Olfactory Nerve Diseases

--Board expansion marks an important strategic step as Triveni advances precision I&I pipeline-- WALTHAM, Mass., Dec. 13, 2023 /PRNewswire/ -- Triveni Bio Inc., a biotech company pioneering a genetics-informed precision medicine approach to develop functional antibodies for the treatment of I&I disorders, today announced the appointment of Jeff Albers as Chair of the Board and Allison Luo, M.D., to the Board of Directors. "Jeff and Allison's appointment comes at a pivotal moment for the company on the heels of a successful series A financing," said Vishal Patel, Ph.D., Chief Executive Officer, Triveni Bio. "They each bring a wealth of operational experience and direct knowledge of the I&I landscape. Jeff and Allison's collective expertise will support advancement of TRIV-509 into the clinic in 2025 and broader buildout of Triveni's novel antibody pipeline for multiple diseases with high medical need." Jeff Albers is an accomplished leader with over 25 years in the biopharmaceutical industry. As the former CEO of Blueprint Medicines, he scaled the company from a research-stage organization to a global precision medicine leader. Jeff was responsible for two U.S. Food and Drug Administration (FDA) approvals. Jeff currently is board chair of Blueprint Medicines, and on the board of directors at Kymera Therapeutics and Spyre Therapeutics. He earned a B.S. from Indiana University as well as an M.B.A. and J.D. from Georgetown University. "I am honored to assume the role of Board Chair at Triveni and to work alongside this committed team," said Albers. "Triveni is backed by a syndicate of top tier investors who share the company's vision to advance novel I&I therapies based on human genetics, best-in-class antibody design, and precision medicine." Allison Luo has over two decades of clinical development expertise in the biopharmaceutical industry – most recently serving as the Chief Medical Officer of Prometheus Biosciences. Dr. Luo was previously Chief Medical Officer of Escalier and Oppilan (Ventyx), Senior Vice President of Clinical Development for Gastroenterology at Progenity (Biora), and Vice President of Clinical Development at Ophthotech (Iveric Bio), where she successfully completed two Phase 3 studies. She also worked at Bristol Myers Squibb, overseeing programs for Orencia® and eldelumab. Dr. Luo earned a B.S. in biochemistry and M.D. from Northwestern University, followed by a fellowship in drug development at Abbott Laboratories (AbbVie). "This is an exciting opportunity to be part of a precision medicines company. We know that the probability of success in drugging a target is higher when genetic linkage is present," said Dr. Luo. "TRIV-509 has the potential to be a best- and first-in class therapy for atopic dermatitis via its unique mechanism that directly impacts barrier dysfunction, inflammation, and itch as well as for other indications." Triveni's Board of Directors also includes: Vishal Patel, Ph.D., Chief Executive Officer; Jean-François Formela, M.D., Partner, Atlas Venture; Raymond J. Kelleher, M.D., Ph.D., Managing Director, Cormorant Asset Management; Jonathan Mandelbaum, Ph.D., Vice President, OrbiMed; Tillman Gerngross, Ph.D., Co-founder and Executive Chairman of the Board, Adimab; and Ram Aiyar, Ph.D., M.B.A., Chief Executive Officer and President, Korro Bio. About Triveni Bio Triveni Bio is a biotech company pioneering a genetics-informed precision medicine approach to develop functional antibodies for the treatment of I&I disorders. The company's approach establishes proof-of-concept at the earliest stages of drug development. Through a strong understanding of genetics and mechanistic biology, our pipeline is powered for indication expansion where we know we can have the most impact. To learn more, visit . SOURCE Triveni Bio

