SummaryFamotidine is a medicine that helps people with stomach problems like gastritis and peptic ulcers. It's in a group of medicines called H2 receptor antagonists, which work by stopping the stomach from making too much acid. When there's too much acid in the stomach, people can feel a lot of pain, like heartburn or indigestion. Famotidine is really good at reducing the amount of acid in the stomach, which makes people feel better. It comes in different forms like pills and shots, so people can choose the way that works best for them. Bausch Health Americas made famotidine in 1986, and it's been used by lots of people since then. People should make sure to take famotidine as their doctor tells them to, to make sure it works properly and to avoid any side effects. |
Drug Type Small molecule drug |
Synonyms (1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamide, 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide, 3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine + [40] |
Target |
Action antagonists |
Mechanism H2 receptor antagonists(Histamine H2 receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (15 Oct 1986), |
Regulation- |
Molecular FormulaC8H15N7O2S3 |
InChIKeyXUFQPHANEAPEMJ-UHFFFAOYSA-N |
CAS Registry76824-35-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00318 | Famotidine |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Ulcer of esophagus | Australia | 08 Apr 2003 | |
Acute gastritis | Japan | 15 Mar 2000 | |
Anastomotic ulcer | Japan | 15 Mar 2000 | |
Chronic gastritis | Japan | 15 Mar 2000 | |
Esophagitis, Peptic | Japan | 15 Mar 2000 | |
Hemorrhagic gastritis | Japan | 15 Mar 2000 | |
Stomach Ulcer | Japan | 15 Mar 2000 | |
Stress ulcer | Japan | 15 Mar 2000 | |
Upper gastrointestinal hemorrhage | Japan | 15 Mar 2000 | |
Gastrointestinal Hemorrhage | China | - | 01 Jan 1996 |
Gastritis | Japan | 27 Dec 1988 | |
Peptic Ulcer | Japan | 10 Dec 1988 | |
Corneal Ulcer | United States | 15 Oct 1986 | |
Duodenal Ulcer | United States | 15 Oct 1986 | |
Esophagitis | United States | 15 Oct 1986 | |
gastric ulcer benign | United States | 15 Oct 1986 | |
Gastroesophageal Reflux | United States | 15 Oct 1986 | |
Multiple Endocrine Neoplasia | United States | 15 Oct 1986 | |
Ulcer | United States | 15 Oct 1986 | |
Zollinger-Ellison Syndrome | United States | 15 Oct 1986 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Non-erosive gastro-esophageal reflux disease | Phase 3 | Japan | 01 Sep 2005 | |
HIV Seropositivity | Phase 1 | - | 01 Jun 2008 | |
Heartburn | Phase 1 | - | 01 Aug 2006 |
Phase 2 | 72 | Adjuvant RT+Nivolumab (Single Modality De-escalation Arm (SDA)) | mzxkkjwecw = wevmsaavdq mpkxpdxcsi (rcreqooqmd, fobitbmuxr - jnzcznvtib) View more | - | 06 May 2025 | ||
Chemoradiotherapy+Nivolumab+Paclitaxel+Hydroxyurea+cisplatin+Famotidine+Diphenhydramine+Dexamethasone+5-FU (Intermediate De-escalation Arm (IDA)) | mzxkkjwecw = mvsxinqlee mpkxpdxcsi (rcreqooqmd, itwyccehmk - fmsiastkcw) View more | ||||||
Phase 2 | 80 | (Famotidine) | bbwjhmtyxi(lpmisfzzqb) = wpuvtyiqpq metswovxjs (qqomzwtpic, dqwegjdfka - ytefkrygfp) View more | - | 09 Aug 2024 | ||
Placebo (Placebo) | bbwjhmtyxi(lpmisfzzqb) = skggufztey metswovxjs (qqomzwtpic, fwcqqdvtja - lxuwutstkh) View more | ||||||
Phase 2 | 4 | (Group 1 (Study Product)) | lngeksvyrt = xlnkljiram manaujjkeh (vrpxibcuvi, ydrswtzbxf - nwwzculiin) View more | - | 09 Jul 2024 | ||
Placebo (Group 2 (Reference Therapy)) | lngeksvyrt = ssiczsawvo manaujjkeh (vrpxibcuvi, rhuwnxigej - xlmswnqelr) View more | ||||||
Phase 2 | 1 | (Treatment Group) | vcsjkkqmdm = syuhhorphv vfbxuxzewa (rzywtjfzky, hslmkzncro - xeqldcgkqx) View more | - | 20 Dec 2022 | ||
Placebo (Placebo Group) | rbfuktovoe(mlizwhhxws) = gqvypyiwql uiocxnfibc (qdaheezjid, qsiwfcllfr - idmqrfcekp) View more | ||||||
Phase 1 | 2 | vgzzorntue = yvcxceozie xotsmchldo (ddteavuepu, uwvpqijilz - qivhyresuj) View more | - | 18 Feb 2022 | |||
Phase 4 | 40 | (Omeprazole) | pgqlkvzktd = mizlglgwgx borfmnqoxe (rnleigudgx, dcrafgbufx - wmvgsqogwl) View more | - | 19 Jan 2017 | ||
(Famotidine) | pgqlkvzktd = wokhddbmso borfmnqoxe (rnleigudgx, vcoeixwnlk - yosnnasdzs) View more | ||||||
Not Applicable | 50 | otjmpuxiwh(cynzshrrax) = svyhqfxhrl pnadgevpce (mkugkkkdel ) View more | Positive | 01 Oct 2016 | |||
Placebo | otjmpuxiwh(cynzshrrax) = zrjsrvhffm pnadgevpce (mkugkkkdel ) View more | ||||||
Phase 2 | 3 | (Famotidine) | dusktfrycf = ykpivbkdvf nxtqlapzkv (xrnlcgnkxx, blvmosmejf - etnurmdhnz) View more | - | 15 Dec 2015 | ||
(Pantoprazole) | dusktfrycf = iibhocnfpm nxtqlapzkv (xrnlcgnkxx, pipiqglkoy - gzgvbzouxm) View more | ||||||
Phase 1 | 30 | (Famotidine 20 mg CT Without Water) | rkovsmnyex(aksixanizw) = obtocmjmlm allpycqbub (isdkbloenh, axdvyejnzc - vyuzigonct) View more | - | 09 Dec 2015 | ||
FCT+Famotidine (Famotidine 20 mg FCT With Water) | rkovsmnyex(aksixanizw) = dbkjjfdqim allpycqbub (isdkbloenh, uutnsnlqon - gdtlmhwijx) View more | ||||||
Not Applicable | 15 | Interleukin-2 18 Million IU/M2 | ebdfxuogbg(speycdkrwm) = 12 morugluzfi (eznniembgy ) View more | Positive | 07 Nov 2013 |