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Last update 23 Jan 2025

Leukemoid Reaction

Last update 23 Jan 2025

Basic Info

Synonyms

LEUKAEMOID REACTION, LEUKEMOID REACTION, Leukaemoid reaction

+ [23]

Introduction

A peripheral blood picture resembling that of leukemia or indistinguishable from it on the basis of morphologic appearance alone. (Dorland, 27th ed)

Drugs associated with Leukemoid Reaction

MK-2206

Target

Akt

Mechanism

Akt inhibitors

Active Org.

National Cancer Institute [+2]

Originator Org.

Merck Sharp & Dohme Corp.

Active Indication

Recurrent Prostate Carcinoma [+5]

Inactive Indication

Acute Erythroblastic Leukemia [+128]

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with Leukemoid Reaction

NCT05702645

/ RecruitingNot ApplicableIIT

Chronic Health Conditions in Down Syndrome-Associated Acute Leukemia: The Down Syndrome Phenotyping Acute Leukemia Study in Survivors (DS-PALS Survivors)

This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it is unclear of their risk for long-term effects of cancer treatment. By learning more about the factors that may contribute to chronic health conditions and long-term effects after treatment for leukemia in persons with Down syndrome, clinical practice guidelines for survivorship care can be developed to help improve their quality-of-life.

Start Date12 Jun 2023

Sponsor / Collaborator

The Children's Oncology Group Foundation, Inc.

NCT05776719

/ RecruitingNot ApplicableIIT

Efficacy of Virtual Warrior Renew Therapy for Veterans Who Experienced Military Sexual Trauma

Group treatments may be helpful for Veterans who have experienced military sexual trauma (MST). By doing this study, the investigators hope to learn if two different groups: Warrior Renew and Health & Wellness are effective in reducing mental health symptoms in Veterans who have experienced MST and if either is more effective than the other. Participation in this research will last about 16 weeks.

Start Date15 May 2023

Sponsor / Collaborator

Seattle Institute for Biomedical & Clinical Research

[+1]

NCT04726241

/ RecruitingPhase 1/2IIT

Pediatric Acute Leukemia (PedAL) Screening Trial - Developing New Therapies for Relapsed Leukemias

This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.

Start Date18 Apr 2022

Sponsor / Collaborator

National Cancer Institute

[+1]

100 Clinical Results associated with Leukemoid Reaction

100 Translational Medicine associated with Leukemoid Reaction

0 Patents (Medical) associated with Leukemoid Reaction

1,742

Literatures (Medical) associated with Leukemoid Reaction

01 Jan 2025·Neurosurgery

Optimal Timing of Microsurgical Treatment for Ruptured Arteriovenous Malformations: A Systematic Review and Meta-Analysis

Review

Author: Spiotta, Alejandro M ; Orscelik, Atakan ; Assad, Salman ; Elawady, Sameh Samir ; Sowlat, Mohamed Mahdi ; Musmar, Basel ; Matsukawa, Hidetoshi ; Ismail, Mustafa ; Cunningham, Conor

BACKGROUND AND OBJECTIVES:The timing of microsurgical treatment (MST) for ruptured brain arteriovenous malformations (bAVM) is a contentious issue in the literature. This study aimed to investigate the impact of MST timing on outcomes in patients with ruptured bAVMs, considering MST with and without preoperative endovascular treatment (EVT).METHOD:Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, a comprehensive search was conducted across multiple databases, yielding 15 studies meeting the inclusion criteria. The timing was defined as the duration from the rupture of bAVM to the MST. The patients were divided into 4 different groups based on MST timing: <48 hours, <1 week, <2 weeks, and <1 month. The primary outcome was favorable outcome defined as a modified Rankin Scale score of 0 to 2 or a Glasgow Outcome Scale score of 4 to 5 in the last clinical follow-up. Secondary outcomes included periprocedural mortality and complete excision.RESULTS:MST time >48 hours were associated with a significantly higher favorable outcome rate (odds ratio: 9.71, 95% Cl: 3.09-30.57, P < .01) and a lower mortality rate (OR: 0.15, 95% Cl: 0.02-0.88, P = .04) compared with MST timing ≤48 hours. After exclusion of patients who underwent MST with preoperative EVT, MST time >48 hours had a significantly higher rate of favorable outcome (OR: 9.39, 95% CI: 2.53-34.89, P < .01).CONCLUSION:This meta-analysis suggests that delayed surgical intervention beyond 48 hours may be associated with improved favorable outcomes in patients who underwent MST with and without preoperative EVT for ruptured bAVMs.

01 Jan 2025·Journal of Women's Health

Electronic Health Record Concordance with Survey-Reported Military Sexual Trauma Among Younger Veterans: Associations with Health Care Utilization and Mental Health Diagnoses

Article

Author: Haskell, Sally G. ; Burg, Matthew M. ; Deviva, Jason C. ; Skanderson, Melissa ; Gaffey, Allison E. ; Bastian, Lori A. ; Brandt, Cynthia A.

