Last update 09 Dec 2024
Luliconazole
Last update 09 Dec 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms Luconac Solution, Luliconazole (JAN/USAN/INN), Lulifin + [12] |
Target |
Mechanism fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date JP (11 Apr 2005), |
Regulation- |
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Structure
Molecular FormulaC14H9Cl2N3S2 |
InChIKeyYTAOBBFIOAEMLL-REQDGWNSSA-N |
CAS Registry187164-19-8 |
Related
15
Clinical Trials associated with LuliconazoleEfficacy Evaluation of Loaded Nanostructured Lipid Carriers (NLC) with Luliconazole in Treatment-Resistant Dermatophytosis
A Comparative study to evaluate the efficacy and safety of topical Luliconazole versus topical Ciclopirox olamine among patients with Tinea corporis/cruris - NIL
A randomized study to evaluate and compare the efficacy of emollient versus topical luliconazole in the maintenance of remission of recurrent dermatophytosis after adequate systemic treatment.
100 Clinical Results associated with Luliconazole
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100 Translational Medicine associated with Luliconazole
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100 Patents (Medical) associated with Luliconazole
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195
Literatures (Medical) associated with Luliconazole01 Nov 2024Current drug research reviews
Assessing the Efficacy of Berberine Hydrochloride-loaded Transethosomal
Gel System in Treating Dermatophytosis Caused by Trichophyton rubrum
in ex-vivo, in-vitro and in-vivo Models
Article
Author: Mishra, Koushlesh Kumar ; Tiwari, Abhishek ; Singh, Sunil ; Kaur, Chanchal Deep ; Sharma, Ajay ; Tiwari, Varsha
Background::
Dermatophytosis is the most common dermatological disorder worldwide.
Many drugs are available in the market for the treatment of dermatophytosis, but they have
had limited success due to the stratum corneum barrier, antifungal resistance, drug permeation,
drug retention in skin layers, etc. Thus, there is a constant need for new topical compounds that
are effective against dermatophytosis. Berberine-hydrochloride is an attractive candidate to become
an antifungal drug, and by using nanotechnology, it achieves deeper penetration in skin layers
with enhanced permeability through the stratum corneum.
Methods::
In this study, we developed an oleic acid-containing berberine-hydrochloride-loaded
transethosomal gel for effective treatment of dermatophytosis by Trichophyton rubrum. Berberine-
hydrochloride-loaded transethosomal gels were fabricated using the hot homogenization
method, followed by the incorporation of transethosomes into the gel-based system using carbopol
934. Transethosomal gel was characterized by physicochemical properties, in vitro drug release,
ex-vivo permeation studies, CLSM visualization, antifungal activity, histopathological evaluation,
and dermatokinetic study.
Results::
Berberine-hydrochloride-loaded transethosomes seemed to be spherical and found in a
range between 200-300 nm. Berberine-hydrochloride-loaded transethosomal gel formulation also
exhibited controlled ex-vivo permeation of berberine-hydrochloride over 24 hr through excised rat
skin, and CLSM confirmed deeper penetration into skin layers. The in vivo study revealed that
transethosomal gel had a healing effect on the skin of Wistar rats infected with Trichophyton
rubrum and was better than luliconazole cream. The histopathological evaluation confirmed its
safety, and the dermatokinetic study showed transethosomal gel superiority over marketed cream.
Conclusion::
Therefore, the incorporation of berberine hydrochloride-loaded transethosomal
nanosystems into the gel has the potential to enhance antifungal activity and permeation through
transdermal drug delivery.
18 Oct 2024Cureus Journal of Medical Science
Deep Dermal Dilemma: A Case Report on Majocchi’s Granuloma After Topical Steroid Use
Article
Author: Cinna T Durai, Priya ; Veerakumar, Renuka Devi ; Narasimhan, Murali ; Murthy, Aravind Baskar
Majocchi's granuloma represents a unique dermatological entity characterized by the invasion of dermatophytes into the dermis and subcutaneous tissue, typically following trauma or topical corticosteroids, most commonly caused by Trichophyton rubrum. The unrestrained use of over-the-counter topical steroids has led to the rise of Majocchi's granuloma in the past few years. A 57-year-old male presented with complaints of itchy skin lesions over his right ankle for 20 days. There was a history of over-the-counter topical steroid application, following which the lesions exacerbated. Clinical examination showed multiple ill-defined erythematous nodules, 2-3 cm in size, with serosanguinous discharge associated with right ankle swelling. A single annular hyperpigmented scaly patch was also noted over the right leg below the knee. Potassium hydroxide (KOH) examination was positive for fungal hyphae. Histopathological examination (HPE) of the nodule showed features suggestive of Majocchi's granuloma. Fungal culture was performed, which showed growth of Trichophyton rubrum. The patient was started on oral terbinafine 250 mg once daily and topical luliconazole cream twice daily topical application, which resolved the lesions in three weeks, but the patient was advised to continue the treatment for a total duration of two months.
