Synonyms Chronic Motor and Vocal Tic Disorder, Combined Multiple Motor and Vocal Tic Disorder, Combined Vocal and Multiple Motor Tic Disorder + [99] |
Introduction A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79) |
Target |
Mechanism NGF modulators [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. JP |
First Approval Date31 Jul 2024 |
Target- |
Mechanism- |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. CN |
First Approval Date18 Dec 2019 |
Target |
Mechanism VMAT2 inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date11 Apr 2017 |
Start Date01 Jan 2025 |
Sponsor / Collaborator |
Start Date25 Sep 2024 |
Sponsor / Collaborator |
Start Date24 Sep 2024 |
Sponsor / Collaborator |