Synonyms ALK positive large B-cell lymphoma, ALK+ LBCL, ALK+ large B-cell lymphoma + [9] |
Introduction A usually aggressive large B-cell lymphoma characterized by the presence of monomorphic immunoblast-like neoplastic B-lymphocytes in a sinusoidal growth pattern. The neoplastic B-lymphocytes express the ALK kinase but they lack the 2;5 translocation. |
Mechanism ALK inhibitors [+3] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date26 Aug 2011 |
Target |
Mechanism CD47 inhibitors [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhasePhase 2 |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date22 Jan 2024 |
Sponsor / Collaborator |
Start Date19 Apr 2023 |
Sponsor / Collaborator |
Start Date23 Sep 2022 |
Sponsor / Collaborator |