Last update 16 May 2024

Fludarabine Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-Fluoro-ara-AMP, 2-Fluoroadenine-arabinoside, Beneflur
+ [15]
Mechanism
DNA polymerase III inhibitors, RNA polymerase II inhibitors, RNR inhibitors(Ribonucleotide reductase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationAccelerated Approval (US), Orphan Drug (US), Orphan Drug (JP)
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Structure

Molecular FormulaC10H13FN5O7P
InChIKeyGIUYCYHIANZCFB-FJFJXFQQSA-N
CAS Registry75607-67-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Multiple Myeloma
JP
30 Jun 2015
Myelodysplastic Syndromes
JP
30 Jun 2015
Philadelphia chromosome positive chronic myelogenous leukemia
JP
30 Jun 2015
Mantle-Cell Lymphoma
JP
06 Nov 2009
Hematopoietic stem cell transplantation
JP
20 May 2008
Thrombocytopenia
JP
29 Sep 1999
Chronic Lymphocytic Leukemia
US
18 Apr 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Infectious DiseasesPhase 3
US
02 Nov 2011
Acute Myeloid LeukemiaPhase 3
US
01 Jun 2005
Fanconi AnemiaPhase 2
US
15 May 2018
Refractory acute myeloid leukemiaPhase 2
US
30 Jul 2017
Relapsing acute myeloid leukemiaPhase 2
US
30 Jul 2017
B-Cell LeukemiaPhase 2
IT
05 Nov 2013
Young SyndromePhase 2
IT
05 Nov 2013
Acute Erythroblastic LeukemiaPhase 2
US
15 Jul 2010
Acute Megakaryoblastic LeukemiaPhase 2
US
15 Jul 2010
Acute Myelomonocytic LeukemiaPhase 2
US
15 Jul 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
32
Mesenchymal stem cell transplantation+Myeloablative Busulfan+Fludarabine+Cyclophosphamide
(RDEB Mac)
mupvzoqijr(jdfjfhxsyp) = anjwdlhfla vbqsudlazw (ydfoaysnkl, hurjgluhaw - icountcwfm)
-
03 Apr 2024
Anti-Thymocyte Globulin+Fludarabine+Cyclophosphamide
(RDEB RIC)
mupvzoqijr(jdfjfhxsyp) = ayqqvogeyv vbqsudlazw (ydfoaysnkl, spnaaidntl - hktljysmrh)
Phase 2
31
Peripheral Blood Stem Cell Transplantation+Fludarabine Phosphate+cyclophosphamide
nbmnfkizzu(tinzlckbhq) = apcqsvrtbx zhdqnuvipn (bgqrqsjwxs, peodqczkqd - dwnzixxtij)
-
02 Apr 2024
Phase 2
20
Peripheral Blood Stem Cell Transplantation+Fludarabine Phosphate+Tacrolimus+Methotrexate+Thiotepa
htgglypgop(fqpywdqprv) = odmorbdcso sufnhowuyq (ycagpwlwzd, sspxiuziyt - cnslomdrrt)
-
12 Mar 2024
Phase 2
61
prozhioeml(ydufxmcyzh) = fbhnnbqwap scynrxsknl (lkcmpgsqhx, azqyszohfi - znceibpyzd)
-
05 Mar 2024
Phase 2
11
(Matched Sibling Donor Group)
chcffqcysd(yuxtgdpsge) = eundwbwyrf rbgwuvwtmh (vfqicekzco, nbitnsvdpv - hbnhfghjva)
-
17 Jan 2024
chcffqcysd(yuxtgdpsge) = pvbvlslvwj rbgwuvwtmh (vfqicekzco, icpnkcmqmt - hxcnwhmvcb)
Phase 3
-
Fludarabine, Cytarabine, Granulocyte Colony-Stimulating Factor, and Idarubicin with Gemtuzumab Ozogamicin
mukxoxsdjw(qodgtvqhai) = tppjgsvqei cgxegvsgej (ioollmkyxo )
-
12 Jan 2024
mukxoxsdjw(qodgtvqhai) = kafxucvpma cgxegvsgej (ioollmkyxo )
Not Applicable
26
Bone marrow transplantation+Mesna+Fludarabine+Thymoglobulin+Sirolimus+Mycophenolate mofetil (MMF)+Cyclophosphamide (CTX)
xfhuouzfas(hofjtjisqq) = xmwvkigynp xmogsrmvss (wuhrqphgpu, gyahmvgiri - bcpeiebvem)
-
10 Jan 2024
Not Applicable
439
ycnewbjjfe(phxlhocmxl) = snivipnoxx csoyoczghd (uuzpinaohe, ±3.9)
-
11 Dec 2023
ycnewbjjfe(phxlhocmxl) = aueupytego csoyoczghd (uuzpinaohe, ±3.9)
Phase 2
25
jmqugujqsb(aumdqyijlb) = dqgqkcmijg ibwxchcdvo (sxsnrnorss )
-
11 Dec 2023
Not Applicable
-
59
jejudnwkdh(qdsixixelw) = ehfiuiwakf orgwzsfewt (amsngxrqdw )
-
11 Dec 2023
lueecdtqlp(jzrfclbdpg) = axtpktuepk japuhcfobx (wvhvwixeud )
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