SAN DIEGO--(BUSINESS WIRE)-- Pipeline Therapeutics, Inc. (the Company) announced today that it has changed its name to Contineum Therapeutics, Inc. (Contineum). The Company chose Contineum (pronounced "Con-tin-E-um") to represent its continuous dedication to the pursuit of scientific discovery and cutting-edge solutions designed to benefit patients. Contineum is focused on discovering and developing novel, oral small molecule therapies for neuroscience, inflammation and immunology (NI&I) indications with high unmet need. "Our goal is to create precision small molecules that can alter the course of clinical impairment in neurology, inflammation and immunology diseases. The Company’s recent expansion into fibrotic diseases expands the potential of our pipeline and this name change is an exciting reflection of that progress,” said Carmine Stengone, CEO of Contineum. “We are building a nimble biopharmaceutical company with multiple clinical indications, large potential market opportunities such as IPF and multiple sclerosis, and a discovery platform targeting clinically validated mechanisms like LPA1 and M1 aimed at modulating innate pathways to restore function in NI&I indications. We look forward to continuing to grow Contineum under our new moniker to develop product candidates to improve patients’ lives.” In conjunction with the corporate name change, the Company will have a new website address: . About Contineum Therapeutics Contineum Therapeutics is a clinical stage biopharmaceutical company focused on discovering and developing novel, oral small molecule therapies for NI&I indications with high unmet need. Contineum is focused on targeting biological pathways associated with specific clinical impairments, that the Company believes, once modulated, can demonstrably impact the course of disease. The Company has a pipeline of internally-developed programs to address multiple NI&I disorders, including PIPE-791, an LPA1 receptor antagonist, in Phase 1 for idiopathic pulmonary fibrosis and progressive multiple sclerosis, and PIPE-307, a potentially first-in-class selective inhibitor of the M1 receptor in Phase 2 for relapse-remitting multiple sclerosis and with a Phase 2 for depression planned to initiate in mid-2024. Contineum is developing PIPE-307 in collaboration with Johnson & Johnson Innovative Medicines. In addition, Contineum is advancing discovery efforts targeting other NI&I indications where the Company’s internally-discovered molecules and approach may have therapeutic potential. Contineum is headquartered in San Diego, CA. For more information, please visit or engage with us on LinkedIn.

--Series A proceeds fund advancement of the company's lead program through clinical proof-of-concept study in atopic dermatitis and progression of broader precision I&I pipeline-- --Pipeline strategy to prosecute genetically validated targets linked to monogenic diseases with functional antibodies for precision populations across multiple indications-- WALTHAM, Mass., Oct. 26, 2023 /PRNewswire/ -- Triveni Bio Inc., a biotech company pioneering a genetics-informed precision medicine approach to develop functional antibodies for the treatment of I&I disorders, today announced a $92 million series A financing co-led by Atlas Venture and Cormorant Asset Management, with participation from OrbiMed, the private equity business of Viking Global Investors, Invus, Polaris Partners, Alexandria Venture Investments, and other investors. Triveni Bio's lead antibody program (TRIV-509) targets kallikreins 5 and 7 (KLK5/7), promising targets for the treatment of atopic dermatitis, asthma, and other I&I indications. "TRIV-509 works via a unique mechanism that directly impacts barrier dysfunction, inflammation, and itch. Novel therapeutic approaches for I&I diseases are much needed, especially for atopic dermatitis patients who generally have an inadequate response to Th2-targeted therapies," said Jennifer Dovey, Ph.D., Chief Scientific Officer of Triveni Bio. The financing will support the advancement of TRIV-509 from preclinical development to a Phase 2a clinical trial and fuel a pipeline of novel antibodies with two additional development candidate nominations expected in 2024. "We are grateful for the support of our investors who understand the upfront benefit of leveraging human genetics – especially learnings from rare Mendelian forms of disease – to expose novel drug targets relevant across multiple common diseases with shared traits," said industry veteran Vishal Patel, Ph.D., who joined Triveni Bio as Chief Executive Officer. "Triveni Bio is at a key inflection point as we transition into a clinical stage company with a compelling therapeutic pipeline and talented team." Triveni Bio is the result of a merger between Amagma Therapeutics, which was founded by Tillman Gerngross, Ph.D. and Leonard Zon, M.D. with funding from Polaris; and Modify Therapeutics, which was founded and seeded by Atlas. "The teams saw an opportunity to bridge highly complementary talent, technologies, and approaches to create a data-driven precision medicine company," said Jean-François Formela, M.D., partner at Atlas Venture and Board Chair of Triveni Bio. "We are excited to co-lead this round alongside Atlas and other committed investors. We look forward to working with the Triveni team to bring novel and highly promising biological therapies to patients suffering from inflammatory disorders," said Raymond Kelleher, M.D., Ph.D., Managing Director at Cormorant. Triveni Bio's data platform leverages both public and private datasets to identify novel genetically validated disease nodes, predict and stratify patient subpopulations, and provide novel insights into disease mechanisms – achieved in part through a collaboration with Nashville Biosciences. About Triveni Bio Triveni Bio is a biotech company pioneering a genetics-informed precision medicine approach to develop functional antibodies for the treatment of I&I disorders. The company's approach establishes proof-of-concept at the earliest stages of drug development. Through a strong understanding of genetics and mechanistic biology, our pipeline is powered for indication expansion where we know we can have the most impact. To learn more, visit . SOURCE Triveni Bio