecast period. Asia Pacific is witnessing a significant growth in the global Epilepsy Therapeutics market over the upcoming years. Due government initiatives in the field, Increased awareness and technological advancement in field is fueling the growth of global Epilepsy Therapeutics market. Global Epilepsy Therapeutics Market is segmented as follows: Epilepsy Therapeutics Market: By Types Covered Outlook (2022-2028) Anti-Epileptic Drugs Brain Surgery Dietary Supplements Ketogenic Diet Surgical Therapies Epilepsy Therapeutics Market: By End Users Covered Outlook (2022-2028) Ambulatory Surgical Centers Hospitals& Clinics Home Care Settings Neurology Centers Epilepsy Therapeutics Market: By Products Covered Outlook (2022-2028) First Generation Epilepsy Therapeutics Second Generation Epilepsy Therapeutics Third Generation Epilepsy Therapeutics Epilepsy Therapeutics Market: By Distribution Channels Covered Outlook (2022-2028) Hospital Pharmacy Retail Pharmacy Online Pharmacy-User Epilepsy Therapeutics Market: By Region Outlook (2022-2028) North America The U.S. Canada Europe France The UK Spain Germany Italy Rest of Europe Asia Pacific China Japan India South Korea Southeast Asia Rest of Asia Pacific Latin America Brazil Mexico Rest of Latin America Middle East & Africa GCC South Africa Rest of Middle East & Africa Press Release For Epilepsy Therapeutics Market: Browse Other Related Research Reports from Zion Market Research Cannabis Cultivation Market - Global Industry Analysis : The global Cannabis Cultivation Market accrued earnings worth approximately 147.3 (USD Billion) in 2020 and is predicted to gain revenue of about 359.6 (USD Billion) by 2028, is set to record a CAGR of nearly 14.5% over the period from 2021 to 2028. 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We provide our clients not only with market statistics unveiled by avowed private publishers and public organizations but also with vogue and newest industry reports along with pre-eminent and niche company profiles. Our database of market research reports comprises a wide variety of reports from cardinal industries. Our database is been updated constantly in order to fulfill our clients with prompt and direct online access to our database. Keeping in mind the client's needs, we have included expert insights on global industries, products, and market trends in this database. Last but not the least, we make it our duty to ensure the success of clients connected to us—after all—if you do well, a little of the light shines on us . Contact Us: Zion Market Research 244 Fifth Avenue, Suite N202 New York, 10001, United States Tel: +49-322 210 92714 USA/Canada Toll Free No.1-855-465-4651 Email: [email protected] Website: Blog - SOURCE Zion Market Research

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