Introduction: Military sexual trauma (MST) is more common among post-9/11 Veterans and women versus older Veterans and men. Despite mandatory screening, the concordance of electronic health record (EHR) documentation and survey-reported MST, and associations with health care utilization and mental health diagnoses, are unknown for this younger group. Materials and Methods: Veterans' Health Administration (VHA) EHR (2001-2021) were merged with data from the observational, nationwide WomenVeterans Cohort Study (collected 2016-2020, n = 1058; 51% women). Experiencing MST was defined as positive endorsement of sexual harassment and/or assault. From the EHR, we derived Veterans' number of primary care and mental health visits in the initial two years of VHA care and diagnoses of posttraumatic stress disorder (PTSD), depression, and anxiety. First, the concordance of EHR MST screening and survey-reported MST was compared. Next, multivariate analyses tested the cross-sectional associations of EHR screening and survey-reported MST with Veterans' health care utilization, and compared the likelihood of PTSD, depression, and anxiety diagnoses by MST group, while covarying demographics and service-related characteristics. With few MST cases among men, multivariate analyses were only pursued for women. Results: Overall, 29% of women and 2% of men screened positive for MST in the EHR, but 64% of women and 9% of men had survey-reported MST. Primary care utilization was similar between women with concordant, positive MST reports in the EHR and survey versus those with survey-reported MST only. Women with survey-reported MST only were less likely to have a PTSD or depression diagnosis than those with concordant, positive MST reports. There was no group difference in women's likelihood of anxiety. Conclusions: EHR MST documentation is discordant for many post-9/11 Veterans-both for men and women. Improving MST screening and better supporting MST disclosure are each critical to provide appropriate and timely care for younger Veterans, particularly women.

31 Dec 2024·European Journal of Psychotraumatology

Defining military sexual trauma: establishing parameters and perspectives

Author: Campbell, Gavin ; Wood, Abigail ; Godier-McBard, Lauren ; Murphy, Dominic ; Herriott, Charlotte

Background: The term military sexual trauma [MST] is increasingly used to describe instances of sexual harassment/assault that occur between serving personnel during military service. However, in the absence of a clear universal definition, MST is an increasingly contested term, with confusion about its scope, application to differing jurisdictions and implications for responses and treatment.Objective: This editorial provides a universal definition of MST, decoupled from any national system or framework.Method: Drawing on existing international evidence about the nature and impact of MST.Results and Conclusion: We argue that MST terminology provides a unique framing which recognises the institutional nature of MST victimisation and situates the context, behaviours, and impact on a continuum of violence.

News (Medical) associated with Leukemoid Reaction

08 Nov 2022

·www.prnewswire.com

THE VETERANS CONSORTIUM PRO BONO PROGRAM RECEIVES A GRANT FROM THE JOHN AND DARIA BARRY FOUNDATION

WASHINGTON, Nov. 8, 2022 /PRNewswire/ -- The Veterans Consortium (TVC) is pleased to announce that the John and Daria Barry Foundation has awarded a three-year long grant to fund our Women Veterans Legal Assistance Program (WVLAP). WVLAP is the only national program that focuses exclusively on the unique legal needs and challenges of women veterans. Our program ensures that women veterans are represented by highly trained female volunteer attorneys, who are equipped to assist their clients in a culturally competent and trauma informed manner. With the generous support of the Barry Foundation, TVC will expand its scope in assisting women veterans, nationwide, with claims for VA disability compensation for conditions related to military sexual trauma (MST), and claims for women specific issues, such as reproductive health. Continue Reading There are currently over two million U.S. military female veterans, accounting for 15 percent of the veteran population. Historically, claims for service-connected disability and compensation for post-traumatic stress disorder (PTSD) based on MST have been disproportionately denied. In 2021, VA's Office of the Inspector General (OIG) found that more than half of MST-related claims were improperly processed, putting these women at increased risk for depression, substance abuse, PTSD, suicide, and homelessness. Women veterans are four times more likely to become homeless than their male counterparts and are the fastest-growing group in the homeless population. The Barry Foundation's commitment to TVC's work will honor the service of our women veterans. Tweet this The John and Daria Barry Foundation is committed to improving opportunities for underserved communities, with a focus on veterans, education, and the environment. John and Daria Barry's commitment to TVC's work will honor the service of our women veterans and cast a spotlight on the unique legal needs they face. "This generous grant will allow us to increase our reach and impact by adding additional staff to assist with outreach, training & education, and support of the legal advice and Referral clinic. The three-year funding allows for continuity of the program and quality of service. We're very grateful to Morgan Barry, Esq., a member of TVC's National Volunteer Corps and an Associate at Blank Rome, for bringing our mission to the attention of the Barry Foundation," Stephen Jordon, TVC Executive Director. The Veterans Consortium Pro Bono Program (TVC) is a leading national 501(c)(3) charity providing free legal services for veterans in need. For more information about TVC, how to get involved, how to support the organization and our national outreach initiatives please visit our website, or contact TVC via email at [email protected]. SOURCE The Veterans Consortium

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