01 Sep 2024Naunyn-Schmiedeberg's archives of pharmacology
Polymeric micelle gel with luliconazole: in vivo efficacy against cutaneous candidiasis in Wistar rats
Article
Author: Narang, Raj Kumar ; Singh, Gurmeet
The objective of this research was focused on the design and development of luliconazole-loaded polymeric micelle hydrogel (LUL-PM-CHG) using quality by design (QbD) principle to improve the penetration and retention of LUL in the skin. The optimization of the formulation involved the utilization of a Box-Behnken design with three factors and three levels. The impact of specific formulation variables, namely the ratio of poloxamer P123 and F127, sonication time, and the quantity of drug, was investigated in terms of particle size, micellar incorporation efficiency, and polydispersity index. The LUL-loaded P123/F127 mixed micelles involved the thin film hydration method for thin preparation. The characteristics of optimized formulation include a particle size of 226 ± 8.52 nm, a polydispersity index (PDI) of 0.153 ± 0.002, a zeta potential (ZP) of 30.15 ± 2.32 mV, and a micellar incorporation efficiency (MIE) of 88.38 ± 3.84%. In vitro release studies indicated a sustained release of LUL-PM-CHG for a duration of up to 8 h. The MIC, GI50, and GI90 of different formulations on Candida albicans were determined using both the microtiter broth dilution method and the plate method and showed that LUL-PM-CHG exhibited the highest antifungal activity compared to the other formulations, with MIC values of 3.25 ± 0.19 ng/mL, GI50 values of 37.11 ± 2.89, and GI90 values of 94.98 ± 3.41 The study also measured the % of inhibition activity and the generation of intracellular reactive oxygen species (ROS) using flow cytometry. LUL-PM-CHG showed the highest percentage of inhibition (75.5%) and ROS production (MFI-140951), indicating its enhanced activity compared to LUL-CHG and LUL. Fungal infection was induced in Wistar rats using immunosuppressant's treatment followed by exposure to C. albicans. Finally, in vivo fungal scaling and histopathological studies indicated a reduction in fungal infection in Wistar rat skin after treatment. The obtained results suggested that LUL-PM can serve as a promising formulation to enhance luliconazole antifungal activity and increase patient compliance.
1
News (Medical) associated with Luliconazole10 Sep 2015
First in Class
100 Deals associated with Luliconazole
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External Link
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D01980 | Luliconazole |
R&D Status
Approved
10 top approved records. to view more data
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| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Tinea Manus | US | 20 Feb 2018 | |
| Onychomycosis | JP | 22 Jan 2016 | |
| Candidiasis, Cutaneous | CN | 27 Jun 2012 | |
| Mycoses | KR | 01 Feb 2010 | |
| Tinea corporis | JP | 31 Jul 2005 | |
| tinea cruris | JP | 31 Jul 2005 | |
| Tinea Pedis | JP | 31 Jul 2005 | |
| Candidiasis | JP | 11 Apr 2005 | |
| Tinea | JP | 11 Apr 2005 | |
| Tinea Versicolor | JP | 11 Apr 2005 |
Developing
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Candidiasis, Chronic Mucocutaneous | Discovery | US | 11 Jan 2011 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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Phase 4 | 20 | ezuoampbsi(oeuihlsbar) = fsnxinadgc gwwxqzulil (ppeofunxqq, llywqdgims - wztlhdjday) View more | - | 27 Nov 2019 | |||
Phase 4 | 30 | (Tinea Pedis) | wanapygeau(kywcxvhoqr) = cokzhjpvsh nltbqesvxo (ygynvlnjcl, lgakwmkhzc - vpozyhqhse) View more | - | 27 Nov 2019 | ||
(Tinea Cruris) | mbzekdglcm(vllibpesis) = zgmudtlequ pokdngfmdn (sbbosnecsd, bhrpcnzfzk - ghkydzkpyv) View more | ||||||
Phase 4 | 75 | (Luliconazole Cream 1%) | gyzwcypvlh(hxrzdrdjtu) = bxzmsvrazp fqogjuibyn (cmzdwwzxku, ypppvtzyjh - fkgborypyl) View more | - | 27 Nov 2019 | ||
Vehicle Cream (Vehicle Cream) | gyzwcypvlh(hxrzdrdjtu) = jddymkfpxc fqogjuibyn (cmzdwwzxku, mqzvuxnhnv - hrgowcbquh) View more |
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