Last update 01 Nov 2024

Epilepsia Partialis Continua

Last update 01 Nov 2024

Basic Info

Synonyms

Chronic Progressive Epilepsia Partialis Continua, Chronic progressive epilepsia partialis continua, Chronic progressive epilepsia partialis continua (disorder)

+ [43]

Introduction

A variant of EPILEPSY characterized by continuous focal jerking of a body part over a period of hours, days, or even years without spreading to other body regions. Contractions may be aggravated by movement and are reduced, but not abolished during sleep. ELECTROENCEPHALOGRAPHY demonstrates epileptiform (spike and wave) discharges over the hemisphere opposite to the affected limb in most instances. The repetitive movements may originate from the CEREBRAL CORTEX or from subcortical structures (e.g., BRAIN STEM; BASAL GANGLIA). This condition is associated with Russian Spring and Summer encephalitis (see ENCEPHALITIS, TICK BORNE); Rasmussen syndrome (see ENCEPHALITIS); MULTIPLE SCLEROSIS; DIABETES MELLITUS; BRAIN NEOPLASMS; and CEREBROVASCULAR DISORDERS. (From Brain, 1996 April;119(pt2):393-407; Epilepsia 1993;34;Suppl 1:S29-S36; and Adams et al., Principles of Neurology, 6th ed, p319)

Drugs associated with Epilepsia Partialis Continua

Levetiracetam

Target

SV2A

Mechanism

SV2A modulators

Active Org.

Ratiopharm GmbH [+21]

Originator Org.

UCB SA

Active Indication

Epilepsia Partialis Continua [+10]

Inactive Indication

Acute repetitive seizure [+28]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date30 Nov 1999

Clinical Trials associated with Epilepsia Partialis Continua

NCT04309721 / TerminatedPhase 3IIT

Efficacy of add-on PEramPanel in Focal Motor Status Epilepticus

Randomized controlled trial on focal motor status epilepticus (SE), studying the add-on efficacy of the enteral administration of perampanel (PER) to a conventional intravenous antiepileptic drug.

Start Date02 Nov 2022

Sponsor / Collaborator

Assistance Publique des Hôpitaux de Paris SA

IRCT2016050212452N3 / CompletedNot ApplicableIIT

The effect of family-centered care on the family caregivers' burden, stress, anxiety and depression of epilepsy patients .

Start Date02 Jul 2016

Sponsor / Collaborator-

NCT03154307 / TerminatedNot ApplicableIIT

Repeated TMS at Low Frequencies to Reduce Seizure Occurrence

Perform non-invasive neuro-navigated repeated Transcranial Magnetic Stimulation (rTMS) at low frequencies (LF) with the intent to reduce the occurrence of seizures over time (long-term protocol). Seizure reduction and improvements in the quality of life in patients with epilepsy will be associated with increased cortical inhibition resulting from the LF-rTMS sessions over time. This procedure using rTMS at low frequencies (LF-rTMS) between 0.5 and 1 Hz is a safe and painless method for noninvasive focal cortical brain stimulation, which will be evaluated in its efficacy at reducing/suppressing seizures. Accordingly, we propose a clinical trial in patients with epilepsy to test whether LF-rTMS can improve seizure suppression. The location of the presumed 3D source in the brain will be stimulated for few minutes (10 to 15 min.). With the same rTMS modality, we will also perform motor threshold mapping in conjunction with its fully integrated and compatible electroencephalography (EEG) module. Up to 100 individuals 18 to 80 years with epilepsy will be enrolled.
In addition, a short-term protocol has been added to test whether LF-rTMS can reduce or suppress status epilepticus in medically refractory participants.

Start Date19 Feb 2016

Sponsor / Collaborator

Baptist Health South Florida, Inc.

[+1]

100 Clinical Results associated with Epilepsia Partialis Continua

100 Translational Medicine associated with Epilepsia Partialis Continua

0 Patents (Medical) associated with Epilepsia Partialis Continua

889

Literatures (Medical) associated with Epilepsia Partialis Continua

26 Nov 2024·Neurology

Epilepsia Partialis Continua in an Adolescent With GAD65 Antibody–Associated Encephalitis

Article

Author: Zhang, Yuying ; Ni, Guanzhong ; Zhang, Heyu ; Chen, Jingjing

21 Oct 2024·Zhonghua er ke za zhi = Chinese journal of pediatrics

[Clinical features of KCNB1 gene variation related developmental and epileptic encephalopathy].

