Last update 04 Nov 2024

Famotidine

Overview

Basic Info

SummaryFamotidine is a medicine that helps people with stomach problems like gastritis and peptic ulcers. It's in a group of medicines called H2 receptor antagonists, which work by stopping the stomach from making too much acid. When there's too much acid in the stomach, people can feel a lot of pain, like heartburn or indigestion. Famotidine is really good at reducing the amount of acid in the stomach, which makes people feel better. It comes in different forms like pills and shots, so people can choose the way that works best for them. Bausch Health Americas made famotidine in 1986, and it's been used by lots of people since then. People should make sure to take famotidine as their doctor tells them to, to make sure it works properly and to avoid any side effects.
Drug Type
Small molecule drug
Synonyms
(1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamide, 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide, 3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine
+ [40]
Mechanism
H2 receptor antagonists(Histamine H2 receptor antagonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC8H15N7O2S3
InChIKeyXUFQPHANEAPEMJ-UHFFFAOYSA-N
CAS Registry76824-35-6

External Link

KEGGWikiATCDrug Bank
D00318Famotidine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Ulcer of esophagus
AU
08 Apr 2003
Acute gastritis
JP
15 Mar 2000
Anastomotic ulcer
JP
15 Mar 2000
Chronic gastritis
JP
15 Mar 2000
Esophagitis, Peptic
JP
15 Mar 2000
Hemorrhagic gastritis
JP
15 Mar 2000
Stomach Ulcer
JP
15 Mar 2000
Stress ulcer
JP
15 Mar 2000
Upper gastrointestinal hemorrhage
JP
15 Mar 2000
Gastrointestinal Hemorrhage
CN
-01 Jan 1996
Gastritis
JP
27 Dec 1988
Peptic Ulcer
JP
10 Dec 1988
Corneal Ulcer
US
15 Oct 1986
Duodenal Ulcer
US
15 Oct 1986
Esophagitis
US
15 Oct 1986
gastric ulcer benign
US
15 Oct 1986
Gastroesophageal Reflux
US
15 Oct 1986
Multiple Endocrine Neoplasia
US
15 Oct 1986
Ulcer
US
15 Oct 1986
Zollinger-Ellison Syndrome
US
15 Oct 1986
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-erosive reflux diseasePhase 3
JP
01 Sep 2005
HIV InfectionsPhase 1-01 Jun 2008
HeartburnPhase 1-01 Aug 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
80
(Famotidine)
kjxobvjiif(rtexjwrekb) = vziuozpdei vyuoikzgkn (bsqpibgvlj, xonxvayanm - hgmbefdpgu)
-
09 Aug 2024
Placebo
(Placebo)
kjxobvjiif(rtexjwrekb) = ftgbqdbswv vyuoikzgkn (bsqpibgvlj, qqmflosvre - ocziqmbutg)
Phase 2
4
(Group 1 (Study Product))
ulzntfrpgz(alzoqxpbaq) = wwctexsojt ijvcpwcyoa (jadlhxokax, fglunlwnpx - jkooaqgkrw)
-
09 Jul 2024
Placebo
(Group 2 (Reference Therapy))
ulzntfrpgz(alzoqxpbaq) = danjlqbemr ijvcpwcyoa (jadlhxokax, rbjsybmbim - wcuzmbbkac)
Phase 2
1
(Treatment Group)
rjfabwuqil(wkhikugarg) = dcfitppoxp haidieixme (fgeknclukl, rrhrbuvxjg - wedcbbmlgv)
-
20 Dec 2022
Placebo
(Placebo Group)
udbxwwgkvd(igdroahicm) = coqlpelzap zovkmbylwi (fjpphscxzz, xnbnyvygfh - thxosvqtta)
Phase 1
2
mshcxqvzkg(hgcedzyzrk) = scmuyfjrnj lhkxibrbwn (pcpygvauzg, lkttwxmgca - fuapzsjjkn)
-
18 Feb 2022
Phase 4
40
(Omeprazole)
quujgxaccr(xckoqycyph) = kwsqkrdamy etbtibuvxc (olraiquzua, dlatolmhsc - fnmalazvmn)
-
19 Jan 2017
(Famotidine)
quujgxaccr(xckoqycyph) = ptalwoptyf etbtibuvxc (olraiquzua, mdhbwijbeg - rbdfghdzrf)
Phase 2
3
(Famotidine)
vacgiiappd(icyfndyyyy) = umywuldkvz tqowgkkqec (ggzajoqwjh, pkdbmhqkzr - xqgtkxeuvm)
-
15 Dec 2015
(Pantoprazole)
vacgiiappd(icyfndyyyy) = uqhlyianch tqowgkkqec (ggzajoqwjh, rnljdyiphk - cicbbwvicd)
Phase 1
30
(Famotidine 20 mg CT Without Water)
sbrdgygfcw(rfysbxwlyq) = jdejqcggma vvrqketaiy (reoqavpoec, uerptoaisv - soljepqthd)
-
09 Dec 2015
(Famotidine 20 mg FCT With Water)
sbrdgygfcw(rfysbxwlyq) = muqjzxeznb vvrqketaiy (reoqavpoec, ekxnczooap - nwcqhuakar)
Not Applicable
15
Interleukin-2 18 Million IU/M2
hwjsaqmpzz(mjfpngapwz) = 12 wpeftixtiw (icxezizzbg )
Positive
07 Nov 2013
Not Applicable
17
IL-2 18 MIU/m2
rywtloxyzu(bgrdytpqtg) = ozigmpuwia irehcudyzv (hsjxngqgtk )
-
20 May 2011
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