The effect of beginning time of oral feeding on the length of hospitalization, risk of rebleeding and nutritional status of patients with upper gastrointestinal bleeding caused by peptic ulcers and erosive diseases

Start Date13 Aug 2023

Sponsor / Collaborator

Iran University of Medical Sciences & Health Services

IRCT20230410057870N1 / RecruitingPhase 2IIT

Investigating the effect of early repeated dilatations in the prevention of esophageal stricture in children with caustic substance ingestion

Start Date22 May 2023

Sponsor / Collaborator

Mashhad University of Medical Sciences

NCT05553717 / Not yet recruitingNot ApplicableIIT

Clinical Study Evaluating the Gastroprotective Effect of Carvedilol in Patients With Ischemic Heart Disease on Aspirin Therapy

The aim of this study is to investigate the possible efficacy of Carvedilol as gastroprotective agent against aspirin-induced upper gastro-intestinal complications in patients with ischemic heart disease (IHD).

Start Date01 Oct 2022

Sponsor / Collaborator

Tanta University

100 Clinical Results associated with Ulcer of esophagus

100 Translational Medicine associated with Ulcer of esophagus

0 Patents (Medical) associated with Ulcer of esophagus

1,365

Literatures (Medical) associated with Ulcer of esophagus

01 Dec 2024·Applied Microbiology and Biotechnology

Pulchinenoside B4 ameliorates oral ulcers in rats by modulating gut microbiota and metabolites

Article

Author: Yang, Shilin ; Jia, Jing ; Wang, Zhujun ; Luo, Dewei ; Ouyang, Hui ; Feng, Yulin ; Luo, Yingying ; Pei, Na ; Ji, Xiaofan ; Yan, Li

AbstractPulchinenoside B4, a natural saponin monomer from the Pulsatilla plant, plays an important role as an immunomodulator in the treatment of acute inflammation. Oral ulcer (OU) is a common ulcerative injury disease that occurs in the oral mucosa, including mucosal ulceration and abnormalities of lips and tongue. A close correlation exists between gut microbiota and circulating metabolites in patients with OU. However, the correlation between gut microbiota and serum metabolomics is not clear. Therefore, this study aimed to explore the changes in gut microbiota and metabolites in OU. The 16S ribosomal RNA (16S rRNA) gene sequencing was used to detect the changes in the composition of gut microbiota in OU rat model. Moreover, the endogenous small metabolites were explored by collecting the non-targeted serum metabolomics data. A total of 34 OU-related biomarkers were identified, mainly related to fatty acid metabolism and inflammatory pathways. The administration of B4 effectively reduced the occurrence of OU and restored the levels of multiple endogenous biomarkers and key gut microbial species to the normal level. This study demonstrated that the gut microbiota and metabolites were altered in the OU rat model, which were significantly restored to the normal level by B4, thereby showing good application prospects in the treatment of OU.Key points• The first investigating the correlation between OU and gut microbiota.• A close correlation between metabolites and gut microbiota in OU disease was successfully identified.• Pulchinenoside B4 ameliorates oral ulcers in rats by modulating gut microbiota and metabolites.

01 Oct 2024·International Journal of Toxicology

13-Week Repeated Oral Toxicity and Toxicokinetic Studies of Rabeprazole Sodium and Sodium Bicarbonate Combination in Dogs

Article

Author: Hwang, Eui-Kyung ; Nam, Kyu-Yeol ; Kim, Young-Min ; Roh, Jae Seok ; Jeon, Tae-Won ; Jung, Won Tae

The subchronic toxicity and toxicokinetics of a combination of rabeprazole sodium and sodium bicarbonate were investigated in dogs by daily oral administration for 13 consecutive weeks with a 4-week recovery period. The dose groups consisted of control (vehicles), (5 + 200), (10 + 400), and (20 + 800) mg/kg of rabeprazole sodium + sodium bicarbonate, 20 mg/kg of rabeprazole sodium only, and 800 mg/kg of sodium bicarbonate only. Esophageal ulceration accompanied by inflammation was observed in only one animal in the male (20 + 800) mg/kg rabeprazole sodium + sodium bicarbonate group. However, the severity of the ulceration was moderate, and the site of occurrence was focally extensive; thus, it was assumed to be a treatment-related effect of rabeprazole sodium + sodium bicarbonate. In the toxicokinetics component of this study, systemic exposure to rabeprazole sodium (AUClast and Cmax at Day 91) was greater in males than females, suggesting sex differences. AUClast and Cmax at Day 91 were increased compared to those on Day 1 in a dose-dependent manner. A delayed Tmax and no drug accumulation were observed after repeated dosage. In conclusion, we suggest under the conditions of this study that the no-observed-adverse-effect level (NOAEL) of the combination of rabeprazole sodium + sodium bicarbonate in male and female dogs is (10 + 400) and (20 + 800) mg/kg, respectively.

01 Oct 2024·Journal of Translational Internal Medicine

PRP improves the outcomes of autologous skin graft transplantation on the esophagus by promoting angiogenesis and inhibiting fibrosis and inflammation

Article

Author: Chai, Ningli ; Xiang, Jingyuan ; Yue, Wenyi ; Zou, Jiale ; Li, Li ; Xu, Ning ; Li, Xiao ; Wang, Pengju ; Wang, Xueting ; Chai, Mi ; Wang, Runzi ; Zhang, Lihua ; Wang, Zixin ; Li, Longsong ; Linghu, Enqiang ; Cheng, Yaxuan

AbstractBackground and ObjectivesAutologous skin graft (ASG) transplantation is a challenging approach but a promising option for patients to prevent postoperative esophageal stricture. Nonetheless, the current strategies require improvement. We aimed to investigate the effectiveness of the injection of platelet-rich plasma (PRP) before skin graft transplantation for extensive esophageal defects after endoscopic resection.MethodsStandardized complete circular endoscopic resection (5 cm in length) was performed in 27 pigs allocated into 3 groups. The artificial ulcers were treated with a fully covered esophageal stent (control group), ASG (ASG group), and submucosal injection of PRP with ASG (PRP-ASG group). Macroscopic evaluation and histological analysis of the remolded esophagus were performed 7, 14, and 28 days after surgery.ResultsThe macroscopic evaluation indicated that submucosal injection of PRP before transplantation effectively promoted the survival rate of skin grafts and decreased the rate of mucosal contraction compared with those treated with ASG or stent alone. Histological analysis of submucosal tissue showed that this modified strategy significantly promoted wound healing of reconstructed tissues by enhancing angiogenesis, facilitating collagen deposition, and decreasing inflammation and fibrogenesis.ConclusionsThese findings suggested that PRP might be used as a biological supplement to increase the esophageal skin graft survival rate and improve submucosal tissue remolding in a clinically relevant porcine model. With extremely low mucosal contraction, this novel combination strategy showed the potential to effectively prevent stenosis in extensive esophageal ulcers.

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