Article

Author: Liao, J X ; Tan, Q Z ; Yang, X L ; Cheng, M M ; Liu, C H ; Wang, T ; Zhang, Y H ; Zeng, Q ; Yang, Y

Objective: To summarize the clinical features of epilepsy and (or) developmental delay associated with KCNB1 gene variants in children. Methods: A case series study was conducted on 24 children with KCNB1 gene variants associated with epilepsy and (or) developmental delay who were treated at the Children's Medical Center of Peking University First Hospital and the Department of Neurology of Shenzhen Children's Hospital from July 2015 to June 2024. The manifestations of seizures, electroencephalogram (EEG) and genetic test results of those children were analyzed. Results: All the KCNB1 gene variants were de novo, involving 20 different variation, including 15 missense variations, 3 frameshift variations and 2 nonsense variations. There were 7 novel variations. Among the 24 developmental and epileptic encephalopathy children, there were 14 boys and 10 girls. The last follow-up age ranged from 9 months to 13 years and 9 months. Seizures were present in 21 children (88%), with onset ranging from 1 month to 7 years, and 76% (16/21) began before 2 years of age. The seizure types included focal seizures in 15 children (71%), epileptic spasms, myoclonic seizures, and generalized tonic-clonic seizures in 6 children respectively, atypical absence seizures in 4 children, and myoclonic atonic seizures in 1 child. Seventeen children (81%) had a cluster of seizures and 5 had a history of focal status epilepticus with impaired consciousness. All 24 children had varying degrees of developmental delay, with 3 presenting solely developmental delay. EEG abnormalities were present in all the 21 children with seizures, including focal or multifocal discharges in 20 children, generalized discharges in 10 children, hypsarrhythmia in 2 children, and electrical status epilepticus during sleep in 3 children. Magnetic resonance imaging abnormalities were found in 5 of the 24 children. Among the 21 children with seizures, 57% (12/21) achieved seizure control. Conclusions: KCNB1 gene variants are predominantly de novo missense variation. Most affected children present with epilepsy, though some may exhibit only developmental delay. Epilepsy often begins before 2 years of age, with focal seizures being the most common type. About 80% of patients experience clustered seizures. Although most patients achieve seizure control, they still exhibit varying degrees of developmental delay, consistent with developmental epileptic encephalopathy.

01 Oct 2024·Neurological Sciences

The role of EEG and neuroimaging in the diagnosis of non-convulsive status epilepticus in Subacute Encephalopathy with Seizures in Alcoholics (SESA syndrome): a case report and overview of the literature

Review

Author: Biassoni, Erica ; Ferrari, Alessandra ; Miggino, Marco ; Roccatagliata, Luca ; Andorno, Enzo ; Bellucci, Margherita ; Resaz, Martina ; Micalizzi, Elisa ; Villani, Flavio ; Castellan, Lucio ; Porcile, Elisa

Epileptic seizures are frequently associated with liver dysfunction and alcoholism. Subacute encephalopathy with seizures in chronic alcoholics (SESA) is an underrecognized condition with peculiar clinical, EEG and neuroradiological features.We report the case of a 58-year-old man with previous alcohol use disorder (AUD) and acute-on chronic liver failure on alcohol-related cirrhosis, referred for urgent Orthotopic Liver Transplantation evaluation. The patient presented with delirium, aphasia and progressive deterioration of consciousness leading to intensive care unit admission. EEG showed slow activity with superimposed lateralized periodic discharges (LPDs) over the left temporo-occipital regions and ictal discharges with focal motor phenomena, consistent with focal status epilepticus. Antiseizure treatment with lacosamide and levetiracetam was administered with progressive improvement of consciousness.Brain MRI disclosed T2/FLAIR areas of hyperintensity in the left pulvinar and T2/FLAIR hyperintensity with corresponding DWI hyperintensity in the left hippocampal cortex, suggestive of post/peri-ictal excitotoxic changes with anatomical correspondence to focal LPDs distribution. SWI demonstrated decreased prominence of cortical veins in the left temporo-occipital region consistent with increased venous blood oxygenation in compensatory hyperperfusion.In conclusion, SESA should be suspected in the differential diagnosis of patients with AUD presenting with focal neurological deficits, seizures and focal EEG abnormalities. In this context, EEG and brain MRI represent useful tools with both diagnostic and prognostic value.

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Epilepsia Partialis Continua

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